國立高雄大學圖資館 |

Language: English

Back

Immune metabolism in health and tumor

Li, Bin.

Immune metabolism in health and tumor

Record Type:	Electronic resources : Monograph/item
Title/Author:	Immune metabolism in health and tumoredited by Bin Li, Fan Pan.
other author:	Li, Bin.
Published:	Dordrecht :Springer Netherlands :2017.
Description:	v, 223 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Immune systemMetabolism.
Online resource:	http://dx.doi.org/10.1007/978-94-024-1170-6
ISBN:	9789402411706$q(electronic bk.)

Immune metabolism in health and tumor
Immune metabolism in health and tumor[electronic resource] /edited by Bin Li, Fan Pan. - Dordrecht :Springer Netherlands :2017. - v, 223 p. :ill., digital ;24 cm. - Advances in experimental medicine and biology,v.10110065-2598 ;. - Advances in experimental medicine and biology ;946..

Metabolism in Immune Cell Differentiation and Function -- Metabolic Regulation of T cell Immunity -- Transcriptional regulation of T cell metabolism reprograming -- Adipose tissue-resident regulatory T cells -- Immune cell metabolism in tumor microenvironment -- Regulation of Metabolism across Different Subsets of T Cells in Cancer -- Immunometabolism in Tumour Microenvironment.

This book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients. The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of these pathways can lead to immune disorders. In different contexts, such as a tumor microenvironment, immune-cell function and identity may be modified not only by cytokines and checkpoint molecules, but also by nutrient availability and other metabolic stimuli. Transcriptional reprogramming confers many of the changes in immune cell metabolism that are seen when a T-cell, for example, undergoes activation or functional adaptation to different environments. Lastly, immune cells can destructively or protectively participate in human metabolic homeostasis or disorders. This book summarizes immune-metabolism from a variety of different perspectives, including the ways in which metabolic cues, pathways, and requirements of immune cells change in conditions of homeostasis and activation. The exploration of the significance of metabolic checkpoints and other cues, particularly in the context of cancer and immune disorders, may form the foundation for the development of therapeutics.

ISBN: 9789402411706$q(electronic bk.)

Standard No.: 10.1007/978-94-024-1170-6doiSubjects--Topical Terms:

792519
Immune system
--Metabolism.

LC Class. No.: QR182

Dewey Class. No.: 571.96

Immune metabolism in health and tumor
LDR:03081nmm a2200325 a 4500 001 522052
003 DE-He213
005 20170905094020.0
006 m d
007 cr nn 008maaau
008 180521s2017 ne s 0 eng d
020 $a 9789402411706$q(electronic bk.)
020 $a 9789402411683$q(paper)
024 7 $a 10.1007/978-94-024-1170-6 $2 doi
035 $a 978-94-024-1170-6
040 $a GP $c GP
041 0 $a eng
050 4 $a QR182
072 7 $a MJCM $2 bicssc
072 7 $a MED044000 $2 bisacsh
082 0 4 $a 571.96 $2 23
090 $a QR182 $b .I33 2017
245 0 0 $a Immune metabolism in health and tumor $h [electronic resource] / $c edited by Bin Li, Fan Pan.
260 $a Dordrecht : $b Springer Netherlands : $b Imprint: Springer, $c 2017.
300 $a v, 223 p. : $b ill., digital ; $c 24 cm.
490 1 $a Advances in experimental medicine and biology, $x 0065-2598 ; $v v.1011
505 0 $a Metabolism in Immune Cell Differentiation and Function -- Metabolic Regulation of T cell Immunity -- Transcriptional regulation of T cell metabolism reprograming -- Adipose tissue-resident regulatory T cells -- Immune cell metabolism in tumor microenvironment -- Regulation of Metabolism across Different Subsets of T Cells in Cancer -- Immunometabolism in Tumour Microenvironment.
520 $a This book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients. The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of these pathways can lead to immune disorders. In different contexts, such as a tumor microenvironment, immune-cell function and identity may be modified not only by cytokines and checkpoint molecules, but also by nutrient availability and other metabolic stimuli. Transcriptional reprogramming confers many of the changes in immune cell metabolism that are seen when a T-cell, for example, undergoes activation or functional adaptation to different environments. Lastly, immune cells can destructively or protectively participate in human metabolic homeostasis or disorders. This book summarizes immune-metabolism from a variety of different perspectives, including the ways in which metabolic cues, pathways, and requirements of immune cells change in conditions of homeostasis and activation. The exploration of the significance of metabolic checkpoints and other cues, particularly in the context of cancer and immune disorders, may form the foundation for the development of therapeutics.
650 0 $a Immune system $x Metabolism. $3 792519
650 0 $a Tumors $x Metabolism. $3 792520
650 0 $a T cells $x Metabolism. $3 792521
650 0 $a Leucocytes $x Immunology. $3 792522
650 1 4 $a Biomedicine. $3 273648
650 2 4 $a Immunology. $3 189152
650 2 4 $a Posttranslational Modification. $3 376429
650 2 4 $a Medical Microbiology. $3 273931
650 2 4 $a Cancer Research. $3 273660
700 1 $a Li, Bin. $3 296052
700 1 $a Pan, Fan. $3 792518
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer eBooks
830 0 $a Advances in experimental medicine and biology ; $v 946. $3 557559
856 4 0 $u http://dx.doi.org/10.1007/978-94-024-1170-6
950 $a Biomedical and Life Sciences (Springer-11642)