國立高雄大學圖資館 |

Language: English

Back

Chemical mixtures and combined chemi...

Rider, Cynthia V.

Chemical mixtures and combined chemical and nonchemical stressorsexposure, toxicity, analysis, and risk /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Chemical mixtures and combined chemical and nonchemical stressorsedited by Cynthia V. Rider, Jane Ellen Simmons.
Reminder of title:	exposure, toxicity, analysis, and risk /
other author:	Rider, Cynthia V.
Published:	Cham :Springer International Publishing :2018.
Description:	xiv, 556 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Toxicology.
Online resource:	http://dx.doi.org/10.1007/978-3-319-56234-6
ISBN:	9783319562346$q(electronic bk.)

Chemical mixtures and combined chemical and nonchemical stressorsexposure, toxicity, analysis, and risk /
Chemical mixtures and combined chemical and nonchemical stressorsexposure, toxicity, analysis, and risk /[electronic resource] :edited by Cynthia V. Rider, Jane Ellen Simmons. - Cham :Springer International Publishing :2018. - xiv, 556 p. :ill. (some col.), digital ;24 cm.

Introduction -- Combined exposures -- Measuring combined exposures -- Modeling complex exposures -- Prioritizing mixtures for study -- Environment-Wide Association Studies -- Biogeographical analysis of chemical co-occurrence -- Combining exposure and toxicity information to develop logical groupings for assessment -- Maximum Cumulative Ratio for deciding when to assess mixtures -- Establishing the "no interaction" baseline -- Dose addition models -- Response addition -- Integrated addition -- Mixture statistics - comparing predicted to observed -- Cumulative Risk Assessment -- Deciding which approach to use -- Component-based approaches -- Sufficient similarity of whole mixtures -- Other whole mixtures approaches -- Assessing interactions -- Likelihood and examples of chemical interactions -- PBPK modeling of chemical interactions -- Adding interactions to cumulative risk assessment -- Consideration of nonchemical stressors -- Toxicity and interactions of physical and chemical stressors -- Psychosocial and chemical stressors -- Adding nonchemical stressors to cumulative risk assessments -- Disease-based risk assessment -- Community-based risk assessment.

Exposure to multiple chemical and nonchemical stressors is the rule, not the exception. Nevertheless, it continues to be a significant challenge in toxicology and risk assessment to thoroughly take mixtures into account. In this book, both basic and advanced concepts for considering mixtures are discussed, from initial-exposure characterization through the evaluation of risk associated with combined exposures. Several chapters also examine the adoption of promising tools from other disciplines. Looking beyond chemical mixtures, the discussion also addresses incorporating nonchemical stressors into toxicity studies and cumulative-risk assessments. This "excellent" volume-as described by Linda S. Birnbaum, Director of the National Institute of Environmental Health Sciences and the National Toxicology Program, in her foreword to the book-forms "a comprehensive picture of the current state of mixtures science." With contributions from a host of established experts, Chemical Mixtures and Combined Chemical and Nonchemical Stressors: Exposure, Toxicity, Analysis, and Risk is an essential text for mixtures researchers in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics. Both seasoned mixtures researchers and those new to the field will appreciate the clear explanations of mixtures concepts as well as the comprehensive presentation of available tools for predicting mixture effects and estimating risk from combined exposures. This volume also serves as a useful reference book for students.

ISBN: 9783319562346$q(electronic bk.)

Standard No.: 10.1007/978-3-319-56234-6doiSubjects--Topical Terms:

206218
Toxicology.

LC Class. No.: RA1211

Dewey Class. No.: 615.9

Chemical mixtures and combined chemical and nonchemical stressorsexposure, toxicity, analysis, and risk /
LDR:03746nmm a2200313 a 4500 001 531593
003 DE-He213
005 20180821155950.0
006 m d
007 cr nn 008maaau
008 181113s2018 gw s 0 eng d
020 $a 9783319562346$q(electronic bk.)
020 $a 9783319562322$q(paper)
024 7 $a 10.1007/978-3-319-56234-6 $2 doi
035 $a 978-3-319-56234-6
040 $a GP $c GP
041 0 $a eng
050 4 $a RA1211
072 7 $a MMG $2 bicssc
072 7 $a MED071000 $2 bisacsh
082 0 4 $a 615.9 $2 23
090 $a RA1211 $b .C517 2018
245 0 0 $a Chemical mixtures and combined chemical and nonchemical stressors $h [electronic resource] : $b exposure, toxicity, analysis, and risk / $c edited by Cynthia V. Rider, Jane Ellen Simmons.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2018.
300 $a xiv, 556 p. : $b ill. (some col.), digital ; $c 24 cm.
505 0 $a Introduction -- Combined exposures -- Measuring combined exposures -- Modeling complex exposures -- Prioritizing mixtures for study -- Environment-Wide Association Studies -- Biogeographical analysis of chemical co-occurrence -- Combining exposure and toxicity information to develop logical groupings for assessment -- Maximum Cumulative Ratio for deciding when to assess mixtures -- Establishing the "no interaction" baseline -- Dose addition models -- Response addition -- Integrated addition -- Mixture statistics - comparing predicted to observed -- Cumulative Risk Assessment -- Deciding which approach to use -- Component-based approaches -- Sufficient similarity of whole mixtures -- Other whole mixtures approaches -- Assessing interactions -- Likelihood and examples of chemical interactions -- PBPK modeling of chemical interactions -- Adding interactions to cumulative risk assessment -- Consideration of nonchemical stressors -- Toxicity and interactions of physical and chemical stressors -- Psychosocial and chemical stressors -- Adding nonchemical stressors to cumulative risk assessments -- Disease-based risk assessment -- Community-based risk assessment.
520 $a Exposure to multiple chemical and nonchemical stressors is the rule, not the exception. Nevertheless, it continues to be a significant challenge in toxicology and risk assessment to thoroughly take mixtures into account. In this book, both basic and advanced concepts for considering mixtures are discussed, from initial-exposure characterization through the evaluation of risk associated with combined exposures. Several chapters also examine the adoption of promising tools from other disciplines. Looking beyond chemical mixtures, the discussion also addresses incorporating nonchemical stressors into toxicity studies and cumulative-risk assessments. This "excellent" volume-as described by Linda S. Birnbaum, Director of the National Institute of Environmental Health Sciences and the National Toxicology Program, in her foreword to the book-forms "a comprehensive picture of the current state of mixtures science." With contributions from a host of established experts, Chemical Mixtures and Combined Chemical and Nonchemical Stressors: Exposure, Toxicity, Analysis, and Risk is an essential text for mixtures researchers in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics. Both seasoned mixtures researchers and those new to the field will appreciate the clear explanations of mixtures concepts as well as the comprehensive presentation of available tools for predicting mixture effects and estimating risk from combined exposures. This volume also serves as a useful reference book for students.
650 0 $a Toxicology. $3 206218
650 0 $a Chemicals. $3 265745
650 1 4 $a Biomedicine. $3 273648
650 2 4 $a Pharmacology/Toxicology. $3 273652
650 2 4 $a Epidemiology. $3 191577
650 2 4 $a Environmental Health. $3 245780
700 1 $a Rider, Cynthia V. $3 806139
700 1 $a Simmons, Jane Ellen. $3 806140
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-56234-6
950 $a Biomedical and Life Sciences (Springer-11642)