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Precision molecular pathology of pro...

Robinson, Brian D.

Precision molecular pathology of prostate cancer

Record Type:	Electronic resources : Monograph/item
Title/Author:	Precision molecular pathology of prostate canceredited by Brian D. Robinson ... [et al.].
other author:	Robinson, Brian D.
Published:	Cham :Springer International Publishing :2018.
Description:	xiv, 570 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	ProstateCancer
Online resource:	http://dx.doi.org/10.1007/978-3-319-64096-9
ISBN:	9783319640969$q(electronic bk.)

Precision molecular pathology of prostate cancer
Precision molecular pathology of prostate cancer[electronic resource] /edited by Brian D. Robinson ... [et al.]. - Cham :Springer International Publishing :2018. - xiv, 570 p. :ill., digital ;24 cm. - Molecular pathology library,1935-987X. - Molecular pathology library..

Part I. General principles -- Approach to patient -- Etiology -- Precursor and pre-invasive lesions of prostate cancer -- Prostatic adenocarcinoma: morphologic spectrum, Gleason scoring, etc -- Genetic susceptibility -- DNA damage repair, BRCA mutations, DNA adducts, SNPs -- Racial differences -- Cancer stem cells Part II. Molecular signatures of primary prostate cancer -- SNPs -- Copy number variation/chromosomal aberration (PTEN deletion, etc.) -- Gene fusions (TMPRSS2:ERG, etc.) -- Gene expression arrays -- Next generation sequencing (point mutations, indels, etc.) -- Epigenetic changes (chromatin remodeling, etc.) -- Proteomics -- Metabolomics -- miRNA and lncRNA Part III. Molecular signatures of advanced prostate cancer -- Lymph node metastasis -- Bone metastasis a -- RANKL, Src kinases, endothelins, bisphosphonates -- Visceral metastasis a -- Role of extracellular matrix, angiogenesis, epithelial-mesenchymal transition (EMT), inflammation -- Castration resistant prostate cancer (CRPC) -- Neuroendocrine prostate cancer (NEPC) Part IV. Key molecular pathways in prostate cancer development and progression -- Androgen receptor in carcinogenesis -- Androgen receptor in progression (CRPC) -- PI3K/Akt/mTOR/PTEN and ERK/MAPK pathways -- Cell cycle regulators (p53, etc.) -- DNA damage repair -- Tyrosine kinase signaling (EGFR, VEGFR, PDGFR, FGFR, IGFR, etc.) -- Cytoskeletal function (microtubules and taxane therapy) Part V. Precision medicine approach: Diagnosis, treatment, prognosis -- Molecular diagnosis -- Molecular imaging -- Molecular prognostic markers/tests -- Molecular targeted therapies -- Towards molecular classification of prostate cancer.

ISBN: 9783319640969$q(electronic bk.)

Standard No.: 10.1007/978-3-319-64096-9doiSubjects--Topical Terms:

806809
Prostate
--Cancer

LC Class. No.: RC280.P7

Dewey Class. No.: 616.994630758

Precision molecular pathology of prostate cancer
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