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Resistance to anti-cancer therapeuti...

Elkabets, Moshe.

Resistance to anti-cancer therapeutics targeting receptor tyrosine kinases and downstream pathways

Record Type:	Electronic resources : Monograph/item
Title/Author:	Resistance to anti-cancer therapeutics targeting receptor tyrosine kinases and downstream pathwaysedited by Yosef Yarden, Moshe Elkabets.
other author:	Yarden, Yosef.
Published:	Cham :Springer International Publishing :2018.
Description:	xx, 242 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Drug resistance in cancer cells.
Online resource:	http://dx.doi.org/10.1007/978-3-319-67932-7
ISBN:	9783319679327$q(electronic bk.)

Resistance to anti-cancer therapeutics targeting receptor tyrosine kinases and downstream pathways
Resistance to anti-cancer therapeutics targeting receptor tyrosine kinases and downstream pathways[electronic resource] /edited by Yosef Yarden, Moshe Elkabets. - Cham :Springer International Publishing :2018. - xx, 242 p. :ill., digital ;24 cm. - Resistance to targeted anti-cancer therapeutics,v.152196-5501 ;. - Resistance to targeted anti-cancer therapeutics ;v.4..

Resistance of colorectal tumors to anti-EGFR antibodies -- Resistance of lung cancer to kinase inhibitors specific to EGFR or ALK -- Mechanisms of action and resistance of trastuzumab in breast cancer -- Mechanisms of resistance to molecular therapies targeting the HGF/MET axis -- RAF, MEK and ERK inhibitors as anti-cancer drugs: intrinsic and acquired resistance as a major therapeutic challenge -- Mechanisms of resistance to PI3K and AKT inhibitors -- Sensitivity and resistance to BH3 mimetics in cancer therapy -- Resistance mechanisms to cyclin-dependent kinase inhibitors -- Resistance to inhibitors of angiogenesis.

This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression. Each chapter will cover a specific group of targets and the cognate drugs, along with molecular modes of innate and evolving resistance.

ISBN: 9783319679327$q(electronic bk.)

Standard No.: 10.1007/978-3-319-67932-7doiSubjects--Topical Terms:

281104
Drug resistance in cancer cells.

LC Class. No.: RC271.C5 / R475 2018

Dewey Class. No.: 616.994061

Resistance to anti-cancer therapeutics targeting receptor tyrosine kinases and downstream pathways
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490 1 $a Resistance to targeted anti-cancer therapeutics, $x 2196-5501 ; $v v.15
505 0 $a Resistance of colorectal tumors to anti-EGFR antibodies -- Resistance of lung cancer to kinase inhibitors specific to EGFR or ALK -- Mechanisms of action and resistance of trastuzumab in breast cancer -- Mechanisms of resistance to molecular therapies targeting the HGF/MET axis -- RAF, MEK and ERK inhibitors as anti-cancer drugs: intrinsic and acquired resistance as a major therapeutic challenge -- Mechanisms of resistance to PI3K and AKT inhibitors -- Sensitivity and resistance to BH3 mimetics in cancer therapy -- Resistance mechanisms to cyclin-dependent kinase inhibitors -- Resistance to inhibitors of angiogenesis.
520 $a This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression. Each chapter will cover a specific group of targets and the cognate drugs, along with molecular modes of innate and evolving resistance.
650 0 $a Drug resistance in cancer cells. $3 281104
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650 1 4 $a Biomedicine. $3 273648
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700 1 $a Yarden, Yosef. $3 711677
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