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Analytical characterization of bioth...

Lill, Jennie R.

Analytical characterization of biotherapeutics

Record Type:	Electronic resources : Monograph/item
Title/Author:	Analytical characterization of biotherapeuticsedited by Jennie R. Lill and Wendy Sandoval.
other author:	Lill, Jennie R.
Published:	Hoboken, NJ :John Wiley & Sons,2017.
Description:	1 online resource.
Subject:	ProteinsTherapeutic use.
Online resource:	https://onlinelibrary.wiley.com/doi/book/10.1002/9781119384434
ISBN:	9781119384434$q(electronic bk.)

Analytical characterization of biotherapeutics
Analytical characterization of biotherapeutics[electronic resource] /edited by Jennie R. Lill and Wendy Sandoval. - 1st ed. - Hoboken, NJ :John Wiley & Sons,2017. - 1 online resource.

Includes bibliographical references and index.

"The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics research Analytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions. In addition, it frames critical questions warranting attention in the design and delivery of a therapeutic protein, exposes analytical challenges that may occur when characterizing these molecules, and presents a number of tested solutions. The first single-volume guide of its kind, Analytical Characterization of Biotherapeutics brings together contributions from scientists at the leading edge of biotherapeutics research and manufacturing. Key topics covered in-depth include the structural characterization of recombinant proteins and antibodies, antibody de novo sequencing, characterization of antibody drug conjugates, characterization of bi-specific or other hybrid molecules, characterization of manufacturing host-cell contaminant proteins, analytical tools for biologics molecular assessment, and more. Each chapter is written by a recognized expert or experts in their field who discuss current and cutting edge approaches to fully characterizing biotherapeutic proteins and antigen reagents Covers the full range of characterization strategies for large molecule based therapeutics Provides an up-to-date account of the latest approaches used for large molecule characterization Chapters cover the background needed to understand the challenges at hand, solutions to characterize these large molecules, and a summary of emerging options for analytical characterization, Analytical Characterization of Biotherapeutics is an up-to-date resource for analytical scientists, biologists, and mass spectrometrists involved in the analysis of biomolecules, as well as scientists employed in the pharmaceuticals and biotechnology industries. Graduate students in biology and analytical science, and their instructors will find it to be fascinating and instructive supplementary reading.--Provided by publisher

ISBN: 9781119384434$q(electronic bk.)

LCCN: 2017022128Subjects--Topical Terms:

225255
Proteins
--Therapeutic use.

LC Class. No.: RM666.P87

Dewey Class. No.: 615.7

National Library of Medicine Call No.: QU 55

Analytical characterization of biotherapeutics
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010 $a 2017022128
020 $a 9781119384434$q(electronic bk.)
020 $a 1119384435$q(electronic bk.)
020 $a 9781119384427$q(pdf)
020 $a 1119384427$q(pdf)
020 $a 9781119384403$q(epub)
020 $a 1119384400$q(epub)
020 $z 9781119053101$q(hardback)
035 $a 986523803
040 $a DLC $b eng $c DLC $d OCLCF $d N $d DG1 $d IDEBK $d EBLCP $d OCLCO $d OCLCQ $d TXM $d UAB $d UPM $d YDX $d OCLCO $d OCLCQ $d MERER $d OCLCO $d OCLCA $d DEBSZ $d OCLCQ
050 0 0 $a RM666.P87
060 4 $a QU 55
082 0 0 $a 615.7 $2 23
245 0 0 $a Analytical characterization of biotherapeutics $h [electronic resource] / $c edited by Jennie R. Lill and Wendy Sandoval.
250 $a 1st ed.
260 $a Hoboken, NJ : $b John Wiley & Sons, $c 2017.
300 $a 1 online resource.
504 $a Includes bibliographical references and index.
520 $a "The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics research Analytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions. In addition, it frames critical questions warranting attention in the design and delivery of a therapeutic protein, exposes analytical challenges that may occur when characterizing these molecules, and presents a number of tested solutions. The first single-volume guide of its kind, Analytical Characterization of Biotherapeutics brings together contributions from scientists at the leading edge of biotherapeutics research and manufacturing. Key topics covered in-depth include the structural characterization of recombinant proteins and antibodies, antibody de novo sequencing, characterization of antibody drug conjugates, characterization of bi-specific or other hybrid molecules, characterization of manufacturing host-cell contaminant proteins, analytical tools for biologics molecular assessment, and more. Each chapter is written by a recognized expert or experts in their field who discuss current and cutting edge approaches to fully characterizing biotherapeutic proteins and antigen reagents Covers the full range of characterization strategies for large molecule based therapeutics Provides an up-to-date account of the latest approaches used for large molecule characterization Chapters cover the background needed to understand the challenges at hand, solutions to characterize these large molecules, and a summary of emerging options for analytical characterization, Analytical Characterization of Biotherapeutics is an up-to-date resource for analytical scientists, biologists, and mass spectrometrists involved in the analysis of biomolecules, as well as scientists employed in the pharmaceuticals and biotechnology industries. Graduate students in biology and analytical science, and their instructors will find it to be fascinating and instructive supplementary reading.--Provided by publisher
520 $a "This book covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions"--Provided by publisher.
588 $a Description based on print version record.
650 0 $a Proteins $x Therapeutic use. $3 225255
650 0 $a Proteins $x Analysis. $3 194675
650 1 2 $a Recombinant Proteins $x analysis. $3 813109
650 1 2 $a Recombinant Proteins $x therapeutic use. $3 302682
650 2 2 $a Antibodies $x analysis. $3 813110
650 2 2 $a Antibodies $x therapeutic use. $3 372454
650 2 2 $a Biological Therapy $x methods. $3 520523
700 1 $a Lill, Jennie R. $3 813107
700 1 $a Sandoval, Wendy N. $3 813108
856 4 0 $u https://onlinelibrary.wiley.com/doi/book/10.1002/9781119384434