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Targeting trafficking in drug development

Record Type:	Electronic resources : Monograph/item
Title/Author:	Targeting trafficking in drug developmentedited by Alfredo Ulloa-Aguirre, Ya-Xiong Tao.
other author:	Ulloa-Aguirre, Alfredo.
Published:	Cham :Springer International Publishing :2018.
Description:	viii, 425 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Molecular pharmacology.
Online resource:	http://dx.doi.org/10.1007/978-3-319-74164-2
ISBN:	9783319741642$q(electronic bk.)

Targeting trafficking in drug development
Targeting trafficking in drug development[electronic resource] /edited by Alfredo Ulloa-Aguirre, Ya-Xiong Tao. - Cham :Springer International Publishing :2018. - viii, 425 p. :ill., digital ;24 cm. - Handbook of experimental pharmacology,v.2450171-2004 ;. - Handbook of experimental pharmacology ;208..

1. Intracellular trafficking of gonadotropin receptors in health and disease -- 2. Investigating internalization and intracellular trafficking of GPCRs -- 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors -- 4. Targeting of disordered proteins by small molecules in neurodegenerative diseases -- 5. Pharmacoperones for misfolded gonadotropin receptors -- 6. Pharmacological chaperones: Beyond conformational disorders -- 7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer -- 8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches -- 9. Conserved oligomeric Golgi and neuronal vesicular trafficking -- 10. SLC6 transporter folding diseases and pharmacochaperoning -- 11. The molecular physiopathogenesis of islet amyloidosis -- 12. Folding defects leading to primary hyperoxaluria -- 13. Potential pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria.

Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.

ISBN: 9783319741642$q(electronic bk.)

Standard No.: 10.1007/978-3-319-74164-2doiSubjects--Topical Terms:

206041
Molecular pharmacology.

LC Class. No.: RM301.65 / .T374 2018

Dewey Class. No.: 615.1

Targeting trafficking in drug development
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505 0 $a 1. Intracellular trafficking of gonadotropin receptors in health and disease -- 2. Investigating internalization and intracellular trafficking of GPCRs -- 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors -- 4. Targeting of disordered proteins by small molecules in neurodegenerative diseases -- 5. Pharmacoperones for misfolded gonadotropin receptors -- 6. Pharmacological chaperones: Beyond conformational disorders -- 7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer -- 8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches -- 9. Conserved oligomeric Golgi and neuronal vesicular trafficking -- 10. SLC6 transporter folding diseases and pharmacochaperoning -- 11. The molecular physiopathogenesis of islet amyloidosis -- 12. Folding defects leading to primary hyperoxaluria -- 13. Potential pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria.
520 $a Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.
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650 0 $a Drug targeting. $3 194481
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