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A new kind of computational biologyc...

Chaudhuri, Parimal Pal.

A new kind of computational biologycellular automata based models for genomics and proteomics /

Record Type:	Electronic resources : Monograph/item
Title/Author:	A new kind of computational biologyby Parimal Pal Chaudhuri ... [et al.].
Reminder of title:	cellular automata based models for genomics and proteomics /
other author:	Chaudhuri, Parimal Pal.
Published:	Singapore :Springer Singapore :2018.
Description:	xx, 335 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Cellular automata.
Online resource:	https://doi.org/10.1007/978-981-13-1639-5
ISBN:	9789811316395$q(electronic bk.)

A new kind of computational biologycellular automata based models for genomics and proteomics /
A new kind of computational biologycellular automata based models for genomics and proteomics /[electronic resource] :by Parimal Pal Chaudhuri ... [et al.]. - Singapore :Springer Singapore :2018. - xx, 335 p. :ill. (some col.), digital ;24 cm.

Chapter 1. Introduction to Biological Strings and Cellular Automata Preliminaries -- Chapter 2. Cellular Automata Modelling for Biological Strings -- Chapter 3. Codon String of mRNA Modelled with Cellular Automata -- Chapter 4. Developing the Cellular Automata Model for a Peptide Chain of Amino Acids -- Chapter 5. In-silico Protein Structure Synthesis and its Relevance in Biological Functions -- Chapter 6. Analysis of DNA String with Cellular Automata Framework.

This book reflects more than three decades of research on Cellular Automata (CA), and nearly a decade of work on the application of CA to model biological strings, which forms the foundation of 'A New Kind of Computational Biology' pioneered by the start-up, CARLBio. After a brief introduction on Cellular Automata (CA) theory and functional biology, it reports on the modeling of basic biological strings with CA, starting with the basic nucleotides leading to codon and anti-codon CA models. It derives a more involved CA model of DNA, RNA, the entire translation process for amino acid formation and the evolution of protein to its unique structure and function. In subsequent chapters the interaction of Proteins with other bio-molecules is also modeled. The only prior knowledge assumed necessary is an undergraduate knowledge of computer programming and biology. The book adopts a hands-on, "do-it-yourself" approach to enable readers to apply the method provided to derive the CA rules and comprehend how these are related to the physical 'rules' observed in biology. In a single framework, the authors have presented two branches of science - Computation and Biology. Instead of rigorous molecular dynamics modeling, which the authors describe as a Bottoms-Up model, or relying on the Top-Down new age Artificial Intelligence (AI) and Machine Language (ML) that depends on extensive availability of quality data, this book takes the best from both the Top-Down and Bottoms-up approaches and establishes how the behavior of complex molecules is represented in CA. The CA rules are derived from the basic knowledge of molecular interaction and construction observed in biological world but mapped to a few subset of known results to derive and predict results. This book is useful for students, researchers and industry practitioners who want to explore modeling and simulation of the physical world complex systems from a different perspective. It raises the inevitable the question - 'Are life and the universe nothing but a collection of continuous systems processing information'.

ISBN: 9789811316395$q(electronic bk.)

Standard No.: 10.1007/978-981-13-1639-5doiSubjects--Topical Terms:

211503
Cellular automata.

LC Class. No.: QA267.5.C45

Dewey Class. No.: 006.3822

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245 0 2 $a A new kind of computational biology $h [electronic resource] : $b cellular automata based models for genomics and proteomics / $c by Parimal Pal Chaudhuri ... [et al.].
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505 0 $a Chapter 1. Introduction to Biological Strings and Cellular Automata Preliminaries -- Chapter 2. Cellular Automata Modelling for Biological Strings -- Chapter 3. Codon String of mRNA Modelled with Cellular Automata -- Chapter 4. Developing the Cellular Automata Model for a Peptide Chain of Amino Acids -- Chapter 5. In-silico Protein Structure Synthesis and its Relevance in Biological Functions -- Chapter 6. Analysis of DNA String with Cellular Automata Framework.
520 $a This book reflects more than three decades of research on Cellular Automata (CA), and nearly a decade of work on the application of CA to model biological strings, which forms the foundation of 'A New Kind of Computational Biology' pioneered by the start-up, CARLBio. After a brief introduction on Cellular Automata (CA) theory and functional biology, it reports on the modeling of basic biological strings with CA, starting with the basic nucleotides leading to codon and anti-codon CA models. It derives a more involved CA model of DNA, RNA, the entire translation process for amino acid formation and the evolution of protein to its unique structure and function. In subsequent chapters the interaction of Proteins with other bio-molecules is also modeled. The only prior knowledge assumed necessary is an undergraduate knowledge of computer programming and biology. The book adopts a hands-on, "do-it-yourself" approach to enable readers to apply the method provided to derive the CA rules and comprehend how these are related to the physical 'rules' observed in biology. In a single framework, the authors have presented two branches of science - Computation and Biology. Instead of rigorous molecular dynamics modeling, which the authors describe as a Bottoms-Up model, or relying on the Top-Down new age Artificial Intelligence (AI) and Machine Language (ML) that depends on extensive availability of quality data, this book takes the best from both the Top-Down and Bottoms-up approaches and establishes how the behavior of complex molecules is represented in CA. The CA rules are derived from the basic knowledge of molecular interaction and construction observed in biological world but mapped to a few subset of known results to derive and predict results. This book is useful for students, researchers and industry practitioners who want to explore modeling and simulation of the physical world complex systems from a different perspective. It raises the inevitable the question - 'Are life and the universe nothing but a collection of continuous systems processing information'.
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650 2 4 $a Microbial Genetics and Genomics. $3 273651
650 2 4 $a Proteomics. $3 220403
700 1 $a Chaudhuri, Parimal Pal. $3 823052
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