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Development of antibody-based therap...

Bornstein, Gadi G.

Development of antibody-based therapeuticstranslational considerations & challenges /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Development of antibody-based therapeuticsedited by Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp.
Reminder of title:	translational considerations & challenges /
other author:	Tabrizi, Mohammad A.
Published:	Singapore :Springer Singapore :2018.
Description:	viii, 248 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Monoclonal antibodiesTherapeutic use.
Online resource:	https://doi.org/10.1007/978-981-13-0496-5
ISBN:	9789811304965$q(electronic bk.)

Development of antibody-based therapeuticstranslational considerations & challenges /
Development of antibody-based therapeuticstranslational considerations & challenges /[electronic resource] :edited by Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp. - 2nd ed. - Singapore :Springer Singapore :2018. - viii, 248 p. :ill., digital ;24 cm.

1. Introduction -- 2. Translational Considerations and Challenges: An Overview -- 3. Considerations for Construct and Affinity Design Goals -- 4. Epitope Characterization and Isotype Selection -- 5. Biophysical Considerations for Development of Antibody-Based Therapeutics -- 6. Novel Technologies for Generation of Bispecific Constructs -- 7. Stimulus-Response Mechanisms: An Overview -- 8. Evaluation of Tumor Growth Inhibition in Preclinical Tumor Models -A Quantitative Approach -- 9. Application of Proof-of-Mechanism Biomarkers (POM) in Design and Development of Biologics Modalities -- 10. Antibody Drug Conjugates: Translational Considerations -- 11. Application of PK-PD Modeling and Simulation Approaches for Immuno-Oncology Drugs -- 12. Translational Biomarkers: Application in the Clinical Development of Combination Therapies.

ISBN: 9789811304965$q(electronic bk.)

Standard No.: 10.1007/978-981-13-0496-5doiSubjects--Topical Terms:

194071
Monoclonal antibodies
--Therapeutic use.

LC Class. No.: RM282.M65 / D484 2018

Dewey Class. No.: 615.37

Development of antibody-based therapeuticstranslational considerations & challenges /
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245 0 0 $a Development of antibody-based therapeutics $h [electronic resource] : $b translational considerations & challenges / $c edited by Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp.
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300 $a viii, 248 p. : $b ill., digital ; $c 24 cm.
505 0 $a 1. Introduction -- 2. Translational Considerations and Challenges: An Overview -- 3. Considerations for Construct and Affinity Design Goals -- 4. Epitope Characterization and Isotype Selection -- 5. Biophysical Considerations for Development of Antibody-Based Therapeutics -- 6. Novel Technologies for Generation of Bispecific Constructs -- 7. Stimulus-Response Mechanisms: An Overview -- 8. Evaluation of Tumor Growth Inhibition in Preclinical Tumor Models -A Quantitative Approach -- 9. Application of Proof-of-Mechanism Biomarkers (POM) in Design and Development of Biologics Modalities -- 10. Antibody Drug Conjugates: Translational Considerations -- 11. Application of PK-PD Modeling and Simulation Approaches for Immuno-Oncology Drugs -- 12. Translational Biomarkers: Application in the Clinical Development of Combination Therapies.
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650 2 4 $a Pharmacology/Toxicology. $3 273652
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700 1 $a Tabrizi, Mohammad A. $3 561880
700 1 $a Bornstein, Gadi G. $3 561881
700 1 $a Klakamp, Scott L. $3 561882
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