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Targeting Notch in cancerfrom the fr...

Artavanis-Tsakonas, Spyros.

Targeting Notch in cancerfrom the fruit fly to the Clinic /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Targeting Notch in canceredited by Lucio Miele, Spyros Artavanis-Tsakonas.
其他題名:	from the fruit fly to the Clinic /
其他作者:	Miele, Lucio.
出版者:	New York, NY :Springer New York :2018.
面頁冊數:	viii, 389 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
標題:	Cancer.
電子資源:	https://doi.org/10.1007/978-1-4939-8859-4
ISBN:	9781493988594$q(electronic bk.)

Targeting Notch in cancerfrom the fruit fly to the Clinic /
Targeting Notch in cancerfrom the fruit fly to the Clinic /[electronic resource] :edited by Lucio Miele, Spyros Artavanis-Tsakonas. - New York, NY :Springer New York :2018. - viii, 389 p. :ill., digital ;24 cm.

Structural Biology of Notch Signaling -- Non-Canonical Notch Signaling -- Dual Function of Notch Signaling in Cancer - Oncogene and Tumorsuppressor -- Out on the Fringe: Modulation of Notch Signaling by Glycosylation -- Notch signaling: A pivot regulator of adaptive and innate immunity -- Notch in Ovarian Cancer -- Notch Signaling in Graft-versus-Host Disease -- Notch Signaling in T-Cell Acute Lymphoblastic Leukemia and Other Hematologic Malignancies -- The Role of Notch in Breast Cancer -- Notch in Lung Cancer -- Notch Signaling in Pediatric Soft tissue Sarcoma -- Notch Ligands in Hematopoietic Stem Cell production -- Notch Signaling in the normal intestine and intestinal Cancer -- Notch Signaling in Estrogen-Dependent Cancers -- Index.

The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets. Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected.

ISBN: 9781493988594$q(electronic bk.)

Standard No.: 10.1007/978-1-4939-8859-4doiSubjects--Topical Terms:

195182
Cancer.

LC Class. No.: RC262 / .T374 2018

Dewey Class. No.: 616.994

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520 $a The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets. Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected.
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