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The unfolded protein response in cancer

Clarke, Robert.

The unfolded protein response in cancer

Record Type:	Electronic resources : Monograph/item
Title/Author:	The unfolded protein response in canceredited by Robert Clarke.
other author:	Clarke, Robert.
Published:	Cham :Springer International Publishing :2019.
Description:	xi, 220 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
Subject:	CancerMolecular aspects.
Online resource:	https://doi.org/10.1007/978-3-030-05067-2
ISBN:	9783030050672$q(electronic bk.)

The unfolded protein response in cancer
The unfolded protein response in cancer[electronic resource] /edited by Robert Clarke. - Cham :Springer International Publishing :2019. - xi, 220 p. :ill. (some col.), digital ;24 cm. - Cancer drug discovery and development,2196-9906. - Cancer drug discovery and development..

Introduction: The Unfolded Protein Response -- Endoplasmic Reticulum Stress Signaling During Development -- Regulation of the Unfolded Protein Response and its Roles in Tumorigenesis and Cancer Therapy -- ATF4, Hypoxia and Treatment Resistance in Cancer -- Role of Protein Translation in the Unfolded Protein Response -- Roles of Spliced and Unspliced XBP1 in Breast Cancer -- The Unfolded Protein Response in Triple-Negative Breast Cancer -- The Unfolded Protein Response as an Integrator of Response to Endocrine Therapy in Estrogen Receptor Positive Breast Cancer -- Outside the Endoplasmic Reticulum: Non-Canonical GRP78 Signaling -- Autophagy and the Unfolded Protein Response in Neurodegenerative Diseases -- Index.

This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.

ISBN: 9783030050672$q(electronic bk.)

Standard No.: 10.1007/978-3-030-05067-2doiSubjects--Topical Terms:

221221
Cancer
--Molecular aspects.

LC Class. No.: RC268.4

Dewey Class. No.: 616.99407

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260 $a Cham : $b Springer International Publishing : $b Imprint: Humana Press, $c 2019.
300 $a xi, 220 p. : $b ill. (some col.), digital ; $c 24 cm.
490 1 $a Cancer drug discovery and development, $x 2196-9906
505 0 $a Introduction: The Unfolded Protein Response -- Endoplasmic Reticulum Stress Signaling During Development -- Regulation of the Unfolded Protein Response and its Roles in Tumorigenesis and Cancer Therapy -- ATF4, Hypoxia and Treatment Resistance in Cancer -- Role of Protein Translation in the Unfolded Protein Response -- Roles of Spliced and Unspliced XBP1 in Breast Cancer -- The Unfolded Protein Response in Triple-Negative Breast Cancer -- The Unfolded Protein Response as an Integrator of Response to Endocrine Therapy in Estrogen Receptor Positive Breast Cancer -- Outside the Endoplasmic Reticulum: Non-Canonical GRP78 Signaling -- Autophagy and the Unfolded Protein Response in Neurodegenerative Diseases -- Index.
520 $a This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.
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