國立高雄大學圖資館 |

Language: English

Back

Structural bioinformaticsapplication...

Mohan, C. Gopi.

Structural bioinformaticsapplications in preclinical drug discovery process /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Structural bioinformaticsedited by C. Gopi Mohan.
Reminder of title:	applications in preclinical drug discovery process /
other author:	Mohan, C. Gopi.
Published:	Cham :Springer International Publishing :2019.
Description:	xii, 406 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Drug development.
Online resource:	https://doi.org/10.1007/978-3-030-05282-9
ISBN:	9783030052829$q(electronic bk.)

Structural bioinformaticsapplications in preclinical drug discovery process /
Structural bioinformaticsapplications in preclinical drug discovery process /[electronic resource] :edited by C. Gopi Mohan. - Cham :Springer International Publishing :2019. - xii, 406 p. :ill. (some col.), digital ;24 cm. - Challenges and advances in computational chemistry and physics,v.272542-4491 ;. - Challenges and advances in computational chemistry and physics ;v.11.

Free Energy based methods to understand drug resistant mutations -- Structure-based inhibitor design for some multi-targeted drugs and its ADMET profile -- Structure-based drug design in anti-malarial agent identification -- Epigenome - the guide to genomic expression for different diseases -- Structure-based design towards Anti-Alzheimer agents -- Challenges of Structure-based drug design and discovery.

This book reviews the advances and challenges of structure-based drug design in the preclinical drug discovery process, addressing various diseases, including malaria, tuberculosis and cancer. Written by internationally recognized researchers, this edited book discusses how the application of the various in-silico techniques, such as molecular docking, virtual screening, pharmacophore modeling, molecular dynamics simulations, and residue interaction networks offers insights into pharmacologically active novel molecular entities. It presents a clear concept of the molecular mechanism of different drug targets and explores methods to help understand drug resistance. In addition, it includes chapters dedicated to natural-product- derived medicines, combinatorial drug discovery, the CryoEM technique for structure-based drug design and big data in drug discovery. The book offers an invaluable resource for graduate and postgraduate students, as well as for researchers in academic and industrial laboratories working in the areas of chemoinformatics, medicinal and pharmaceutical chemistry and pharmacoinformatics.

ISBN: 9783030052829$q(electronic bk.)

Standard No.: 10.1007/978-3-030-05282-9doiSubjects--Topical Terms:

190608
Drug development.

LC Class. No.: RM301.25 / .S778 2019

Dewey Class. No.: 615.19

Structural bioinformaticsapplications in preclinical drug discovery process /
LDR:02674nmm a2200349 a 4500 001 555141
003 DE-He213
005 20190624103852.0
006 m d
007 cr nn 008maaau
008 191121s2019 gw s 0 eng d
020 $a 9783030052829$q(electronic bk.)
020 $a 9783030052812$q(paper)
024 7 $a 10.1007/978-3-030-05282-9 $2 doi
035 $a 978-3-030-05282-9
040 $a GP $c GP
041 0 $a eng
050 4 $a RM301.25 $b .S778 2019
072 7 $a PN $2 bicssc
072 7 $a SCI013000 $2 bisacsh
072 7 $a PN $2 thema
072 7 $a UB $2 thema
082 0 4 $a 615.19 $2 23
090 $a RM301.25 $b .S927 2019
245 0 0 $a Structural bioinformatics $h [electronic resource] : $b applications in preclinical drug discovery process / $c edited by C. Gopi Mohan.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2019.
300 $a xii, 406 p. : $b ill. (some col.), digital ; $c 24 cm.
490 1 $a Challenges and advances in computational chemistry and physics, $x 2542-4491 ; $v v.27
505 0 $a Free Energy based methods to understand drug resistant mutations -- Structure-based inhibitor design for some multi-targeted drugs and its ADMET profile -- Structure-based drug design in anti-malarial agent identification -- Epigenome - the guide to genomic expression for different diseases -- Structure-based design towards Anti-Alzheimer agents -- Challenges of Structure-based drug design and discovery.
520 $a This book reviews the advances and challenges of structure-based drug design in the preclinical drug discovery process, addressing various diseases, including malaria, tuberculosis and cancer. Written by internationally recognized researchers, this edited book discusses how the application of the various in-silico techniques, such as molecular docking, virtual screening, pharmacophore modeling, molecular dynamics simulations, and residue interaction networks offers insights into pharmacologically active novel molecular entities. It presents a clear concept of the molecular mechanism of different drug targets and explores methods to help understand drug resistance. In addition, it includes chapters dedicated to natural-product- derived medicines, combinatorial drug discovery, the CryoEM technique for structure-based drug design and big data in drug discovery. The book offers an invaluable resource for graduate and postgraduate students, as well as for researchers in academic and industrial laboratories working in the areas of chemoinformatics, medicinal and pharmaceutical chemistry and pharmacoinformatics.
650 0 $a Drug development. $3 190608
650 0 $a Structural bioinformatics. $3 224996
650 0 $a Cheminformatics. $3 225269
650 1 4 $a Computer Applications in Chemistry. $3 273872
650 2 4 $a Pharmaceutical Sciences/Technology. $3 338426
650 2 4 $a Protein-Ligand Interactions. $3 348845
650 2 4 $a Computational Biology/Bioinformatics. $3 274833
650 2 4 $a Medicinal Chemistry. $3 275183
700 1 $a Mohan, C. Gopi. $3 837177
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer eBooks
830 0 $a Challenges and advances in computational chemistry and physics ; $v v.11 $3 591918
856 4 0 $u https://doi.org/10.1007/978-3-030-05282-9
950 $a Chemistry and Materials Science (Springer-11644)