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Polymyxin antibioticsfrom laboratory...

Kaye, Keith S.

Polymyxin antibioticsfrom laboratory bench to bedside /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Polymyxin antibioticsedited by Jian Li, Roger L. Nation, Keith S. Kaye.
Reminder of title:	from laboratory bench to bedside /
other author:	Li, Jian.
Published:	Cham :Springer International Publishing :2019.
Description:	viii, 366 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Polymyxin.
Online resource:	https://doi.org/10.1007/978-3-030-16373-0
ISBN:	9783030163730$q(electronic bk.)

Polymyxin antibioticsfrom laboratory bench to bedside /
Polymyxin antibioticsfrom laboratory bench to bedside /[electronic resource] :edited by Jian Li, Roger L. Nation, Keith S. Kaye. - Cham :Springer International Publishing :2019. - viii, 366 p. :ill. (some col.), digital ;24 cm. - Advances in experimental medicine and biology,v.11450065-2598 ;. - Advances in experimental medicine and biology ;946..

Overview -- Multidrug resistant Gram-negative pathogens: the urgent need for 'old' polymyxins -- Discovery, antibacterial spectrum and chemistry -- Mechanisms of antibacterial activity -- Mechanisms of resistance -- Bioanalysis and stability of polymyxins -- In vitro pharmacodynamics and PK/PD in animals -- Antibacterial susceptibility breakpoints -- Labeling of parenteral products of colistin methanesulfonate -- Meta-analysis of polymyxin use in patients -- Clinical use of colistin -- Clinical use of polymyxin B -- Pharmacokinetics, pharmacodynamics, toxicodynamics and dosing recommendations -- Rational combinations with other antibiotics -- Toxicities in patients: management and mechanisms -- Antiendotoxin effect -- Discovery of novel polymyxin-like antibiotics -- Conclusion.

This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researchers and clinicians in the field. It is our wish that readers discover the importance of polymyxin structure in relation to the mechanisms of activity, resistance and toxicity. We emphasized that reliable analytic methods for polymyxins are critical when investigating their pharmacokinetics (PK) and pharmacodynamics (PD) The complicated dose definitions and different pharmacopoeial standards have already compromised the safe use of polymyxins in patients. Therefore, informed by the latest pharmacological information, scientifically-based dosing recommendations have been proposed for intravenous polymyxins. Considering the PK/PD limitations and potential development of resistance, polymyxin combinations are encouraged; however, the current literature has not shown definite microbiological benefits, possibly because most clinical studies to date overlooked key PK/PD principles. Nephrotoxicity is the major dose-limiting factor and it is imperative to elucidate the mechanisms and develop novel approaches to minimize polymyxin-associated toxicities. In addition, the anti-endotoxin effect of polymyxins supports their clinical use to treat Gram-negative sepsis. Fortunately, the discovery of new-generation polymyxins with wider therapeutic windows has benefited from the latest achievements in polymyxin research. This book provides extensive pharmacological information on polymyxins to infectious diseases clinicians, pharmacists, clinical microbiologists, antimicrobial pharmacologists, and pharmaceutical scientists, and is an essential read for those who aim to develop novel polymyxins and improve their clinical use as a last-line defense against Gram-negative 'superbugs'.

ISBN: 9783030163730$q(electronic bk.)

Standard No.: 10.1007/978-3-030-16373-0doiSubjects--Topical Terms:

849207
Polymyxin.

LC Class. No.: RM267 / .P659 2019

Dewey Class. No.: 615.7922

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245 0 0 $a Polymyxin antibiotics $h [electronic resource] : $b from laboratory bench to bedside / $c edited by Jian Li, Roger L. Nation, Keith S. Kaye.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2019.
300 $a viii, 366 p. : $b ill. (some col.), digital ; $c 24 cm.
490 1 $a Advances in experimental medicine and biology, $x 0065-2598 ; $v v.1145
505 0 $a Overview -- Multidrug resistant Gram-negative pathogens: the urgent need for 'old' polymyxins -- Discovery, antibacterial spectrum and chemistry -- Mechanisms of antibacterial activity -- Mechanisms of resistance -- Bioanalysis and stability of polymyxins -- In vitro pharmacodynamics and PK/PD in animals -- Antibacterial susceptibility breakpoints -- Labeling of parenteral products of colistin methanesulfonate -- Meta-analysis of polymyxin use in patients -- Clinical use of colistin -- Clinical use of polymyxin B -- Pharmacokinetics, pharmacodynamics, toxicodynamics and dosing recommendations -- Rational combinations with other antibiotics -- Toxicities in patients: management and mechanisms -- Antiendotoxin effect -- Discovery of novel polymyxin-like antibiotics -- Conclusion.
520 $a This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researchers and clinicians in the field. It is our wish that readers discover the importance of polymyxin structure in relation to the mechanisms of activity, resistance and toxicity. We emphasized that reliable analytic methods for polymyxins are critical when investigating their pharmacokinetics (PK) and pharmacodynamics (PD) The complicated dose definitions and different pharmacopoeial standards have already compromised the safe use of polymyxins in patients. Therefore, informed by the latest pharmacological information, scientifically-based dosing recommendations have been proposed for intravenous polymyxins. Considering the PK/PD limitations and potential development of resistance, polymyxin combinations are encouraged; however, the current literature has not shown definite microbiological benefits, possibly because most clinical studies to date overlooked key PK/PD principles. Nephrotoxicity is the major dose-limiting factor and it is imperative to elucidate the mechanisms and develop novel approaches to minimize polymyxin-associated toxicities. In addition, the anti-endotoxin effect of polymyxins supports their clinical use to treat Gram-negative sepsis. Fortunately, the discovery of new-generation polymyxins with wider therapeutic windows has benefited from the latest achievements in polymyxin research. This book provides extensive pharmacological information on polymyxins to infectious diseases clinicians, pharmacists, clinical microbiologists, antimicrobial pharmacologists, and pharmaceutical scientists, and is an essential read for those who aim to develop novel polymyxins and improve their clinical use as a last-line defense against Gram-negative 'superbugs'.
650 0 $a Polymyxin. $3 849207
650 0 $a Antibiotics. $3 220398
650 1 4 $a Bacteriology. $3 273947
650 2 4 $a Pharmacotherapy. $3 615025
650 2 4 $a Drug Resistance. $3 338425
700 1 $a Li, Jian. $3 246220
700 1 $a Nation, Roger L. $3 849205
700 1 $a Kaye, Keith S. $3 849206
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer eBooks
830 0 $a Advances in experimental medicine and biology ; $v 946. $3 557559
856 4 0 $u https://doi.org/10.1007/978-3-030-16373-0
950 $a Biomedical and Life Sciences (Springer-11642)