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Actin polymerization in apicomplexan...

Kale, Avinash.

Actin polymerization in apicomplexana structural, functional and evolutionary analysis /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Actin polymerization in apicomplexanedited by Avinash Kale.
Reminder of title:	a structural, functional and evolutionary analysis /
other author:	Kale, Avinash.
Published:	Singapore :Springer Singapore :2019.
Description:	xi, 101 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Apicomplexa.
Online resource:	https://doi.org/10.1007/978-981-13-7450-0
ISBN:	9789811374500$q(electronic bk.)

Actin polymerization in apicomplexana structural, functional and evolutionary analysis /
Actin polymerization in apicomplexana structural, functional and evolutionary analysis /[electronic resource] :edited by Avinash Kale. - Singapore :Springer Singapore :2019. - xi, 101 p. :ill., digital ;24 cm.

Chapter 1. Synthesis and Characterization of nano Apicomplexan motility: A cellular perspective particles -- Chapter 2. Introduction: Gliding Motility- The model and the mechanism -- Chapter 3. Actin: The central ubiquitous player in the phenomenon -- Chapter 4. Formin: The multidomain elongator of polymer -- Chapter 5. Profilin: The associates of Formin -- Chapter 6. ADF (Actin Depolymerizing Factor): The breaker of the polymer in homeostasis -- Chapter 7. Cyclase associated protein (CAP): The silent worker -- Chapter 8. Capping Protein (CP): The formin competitor -- Chapter 9. Coronin: An Overview -- Chapter 10. Mathematical Model: A revelation of synergistic cross talks between the actin regulators -- Chapter 11. Evolution: The hallmarks of Gliding motility in apicomplexan.

This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPa and CPβ), cyclase-associated protein (CAP) and coronin 13-24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design. Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.

ISBN: 9789811374500$q(electronic bk.)

Standard No.: 10.1007/978-981-13-7450-0doiSubjects--Topical Terms:

855030
Apicomplexa.

LC Class. No.: QL368.A16 / A285 2019

Dewey Class. No.: 579.4

Actin polymerization in apicomplexana structural, functional and evolutionary analysis /
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245 0 0 $a Actin polymerization in apicomplexan $h [electronic resource] : $b a structural, functional and evolutionary analysis / $c edited by Avinash Kale.
260 $a Singapore : $b Springer Singapore : $b Imprint: Springer, $c 2019.
300 $a xi, 101 p. : $b ill., digital ; $c 24 cm.
505 0 $a Chapter 1. Synthesis and Characterization of nano Apicomplexan motility: A cellular perspective particles -- Chapter 2. Introduction: Gliding Motility- The model and the mechanism -- Chapter 3. Actin: The central ubiquitous player in the phenomenon -- Chapter 4. Formin: The multidomain elongator of polymer -- Chapter 5. Profilin: The associates of Formin -- Chapter 6. ADF (Actin Depolymerizing Factor): The breaker of the polymer in homeostasis -- Chapter 7. Cyclase associated protein (CAP): The silent worker -- Chapter 8. Capping Protein (CP): The formin competitor -- Chapter 9. Coronin: An Overview -- Chapter 10. Mathematical Model: A revelation of synergistic cross talks between the actin regulators -- Chapter 11. Evolution: The hallmarks of Gliding motility in apicomplexan.
520 $a This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPa and CPβ), cyclase-associated protein (CAP) and coronin 13-24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design. Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.
650 0 $a Apicomplexa. $3 855030
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650 2 4 $a Biomechanics. $3 188942
650 2 4 $a Protein Science. $3 376428
650 2 4 $a Protein Structure. $3 348844
650 2 4 $a Bioinformatics. $3 194415
700 1 $a Kale, Avinash. $3 855029
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