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Molecular genetics of inflammatory b...

D'Amato, Mauro.

Molecular genetics of inflammatory bowel disease

Record Type:	Electronic resources : Monograph/item
Title/Author:	Molecular genetics of inflammatory bowel diseaseedited by Charlotte Hedin, John D. Rioux, Mauro D'Amato.
other author:	Hedin, Charlotte.
Published:	Cham :Springer International Publishing :2019.
Description:	x, 402 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Inflammatory bowel diseasesGenetic aspects.
Online resource:	https://doi.org/10.1007/978-3-030-28703-0
ISBN:	9783030287030$q(electronic bk.)

Molecular genetics of inflammatory bowel disease
Molecular genetics of inflammatory bowel disease[electronic resource] /edited by Charlotte Hedin, John D. Rioux, Mauro D'Amato. - 2nd ed. - Cham :Springer International Publishing :2019. - x, 402 p. :ill., digital ;24 cm.

Part 1: The Foundation of IBD Genetics, Human and Animal Studies -- A Primer on IBD: Phenotypes, Diagnosis, Treatment and Clinical Challenges -- Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies -- Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease -- Part 2: The Genetic and Molecular Makeup of Inflammatory Bowel Disease -- Complex Disease Genes and their Discovery -- The Genetics of Crohn's Disease -- Genetics of Ulcerative Colitis -- Genetic Overlap between Inflammatory Bowel Disease and Other Diseases -- Molecular Profiling of IBD Subtypes/Response to Therapy -- Epigenetics of Inflammatory Bowel Disease -- Part 3: Pathogenetic Pathways in Inflammatory Bowel Disease -- Nod1 and Nod2 and the Immune Response to Bacteria -- The IL-23-Th17 Axis in Intestinal Inflammation -- Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics -- The Epithelial Barrier -- Host Interactions with Bacteria: From "Entente Cordiale" to "Casus Belli" -- Cytokines in Inflammatory Bowel Disease -- Part 4: Concluding Remarks and Future Perspectives -- Towards Personalized Therapy in Inflammatory Bowel Disease -- Index.

Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD. Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn's disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD. State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students.

ISBN: 9783030287030$q(electronic bk.)

Standard No.: 10.1007/978-3-030-28703-0doiSubjects--Topical Terms:

855146
Inflammatory bowel diseases
--Genetic aspects.

LC Class. No.: RC862.I53 / M65 2019

Dewey Class. No.: 616.344042

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245 0 0 $a Molecular genetics of inflammatory bowel disease $h [electronic resource] / $c edited by Charlotte Hedin, John D. Rioux, Mauro D'Amato.
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505 0 $a Part 1: The Foundation of IBD Genetics, Human and Animal Studies -- A Primer on IBD: Phenotypes, Diagnosis, Treatment and Clinical Challenges -- Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies -- Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease -- Part 2: The Genetic and Molecular Makeup of Inflammatory Bowel Disease -- Complex Disease Genes and their Discovery -- The Genetics of Crohn's Disease -- Genetics of Ulcerative Colitis -- Genetic Overlap between Inflammatory Bowel Disease and Other Diseases -- Molecular Profiling of IBD Subtypes/Response to Therapy -- Epigenetics of Inflammatory Bowel Disease -- Part 3: Pathogenetic Pathways in Inflammatory Bowel Disease -- Nod1 and Nod2 and the Immune Response to Bacteria -- The IL-23-Th17 Axis in Intestinal Inflammation -- Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics -- The Epithelial Barrier -- Host Interactions with Bacteria: From "Entente Cordiale" to "Casus Belli" -- Cytokines in Inflammatory Bowel Disease -- Part 4: Concluding Remarks and Future Perspectives -- Towards Personalized Therapy in Inflammatory Bowel Disease -- Index.
520 $a Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD. Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn's disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD. State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students.
650 0 $a Inflammatory bowel diseases $x Genetic aspects. $3 855146
650 0 $a Inflammatory bowel diseases $x Molecular aspects. $3 855147
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650 2 4 $a Gastroenterology. $3 274091
700 1 $a Hedin, Charlotte. $3 855143
700 1 $a Rioux, John D. $3 855144
700 1 $a D'Amato, Mauro. $3 855145
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856 4 0 $u https://doi.org/10.1007/978-3-030-28703-0
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