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Protein allostery in drug discovery

Nussinov, Ruth.

Protein allostery in drug discovery

Record Type:	Electronic resources : Monograph/item
Title/Author:	Protein allostery in drug discoveryedited by Jian Zhang, Ruth Nussinov.
other author:	Zhang, Jian.
Published:	Singapore :Springer Singapore :2019.
Description:	xii, 384 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Allosteric proteins.
Online resource:	https://doi.org/10.1007/978-981-13-8719-7
ISBN:	9789811387197$q(electronic bk.)

Protein allostery in drug discovery
Protein allostery in drug discovery[electronic resource] /edited by Jian Zhang, Ruth Nussinov. - Singapore :Springer Singapore :2019. - xii, 384 p. :ill. (some col.), digital ;24 cm. - Advances in experimental medicine and biology,v.11630065-2598 ;. - Advances in experimental medicine and biology ;946..

The book focuses on protein allostery in drug discovery. Allosteric regulation, ?the second secret of life?, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery-as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.

ISBN: 9789811387197$q(electronic bk.)

Standard No.: 10.1007/978-981-13-8719-7doiSubjects--Topical Terms:

855201
Allosteric proteins.

LC Class. No.: QP552.A436 / P768 2019

Dewey Class. No.: 572.6

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520 $a The book focuses on protein allostery in drug discovery. Allosteric regulation, ?the second secret of life?, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery-as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.
650 0 $a Allosteric proteins. $3 855201
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