國立高雄大學圖資館 |

語系: 繁體中文

說明(常見問題)

圖資館首頁

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

HSF1 and molecular chaperones in bio...

Mendillo, Marc Laurence.

HSF1 and molecular chaperones in biology and cancer

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	HSF1 and molecular chaperones in biology and canceredited by Marc Laurence Mendillo, David Pincus, Ruth Scherz-Shouval.
其他作者:	Mendillo, Marc Laurence.
出版者:	Cham :Springer International Publishing :2020.
面頁冊數:	viii, 182 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
標題:	Molecular chaperones.
電子資源:	https://doi.org/10.1007/978-3-030-40204-4
ISBN:	9783030402044$q(electronic bk.)

HSF1 and molecular chaperones in biology and cancer
HSF1 and molecular chaperones in biology and cancer[electronic resource] /edited by Marc Laurence Mendillo, David Pincus, Ruth Scherz-Shouval. - Cham :Springer International Publishing :2020. - viii, 182 p. :ill. (some col.), digital ;24 cm. - Advances in experimental medicine and biology,v.12430065-2598 ;. - Advances in experimental medicine and biology ;946..

Preface: Dedication to Susan Lindquist -- Part I: Structure -- Structural and Biochemical properties of Hsp40/Hsp70 chaperone system -- The TRiC/CCT chaperonin and its role in uncontrolled proliferation -- Regulation of Hsf1 and the heat shock response -- Part II: Function -- Challenging proteostasis: Role of the chaperone network to control aggregation-prone proteins in human disease -- The multifaceted role of HSF1 in tumorigenesis -- Chaperome networks - redundancy and implications for cancer treatment -- Chaperones in the tumor microenvironment -- The impact of the ER unfolded protein response on cancer initiation and progression: Therapeutic implications -- Part III: Therapies -- The right tool for the job: an overview of Hsp90 inhibitors -- Lessons learned from proteasome inhibitors, the paradigm for targeting protein homeostasis in cancer -- Reflections and outlook on targeting HSP90, HSP70 and HSF1 in cancer: A personal perspective.

Protein homeostasis, or "Proteostasis", lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease.

ISBN: 9783030402044$q(electronic bk.)

Standard No.: 10.1007/978-3-030-40204-4doiSubjects--Topical Terms:

188662
Molecular chaperones.

LC Class. No.: QP552.M64 / H743 2020

Dewey Class. No.: 572.633

HSF1 and molecular chaperones in biology and cancer
LDR:03517nmm a2200337 a 4500 001 571673
003 DE-He213
005 20200810170756.0
006 m d
007 cr nn 008maaau
008 200922s2020 sz s 0 eng d
020 $a 9783030402044$q(electronic bk.)
020 $a 9783030402037$q(paper)
024 7 $a 10.1007/978-3-030-40204-4 $2 doi
035 $a 978-3-030-40204-4
040 $a GP $c GP
041 0 $a eng
050 4 $a QP552.M64 $b H743 2020
072 7 $a MFN $2 bicssc
072 7 $a MED107000 $2 bisacsh
072 7 $a MFN $2 thema
082 0 4 $a 572.633 $2 23
090 $a QP552.M64 $b H873 2020
245 0 0 $a HSF1 and molecular chaperones in biology and cancer $h [electronic resource] / $c edited by Marc Laurence Mendillo, David Pincus, Ruth Scherz-Shouval.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2020.
300 $a viii, 182 p. : $b ill. (some col.), digital ; $c 24 cm.
490 1 $a Advances in experimental medicine and biology, $x 0065-2598 ; $v v.1243
505 0 $a Preface: Dedication to Susan Lindquist -- Part I: Structure -- Structural and Biochemical properties of Hsp40/Hsp70 chaperone system -- The TRiC/CCT chaperonin and its role in uncontrolled proliferation -- Regulation of Hsf1 and the heat shock response -- Part II: Function -- Challenging proteostasis: Role of the chaperone network to control aggregation-prone proteins in human disease -- The multifaceted role of HSF1 in tumorigenesis -- Chaperome networks - redundancy and implications for cancer treatment -- Chaperones in the tumor microenvironment -- The impact of the ER unfolded protein response on cancer initiation and progression: Therapeutic implications -- Part III: Therapies -- The right tool for the job: an overview of Hsp90 inhibitors -- Lessons learned from proteasome inhibitors, the paradigm for targeting protein homeostasis in cancer -- Reflections and outlook on targeting HSP90, HSP70 and HSF1 in cancer: A personal perspective.
520 $a Protein homeostasis, or "Proteostasis", lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease.
650 0 $a Molecular chaperones. $3 188662
650 1 4 $a Human Genetics. $3 273658
650 2 4 $a Cancer Research. $3 273660
650 2 4 $a Molecular Medicine. $3 273932
650 2 4 $a Proteomics. $3 220403
650 2 4 $a Protein Science. $3 376428
650 2 4 $a Protein Structure. $3 348844
700 1 $a Mendillo, Marc Laurence. $3 858416
700 1 $a Pincus, David. $3 858417
700 1 $a Scherz-Shouval, Ruth. $3 858418
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer eBooks
830 0 $a Advances in experimental medicine and biology ; $v 946. $3 557559
856 4 0 $u https://doi.org/10.1007/978-3-030-40204-4
950 $a Biomedical and Life Sciences (Springer-11642)