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Human population genetics and genomics

Templeton, Alan Robert,

Human population genetics and genomics

Record Type:	Electronic resources : Monograph/item
Title/Author:	Human population genetics and genomicsAlan R. Templeton.
Author:	Templeton, Alan Robert,
Published:	London :Academic Press,2019.
Description:	1 online resource.
Subject:	Human population genetics.
Online resource:	https://www.sciencedirect.com/science/book/9780123860255
ISBN:	9780123860262 (electronic bk.)

Human population genetics and genomics
Templeton, Alan Robert,

Human population genetics and genomics[electronic resource] /Alan R. Templeton. - London :Academic Press,2019. - 1 online resource.

Includes bibliographical references and index.

Front Cover; Human Population Genetics and Genomics; Human Population Genetics and Genomics; Copyright; Dedication; Contents; Preface; 1 -- DEFINITION, SCOPE, AND PREMISES OF HUMAN POPULATION GENETICS; THE BASIC PREMISES OF POPULATION GENETICS; PREMISE 1: DNA CAN REPLICATE; PREMISE 2: DNA CAN MUTATE AND RECOMBINE; PREMISE 3: DNA AND THE ENVIRONMENT INTERACT TO PRODUCE PHENOTYPES; NATURAL SELECTION AND THE INTEGRATION OF THE THREE PREMISES; REFERENCES; 2 -- THE HUMAN GENOME; COMPONENTS OF THE NUCLEAR GENOME; GENES; TRANSPOSABLE ELEMENTS; REPETITIVE DNA; CG ISLANDS; CENTROMERES; TELOMERES.

Human Population Genetics and Genomics provides researchers/students with knowledge on population genetics and relevant statistical approaches to help them become more effective users of modern genetic, genomic and statistical tools. In-depth chapters offer thorough discussions of systems of mating, genetic drift, gene flow and subdivided populations, human population history, genotype and phenotype, detecting selection, units and targets of natural selection, adaptation to temporally and spatially variable environments, selection in age-structured populations, and genomics and society. As human genetics and genomics research often employs tools and approaches derived from population genetics, this book helps users understand the basic principles of these tools. In addition, studies often employ statistical approaches and analysis, so an understanding of basic statistical theory is also needed.

ISBN: 9780123860262 (electronic bk.)Subjects--Topical Terms:

494576
Human population genetics.
Index Terms--Genre/Form:

214472
Electronic books.

LC Class. No.: GN289

Dewey Class. No.: 576.58

Human population genetics and genomics
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100 1 $a Templeton, Alan Robert, $e author. $3 872084
245 1 0 $a Human population genetics and genomics $h [electronic resource] / $c Alan R. Templeton.
260 $a London : $b Academic Press, $c 2019.
300 $a 1 online resource.
504 $a Includes bibliographical references and index.
505 0 $a Front Cover; Human Population Genetics and Genomics; Human Population Genetics and Genomics; Copyright; Dedication; Contents; Preface; 1 -- DEFINITION, SCOPE, AND PREMISES OF HUMAN POPULATION GENETICS; THE BASIC PREMISES OF POPULATION GENETICS; PREMISE 1: DNA CAN REPLICATE; PREMISE 2: DNA CAN MUTATE AND RECOMBINE; PREMISE 3: DNA AND THE ENVIRONMENT INTERACT TO PRODUCE PHENOTYPES; NATURAL SELECTION AND THE INTEGRATION OF THE THREE PREMISES; REFERENCES; 2 -- THE HUMAN GENOME; COMPONENTS OF THE NUCLEAR GENOME; GENES; TRANSPOSABLE ELEMENTS; REPETITIVE DNA; CG ISLANDS; CENTROMERES; TELOMERES.
505 8 $a THE TRANSCRIPTOMETHE EXOME, SPLICEOSOME, AND PROTEOME; EPIGENOME; THE MITOCHONDRIAL GENOME; MUTATION AND RECOMBINATION IN THE HUMAN GENOMES; MUTATION; RECOMBINATION; REFERENCES; 3 -- SYSTEMS OF MATING; RANDOM MATING AND THE HARDY-WEINBERG LAW; INBREEDING; PEDIGREE INBREEDING; SYSTEM OF MATING INBREEDING; ASSORTATIVE MATING; DISASSORTATIVE MATING; COEXISTENCE OF MULTIPLE SYSTEMS OF MATING WITHIN A DEME; REFERENCES; 4 -- GENETIC DRIFT; THE FATE OF A NEWLY ARISEN MUTATION IN A LARGE POPULATION; GENETIC DRIFT IN A FINITE POPULATION;EFFECTIVE POPULATION SIZES.
505 8 $a GENETIC DRIFT AND LINKAGE DISEQUILIBRIUMGENETIC DRIFT AND NEUTRAL MUTATIONS; REFERENCES; 5 -- A BACKWARD VIEW OF GENETIC DRIFT: COALESCENCE; BASIC COALESCENT MODEL; COALESCENCE WITH MUTATION; HAPLOTYPE TREES; HAPLOTYPE TREES, POPULATION TREES, AND SPECIES TREES; COALESCENCE AND RECOMBINATION; REFERENCES; 6 -- GENE FLOW AND SUBDIVIDED POPULATIONS; A TWO-DEME MODEL OF GENE FLOW; THE BALANCE OF GENE FLOW AND GENETIC DRIFT; GENDER-BIASED GENE FLOW; SYSTEM OF MATING AND GENE FLOW; KIN-STRUCTURED MIGRATION; ADMIXTURE; ISOLATION BY DISTANCE AND RESISTANCE; IDENTIFYING HUMAN SUBPOPULATIONS.
505 8 $a POPULATION SUBDIVISION, ISOLATION-BY-DISTANCE, AND EFFECTIVE POPULATION SIZESREFERENCES; 7 -- HUMAN POPULATION HISTORY OVER THE LAST TWO MILLION YEARS; HAPLOTYPE TREES AS A WINDOW INTO THE PAST; POPULATION TREES; ANCIENT DNA-THE ORIGINS OF THE HUMAN GENE POOL; ANCIENT DNA-THE LAST 25,000YEARS; REFERENCES; 8 -- GENOTYPE AND PHENOTYPE; FISHER'S QUANTITATIVE GENETIC MODEL; CLASSICAL HUMAN QUANTITATIVE GENETIC ANALYSIS; MEASURED GENOTYPE APPROACHES TO QUANTITATIVE GENETICS; LINKAGE MAPPING; RUNS OF HOMOZYGOSITY; ADMIXTURE MAPPING; GENOME-WIDEASSOCIATION STUDIES.
505 8 $a CLASSICAL QUANTITATIVE GENETICS VERSUS MEASURED GENOTYPE APPROACHESREFERENCES; 9 -- NATURAL SELECTION; A ONE-LOCUS, TWO-ALLELE MODEL OF NATURAL SELECTION; SICKLE-CELL AND MALARIAL ADAPTATIONS: AN EXAMPLE OF THE MEASURED GENOTYPE APPROACH TO NATURAL SELECTION; A QUANTITATIVE GENETIC, UNMEASURED GENOTYPE MODEL OF NATURAL SELECTION; REFERENCES; 10 -- DETECTING SELECTION THROUGH ITS INTERACTIONS WITH OTHER EVOLUTIONARY FORCES; INTERACTION OF SELECTION WITH MUTATION; INTERACTIONS OF SELECTION WITH MUTATION AND GENETIC DRIFT; INTERACTIONS OF SELECTION WITHMUTATION, GENETIC DRIFT, AND RECOMBINATION.
520 $a Human Population Genetics and Genomics provides researchers/students with knowledge on population genetics and relevant statistical approaches to help them become more effective users of modern genetic, genomic and statistical tools. In-depth chapters offer thorough discussions of systems of mating, genetic drift, gene flow and subdivided populations, human population history, genotype and phenotype, detecting selection, units and targets of natural selection, adaptation to temporally and spatially variable environments, selection in age-structured populations, and genomics and society. As human genetics and genomics research often employs tools and approaches derived from population genetics, this book helps users understand the basic principles of these tools. In addition, studies often employ statistical approaches and analysis, so an understanding of basic statistical theory is also needed.
588 0 $a Online resource; title from PDF file page (EBSCO, viewed November 14, 2018).
650 0 $a Human population genetics. $3 494576
650 0 $a Human genetics. $3 192904
655 4 $a Electronic books. $2 local. $3 214472
856 4 0 $u https://www.sciencedirect.com/science/book/9780123860255