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Principles and applications of clini...

Hoofnagle, Andy N.,

Principles and applications of clinical mass spectrometrysmall molecules, peptides, and pathogens /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Principles and applications of clinical mass spectrometryedited by Nader Rifai, PhD, Andrea Rita Horvath, MD, PhD, Carl T. Wittwer MD, PhD ; associate editor Andrew N. Hoofnagle, MD, PhD.
Reminder of title:	small molecules, peptides, and pathogens /
other author:	Rifai, Nader,
Published:	Amsterdam, Netherlands ;Elsevier,2018.
Description:	1 online resource.
Subject:	Mass spectrometry.
Online resource:	https://www.sciencedirect.com/science/book/9780128160633
ISBN:	9780128160640 (electronic bk.)

Principles and applications of clinical mass spectrometrysmall molecules, peptides, and pathogens /
Principles and applications of clinical mass spectrometrysmall molecules, peptides, and pathogens /[electronic resource] :edited by Nader Rifai, PhD, Andrea Rita Horvath, MD, PhD, Carl T. Wittwer MD, PhD ; associate editor Andrew N. Hoofnagle, MD, PhD. - Amsterdam, Netherlands ;Elsevier,2018. - 1 online resource.

Includes bibliographical references and index.

Intro; Title page; Table of Contents; Copyright; Contributors; Preface; 1. Chromatography; Basic Principles of Chromatography; Gas Chromatography; Liquid Chromatography; Other Chromatographic Methods; 2. Mass Spectrometry; Basic Concepts and Definitions; Instrumentation; Clinical Applications; Optimization of Instrument Conditions; 3. Sample Preparation for Mass Spectrometry Applications; Background; General Techniques; Separation Techniques; Precipitation Techniques; Enrichment Techniques; Extraction Techniques; Chromatographic Techniques; Evolving Techniques

Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens, derived from the Sixth Edition of the bestselling Tietz Textbook of Clinical Chemistry and Molecular Diagnostics is a concise resource for the quick implementation of mass spectrometry methods in clinical laboratory work. Focusing on the practical use of these techniques, the book covers principles of chromatographic separations and types of mass spectrometers, along with sample preparations for analysis. Additional sections provide guidance on the use of the technology in the main applications in the clinical lab, including determination of small molecules and peptides, and in pathogen identification. Provides concrete examples on the main applications of this technologyAuthored, and edited, by the top experts in the United StatesDescribes the current capabilities of the LC- and MS-based analytical methods, along with the recipes for successful analytical work in the field

ISBN: 9780128160640 (electronic bk.)Subjects--Topical Terms:

194021
Mass spectrometry.
Index Terms--Genre/Form:

214472
Electronic books.

LC Class. No.: QD96.M3

Dewey Class. No.: 543/.65

Principles and applications of clinical mass spectrometrysmall molecules, peptides, and pathogens /
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245 0 0 $a Principles and applications of clinical mass spectrometry $h [electronic resource] : $b small molecules, peptides, and pathogens / $c edited by Nader Rifai, PhD, Andrea Rita Horvath, MD, PhD, Carl T. Wittwer MD, PhD ; associate editor Andrew N. Hoofnagle, MD, PhD.
260 $a Amsterdam, Netherlands ; $a Oxford, United Kingdom ; $a Cambridge, MA, United States : $b Elsevier, $c 2018.
300 $a 1 online resource.
504 $a Includes bibliographical references and index.
505 0 $a Intro; Title page; Table of Contents; Copyright; Contributors; Preface; 1. Chromatography; Basic Principles of Chromatography; Gas Chromatography; Liquid Chromatography; Other Chromatographic Methods; 2. Mass Spectrometry; Basic Concepts and Definitions; Instrumentation; Clinical Applications; Optimization of Instrument Conditions; 3. Sample Preparation for Mass Spectrometry Applications; Background; General Techniques; Separation Techniques; Precipitation Techniques; Enrichment Techniques; Extraction Techniques; Chromatographic Techniques; Evolving Techniques
505 8 $a 4. Mass Spectrometry Applications in Infectious Disease and Pathogens IdentificationMatrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry; Analysis of Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry Data; Electrospray Ionization Mass Spectrometry; Conclusions; 5. Development and Validation of Small Molecule Analytes by Liquid Chromatography-Tandem Mass Spectrometry; Practical Considerations for Liquid Chromatography-Tandem Mass Spectrometry Assays; Sample Preparation; 6. Proteomics; Historical Perspective; Biomarker Pipeline
505 8 $a Bottom-Up Targeted ProteomicsTop-Down Proteomics; Preanalytical and Other Technical Considerations; Conclusions; Index
520 $a Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens, derived from the Sixth Edition of the bestselling Tietz Textbook of Clinical Chemistry and Molecular Diagnostics is a concise resource for the quick implementation of mass spectrometry methods in clinical laboratory work. Focusing on the practical use of these techniques, the book covers principles of chromatographic separations and types of mass spectrometers, along with sample preparations for analysis. Additional sections provide guidance on the use of the technology in the main applications in the clinical lab, including determination of small molecules and peptides, and in pathogen identification. Provides concrete examples on the main applications of this technologyAuthored, and edited, by the top experts in the United StatesDescribes the current capabilities of the LC- and MS-based analytical methods, along with the recipes for successful analytical work in the field
588 0 $a Online resource; title from PDF title page (EBSCO, viewed June 19, 2018).
650 0 $a Mass spectrometry. $3 194021
650 0 $a Clinical chemistry. $3 240546
655 4 $a Electronic books. $2 local. $3 214472
700 1 $a Rifai, Nader, $e editor. $3 872723
700 1 $a Horvath, Andrea R. $q (Andrea Rita), $e editor. $3 872724
700 1 $a Wittwer, C. $q (Carl), $d 1955- $3 440874
700 1 $a Hoofnagle, Andy N., $e associate editor. $3 872725
856 4 0 $u https://www.sciencedirect.com/science/book/9780128160633