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The pulmonary neuroepithelial body m...

Brouns, Inge.

The pulmonary neuroepithelial body microenvironmenta multifunctional unit in the airway epithelium /

Record Type:	Electronic resources : Monograph/item
Title/Author:	The pulmonary neuroepithelial body microenvironmentby Inge Brouns ... [et al.].
Reminder of title:	a multifunctional unit in the airway epithelium /
other author:	Brouns, Inge.
Published:	Cham :Springer International Publishing :2021.
Description:	xviii, 99 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer Nature eBook
Subject:	Pulmonary endotheliumMolecular aspects.
Online resource:	https://doi.org/10.1007/978-3-030-65817-5
ISBN:	9783030658175$q(electronic bk.)

The pulmonary neuroepithelial body microenvironmenta multifunctional unit in the airway epithelium /
The pulmonary neuroepithelial body microenvironmenta multifunctional unit in the airway epithelium /[electronic resource] :by Inge Brouns ... [et al.]. - Cham :Springer International Publishing :2021. - xviii, 99 p. :ill. (some col.), digital ;24 cm. - Advances in anatomy, embryology and cell biology,2330301-5556 ;. - Advances in anatomy, embryology and cell biology ;211..

Pulmonary sensory receptors -- The pulmonary NEB ME is a complex intraepithelial unit -- Studying the pulmonary NEB ME: a multidisciplinary approach -- Functional exploration of the pulmonary NEB ME -- Concluding remarks and future perspectives -- References -- ADDENDUM.

This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors.

ISBN: 9783030658175$q(electronic bk.)

Standard No.: 10.1007/978-3-030-65817-5doiSubjects--Topical Terms:

891970
Pulmonary endothelium
--Molecular aspects.

LC Class. No.: QP88.45

Dewey Class. No.: 616.02774

The pulmonary neuroepithelial body microenvironmenta multifunctional unit in the airway epithelium /
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300 $a xviii, 99 p. : $b ill. (some col.), digital ; $c 24 cm.
490 1 $a Advances in anatomy, embryology and cell biology, $x 0301-5556 ; $v 233
505 0 $a Pulmonary sensory receptors -- The pulmonary NEB ME is a complex intraepithelial unit -- Studying the pulmonary NEB ME: a multidisciplinary approach -- Functional exploration of the pulmonary NEB ME -- Concluding remarks and future perspectives -- References -- ADDENDUM.
520 $a This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors.
650 0 $a Pulmonary endothelium $x Molecular aspects. $3 891970
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650 2 4 $a Physiology. $3 192980
650 2 4 $a Neurochemistry. $3 197640
650 2 4 $a Pneumology/Respiratory System. $3 274253
700 1 $a Brouns, Inge. $3 558313
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