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Human papillomavirusproving and usin...

Bosch, F. Xavier.

Human papillomavirusproving and using a viral cause for cancer /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Human papillomavirus[edited by] David Jenkins, F. Xavier Bosch.
Reminder of title:	proving and using a viral cause for cancer /
other author:	Jenkins, David
Published:	London ;Academic Press,2020.
Description:	1 online resource.
Subject:	Papillomaviruses.
Online resource:	https://www.sciencedirect.com/science/book/9780128144572
ISBN:	9780128144862 (electronic bk.)

Human papillomavirusproving and using a viral cause for cancer /
Human papillomavirusproving and using a viral cause for cancer /[electronic resource] :[edited by] David Jenkins, F. Xavier Bosch. - London ;Academic Press,2020. - 1 online resource.

Section 1: Early questions and their slow answers 1. Introduction: Implications and responses to a possible specific infectious cause for a solid cancer, approaches to proving the role of HPV, and exploring its potential uses against conventional medical practice 2. Cervical and other cancers now associated with HPV prior to recognition of HPV in cervical cancer 3. Cervical screening and its basis in ideas of precancer in classical microscopic pathology 4. The "discovery" of HPV I6 in cervical cancer and studies of its transforming role, P53 and pRB 5. Growing numbers of carcinogenic papillomaviruses and understanding of their differences 6. The impact of HPV on conventional morphological pathology of cancer and precancer. Bethesda classification, molecular markers relating morphology to molecular mechanisms 7. The proof of causality in humans 8. Progression from infection to cancer 9. Sexuality and HPV: sexual transmission, male role 10. Genital warts 11. HPV and non-cervical cancer 12. Immune responses, and antibodies to HPV, making viral antigens 13. Developing and standardising HPV tests 14. HPV and non-HPV pathways to cancer Section 2: Prevention ofcancer and HPV infection 15. Introduction: Evidence-based medicine, HPV and cancer prevention 16. Triage of women with low-grade smear abnormalities and HPV testing, HC1 and 2, GP5+/6+, ALTS trial, Netherlands, other trials 17. Primaryscreening by HPV testing 18. Prophylactic vaccines, proving their value and the role and limitations of the pharmaceutical industry and its regulators, safety and efficacy 19. Modelling disease, prevention and cost-effectiveness -- a developing process, different types of models, what does cost-effectiveness mean? 20. Changing global concerns about screening and vaccination

"[This book] presents a steady and massive accumulation of evidence about the role of HPV and prevention of HPV-induced cancer, along with the role and personal commitment of many scientists of different backgrounds in establishing global relevance. This exercise involved years of personal commitment to proving or disproving an idea that aroused initial skepticism, and that still has difficult implications for some. It remains one of the big successes of medicine thatexploited both established medical science dating back to the nineteenth century and new molecular genetic science during a time of transition in medicine."--Website ebook

ISBN: 9780128144862 (electronic bk.)Subjects--Topical Terms:

569514
Papillomaviruses.
Index Terms--Genre/Form:

214472
Electronic books.

LC Class. No.: RC168.P15

Dewey Class. No.: 616.911

Human papillomavirusproving and using a viral cause for cancer /
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505 0 $a Section 1: Early questions and their slow answers 1. Introduction: Implications and responses to a possible specific infectious cause for a solid cancer, approaches to proving the role of HPV, and exploring its potential uses against conventional medical practice 2. Cervical and other cancers now associated with HPV prior to recognition of HPV in cervical cancer 3. Cervical screening and its basis in ideas of precancer in classical microscopic pathology 4. The "discovery" of HPV I6 in cervical cancer and studies of its transforming role, P53 and pRB 5. Growing numbers of carcinogenic papillomaviruses and understanding of their differences 6. The impact of HPV on conventional morphological pathology of cancer and precancer. Bethesda classification, molecular markers relating morphology to molecular mechanisms 7. The proof of causality in humans 8. Progression from infection to cancer 9. Sexuality and HPV: sexual transmission, male role 10. Genital warts 11. HPV and non-cervical cancer 12. Immune responses, and antibodies to HPV, making viral antigens 13. Developing and standardising HPV tests 14. HPV and non-HPV pathways to cancer Section 2: Prevention ofcancer and HPV infection 15. Introduction: Evidence-based medicine, HPV and cancer prevention 16. Triage of women with low-grade smear abnormalities and HPV testing, HC1 and 2, GP5+/6+, ALTS trial, Netherlands, other trials 17. Primaryscreening by HPV testing 18. Prophylactic vaccines, proving their value and the role and limitations of the pharmaceutical industry and its regulators, safety and efficacy 19. Modelling disease, prevention and cost-effectiveness -- a developing process, different types of models, what does cost-effectiveness mean? 20. Changing global concerns about screening and vaccination
520 $a "[This book] presents a steady and massive accumulation of evidence about the role of HPV and prevention of HPV-induced cancer, along with the role and personal commitment of many scientists of different backgrounds in establishing global relevance. This exercise involved years of personal commitment to proving or disproving an idea that aroused initial skepticism, and that still has difficult implications for some. It remains one of the big successes of medicine thatexploited both established medical science dating back to the nineteenth century and new molecular genetic science during a time of transition in medicine."--Website ebook
650 0 $a Papillomaviruses. $3 569514
650 0 $a Cancer $x Etiology. $3 188748
650 0 $a Cancer $x Prevention. $3 189393
650 0 $a Virology. $3 196498
650 1 2 $a Papillomavirus Infections. $3 569515
650 2 2 $a Papillomaviridae $x pathogenicity. $3 520620
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700 1 $a Jenkins, David $c (Emeritus professor of pathology) $3 897158
700 1 $a Bosch, F. Xavier. $3 897159
856 4 0 $u https://www.sciencedirect.com/science/book/9780128144572