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RNA damage and repair

Kotta-Loizou, Ioly.

RNA damage and repair

Record Type:	Electronic resources : Monograph/item
Title/Author:	RNA damage and repairedited by Ioly Kotta-Loizou.
other author:	Kotta-Loizou, Ioly.
Published:	Cham :Springer International Publishing :2021.
Description:	ix, 178 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
Subject:	RNA.
Online resource:	https://doi.org/10.1007/978-3-030-76571-2
ISBN:	9783030765712$q(electronic bk.)

RNA damage and repair
RNA damage and repair[electronic resource] /edited by Ioly Kotta-Loizou. - Cham :Springer International Publishing :2021. - ix, 178 p. :ill., digital ;24 cm.

Part 1: RNA Damage and Repair in Prokaryotes -- Chapter 1: Endoribonucleases of the toxin-antitoxin systems induce abortive infection -- Chapter 2: The lifecycle of ribosomal RNA in bacteria -- Chapter 3: The Rtc RNA end healing and sealing system -- Part 2: RNA Damage and Repair in Eukaryotes -- Chapter 4: Oxidative and nitrative RNA modifications in plants -- Chapter 5: The role of ribonucleases in RNA damage, inactivation, and degradation -- Chapter 6: Cytoplasmic mRNA recapping: An unexpected form of RNA repair -- Part 3: RNA Damage in Human Diseases -- Chapter 7: Adenosine-to-Inosine RNA editing: a key RNA processing step rewriting transcriptome in normal physiology and diseases -- Chapter 8: RNA-mediated metabolic defects in microsatellite expansion diseases.

Ribonucleic acid (RNA) is a macromolecule that plays a central role in cell physiology: RNA molecules act as intermediates between the deoxyribonucleic acid (DNA), where genetic information is stored, and proteins, which perform the necessary functions within the cell. Traditionally, the structural and functional properties of RNA are closely linked to gene expression. However, RNA-based enzymes, called ribozymes, are also involved in catalysis and small RNAs regulate key cellular processes, such as cell growth, division, differentiation, aging and death. RNA is a sensitive macromolecule that can be easily damaged by environmental conditions (ultraviolet radiation, oxidative stress) and biological factors (ribonucleases, ribotoxins, CRISPR-Cas systems) Therefore, cells have developed mechanisms to protect and/or repair RNA molecules. This book presents an overview of the biology of RNA damage, protection and repair in prokaryotes and eukaryotes. Individual chapters cover the expression regulation, enzymology and physiological role of such systems, and link them to important human diseases such as cancer and degenerative diseases.

ISBN: 9783030765712$q(electronic bk.)

Standard No.: 10.1007/978-3-030-76571-2doiSubjects--Topical Terms:

216963
RNA.

LC Class. No.: QP623

Dewey Class. No.: 572.88

RNA damage and repair
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245 0 0 $a RNA damage and repair $h [electronic resource] / $c edited by Ioly Kotta-Loizou.
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505 0 $a Part 1: RNA Damage and Repair in Prokaryotes -- Chapter 1: Endoribonucleases of the toxin-antitoxin systems induce abortive infection -- Chapter 2: The lifecycle of ribosomal RNA in bacteria -- Chapter 3: The Rtc RNA end healing and sealing system -- Part 2: RNA Damage and Repair in Eukaryotes -- Chapter 4: Oxidative and nitrative RNA modifications in plants -- Chapter 5: The role of ribonucleases in RNA damage, inactivation, and degradation -- Chapter 6: Cytoplasmic mRNA recapping: An unexpected form of RNA repair -- Part 3: RNA Damage in Human Diseases -- Chapter 7: Adenosine-to-Inosine RNA editing: a key RNA processing step rewriting transcriptome in normal physiology and diseases -- Chapter 8: RNA-mediated metabolic defects in microsatellite expansion diseases.
520 $a Ribonucleic acid (RNA) is a macromolecule that plays a central role in cell physiology: RNA molecules act as intermediates between the deoxyribonucleic acid (DNA), where genetic information is stored, and proteins, which perform the necessary functions within the cell. Traditionally, the structural and functional properties of RNA are closely linked to gene expression. However, RNA-based enzymes, called ribozymes, are also involved in catalysis and small RNAs regulate key cellular processes, such as cell growth, division, differentiation, aging and death. RNA is a sensitive macromolecule that can be easily damaged by environmental conditions (ultraviolet radiation, oxidative stress) and biological factors (ribonucleases, ribotoxins, CRISPR-Cas systems) Therefore, cells have developed mechanisms to protect and/or repair RNA molecules. This book presents an overview of the biology of RNA damage, protection and repair in prokaryotes and eukaryotes. Individual chapters cover the expression regulation, enzymology and physiological role of such systems, and link them to important human diseases such as cancer and degenerative diseases.
650 0 $a RNA. $3 216963
650 0 $a DNA damage. $3 229562
650 1 4 $a Nucleic Acid Chemistry. $3 376665
650 2 4 $a Enzymology. $3 193702
650 2 4 $a Cell Biology. $3 274165
650 2 4 $a Microbiology. $3 192943
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