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Resistance to targeted therapies in ...

Ling, Silvia CW.

Resistance to targeted therapies in multiple myeloma

Record Type:	Electronic resources : Monograph/item
Title/Author:	Resistance to targeted therapies in multiple myelomaedited by Silvia CW Ling, Steven Trieu.
other author:	Ling, Silvia CW.
Published:	Cham :Springer International Publishing :2021.
Description:	xvii, 154 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
Subject:	Drug resistance in cancer cells.
Online resource:	https://doi.org/10.1007/978-3-030-73440-4
ISBN:	9783030734404$q(electronic bk.)

Resistance to targeted therapies in multiple myeloma
Resistance to targeted therapies in multiple myeloma[electronic resource] /edited by Silvia CW Ling, Steven Trieu. - Cham :Springer International Publishing :2021. - xvii, 154 p. :ill., digital ;24 cm. - Resistance to targeted anti-cancer therapeutics,v.222196-5501 ;. - Resistance to targeted anti-cancer therapeutics ;v.4..

1. The role of targeted therapy in multiple myeloma -- 2. Lenalidomide -- 3. Pomalidomide -- 4. Mechanisms driving resistance to proteasome inhibitors bortezomib, carfilzomib and ixazomib in multiple myeloma -- 5. Daratumumab -- 6. Elotuzumab -- 7. Histone deacetylase inhibitors -- 8. Bone targeted therapies -- 9. New targeted therapies for multiple myeloma under clinical investigation.

Multiple Myeloma remains an incurable malignancy. As the disease progresses, it invariably becomes resistant to treatment and almost all patients develop refractory disease. There are multiple different types of targeted therapies and many of them are used in combination at different stages of disease. Targeted therapies that are approved to be used include Proteasome Inhibitors, Immunomodulatory Drugs and Monoclonal Antibodies. Second and third generations of these drugs are developed to overcome resistance and they have unique mechanism of actions. Targeted therapies that are undergoing clinical trials include CAR-T cells, bi-specific antibodies, vaccines, ubiquitin ligase inhibitors and BCL-2 inhibitors. This book will help to develop an understanding of targeted therapies in Multiple Myeloma. Its goal is to provide a unique review of the mechanism of action and resistance of the many targeted therapies in Multiple Myeloma by leaders of the field. The book will be useful for students in medical science, clinicians, health professionals, scientists, pharmaceutical professionals, drug developers, and policy makers. This book will provide an insightful knowledge of the biology of Multiple Myeloma, the mechanism of action and resistance of targeted therapies, application of biomarkers and genomics and possible strategies in overcoming resistance and future development.

ISBN: 9783030734404$q(electronic bk.)

Standard No.: 10.1007/978-3-030-73440-4doiSubjects--Topical Terms:

281104
Drug resistance in cancer cells.

LC Class. No.: RC280.B6

Dewey Class. No.: 616.99418

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520 $a Multiple Myeloma remains an incurable malignancy. As the disease progresses, it invariably becomes resistant to treatment and almost all patients develop refractory disease. There are multiple different types of targeted therapies and many of them are used in combination at different stages of disease. Targeted therapies that are approved to be used include Proteasome Inhibitors, Immunomodulatory Drugs and Monoclonal Antibodies. Second and third generations of these drugs are developed to overcome resistance and they have unique mechanism of actions. Targeted therapies that are undergoing clinical trials include CAR-T cells, bi-specific antibodies, vaccines, ubiquitin ligase inhibitors and BCL-2 inhibitors. This book will help to develop an understanding of targeted therapies in Multiple Myeloma. Its goal is to provide a unique review of the mechanism of action and resistance of the many targeted therapies in Multiple Myeloma by leaders of the field. The book will be useful for students in medical science, clinicians, health professionals, scientists, pharmaceutical professionals, drug developers, and policy makers. This book will provide an insightful knowledge of the biology of Multiple Myeloma, the mechanism of action and resistance of targeted therapies, application of biomarkers and genomics and possible strategies in overcoming resistance and future development.
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