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Behavioral clinical trials for chron...

Freedland, Kenneth E.

Behavioral clinical trials for chronic diseasesscientific foundations /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Behavioral clinical trials for chronic diseasesby Lynda H. Powell, Kenneth E. Freedland, Peter G. Kaufmann.
Reminder of title:	scientific foundations /
Author:	Powell, Lynda H.
other author:	Freedland, Kenneth E.
Published:	Cham :Springer International Publishing :2021.
Description:	xviii, 314 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
Subject:	Chronic diseasesTreatment
Online resource:	https://doi.org/10.1007/978-3-030-39330-4
ISBN:	9783030393304$q(electronic bk.)

Behavioral clinical trials for chronic diseasesscientific foundations /
Powell, Lynda H.

Behavioral clinical trials for chronic diseasesscientific foundations /[electronic resource] :by Lynda H. Powell, Kenneth E. Freedland, Peter G. Kaufmann. - Cham :Springer International Publishing :2021. - xviii, 314 p. :ill., digital ;24 cm.

Introduction: the window of opportunity -- A selected history of randomized behavioral clinical trials: what we learned -- A clinically significant problem and a clincially significant benefit -- The process of developing a behavioral treatment for chronic disease -- The hypothesized pathway from behavioral treatment to chronic disease -- Equipoise, blinding, and investigator discipline -- Sensitivity to diversity -- Protection of randomization -- Choice of appropriate control group -- Readiness to conduct a behavioral randomized clinical trial -- Concluding remarks.

This is the first comprehensive guide to the design of behavioral randomized clinical trials (RCT) for chronic diseases. It includes the scientific foundations for behavioral trial methods, problems that have been encountered in past behavioral trials, advances in design that have evolved, and promising trends and opportunities for the future. The value of this book lies in its potential to foster an ability to "speak the language of medicine" through the conduct of high-quality behavioral clinical trials that match the rigor commonly seen in double-blind drug trials. It is relevant for testing any treatment aimed at improving a behavioral, social, psychosocial, environmental, or policy-level risk factor for a chronic disease including, for example, obesity, sedentary behavior, adherence to treatment, psychosocial stress, food deserts, and fragmented care. Outcomes of interest are those that are of clinical significance in the treatment of chronic diseases, including standard risk factors such as cholesterol, blood pressure, and glucose, and clinical outcomes such as hospitalizations, functional limitations, excess morbidity, quality of life, and mortality. This link between behavior and chronic disease requires innovative clinical trial methods not only from the behavioral sciences but also from medicine, epidemiology, and biostatistics. This integration does not exist in any current book, or in any training program, in either the behavioral sciences or medicine.

ISBN: 9783030393304$q(electronic bk.)

Standard No.: 10.1007/978-3-030-39330-4doiSubjects--Topical Terms:

908328
Chronic diseases
--Treatment

LC Class. No.: RC108 / .P68 2021

Dewey Class. No.: 616.044

Behavioral clinical trials for chronic diseasesscientific foundations /
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505 0 $a Introduction: the window of opportunity -- A selected history of randomized behavioral clinical trials: what we learned -- A clinically significant problem and a clincially significant benefit -- The process of developing a behavioral treatment for chronic disease -- The hypothesized pathway from behavioral treatment to chronic disease -- Equipoise, blinding, and investigator discipline -- Sensitivity to diversity -- Protection of randomization -- Choice of appropriate control group -- Readiness to conduct a behavioral randomized clinical trial -- Concluding remarks.
520 $a This is the first comprehensive guide to the design of behavioral randomized clinical trials (RCT) for chronic diseases. It includes the scientific foundations for behavioral trial methods, problems that have been encountered in past behavioral trials, advances in design that have evolved, and promising trends and opportunities for the future. The value of this book lies in its potential to foster an ability to "speak the language of medicine" through the conduct of high-quality behavioral clinical trials that match the rigor commonly seen in double-blind drug trials. It is relevant for testing any treatment aimed at improving a behavioral, social, psychosocial, environmental, or policy-level risk factor for a chronic disease including, for example, obesity, sedentary behavior, adherence to treatment, psychosocial stress, food deserts, and fragmented care. Outcomes of interest are those that are of clinical significance in the treatment of chronic diseases, including standard risk factors such as cholesterol, blood pressure, and glucose, and clinical outcomes such as hospitalizations, functional limitations, excess morbidity, quality of life, and mortality. This link between behavior and chronic disease requires innovative clinical trial methods not only from the behavioral sciences but also from medicine, epidemiology, and biostatistics. This integration does not exist in any current book, or in any training program, in either the behavioral sciences or medicine.
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