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SARS-CoV-2 spike protein convergent ...

Focosi, Daniele.

SARS-CoV-2 spike protein convergent evolutionimpact of virus variants on efficacy of COVID-19 therapeutics and vaccines /

Record Type:	Electronic resources : Monograph/item
Title/Author:	SARS-CoV-2 spike protein convergent evolutionby Daniele Focosi.
Reminder of title:	impact of virus variants on efficacy of COVID-19 therapeutics and vaccines /
Author:	Focosi, Daniele.
Published:	Cham :Springer International Publishing :2021.
Description:	xiii, 136 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
Subject:	COVID-19 (Disease)
Online resource:	https://doi.org/10.1007/978-3-030-87324-0
ISBN:	9783030873240$q(electronic bk.)

SARS-CoV-2 spike protein convergent evolutionimpact of virus variants on efficacy of COVID-19 therapeutics and vaccines /
Focosi, Daniele.

SARS-CoV-2 spike protein convergent evolutionimpact of virus variants on efficacy of COVID-19 therapeutics and vaccines /[electronic resource] :by Daniele Focosi. - Cham :Springer International Publishing :2021. - xiii, 136 p. :ill., digital ;24 cm. - SpringerBriefs in microbiology,2191-5393. - SpringerBriefs in microbiology..

Chapter 1. Why the Spike protein is relevant for COVID19 therapeutics -- Chapter 2. SARS-CoV-2 variants -- Chapter 3. Conclusion.

This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.

ISBN: 9783030873240$q(electronic bk.)

Standard No.: 10.1007/978-3-030-87324-0doiSubjects--Topical Terms:

877725
COVID-19 (Disease)

LC Class. No.: RA644.C67

Dewey Class. No.: 614.592414

National Library of Medicine Call No.: QW 168.5.C8

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