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Tumor suppressor Par-4role in cancer...

Rangnekar, Vivek M.

Tumor suppressor Par-4role in cancer and other diseases /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Tumor suppressor Par-4edited by Vivek M. Rangnekar.
Reminder of title:	role in cancer and other diseases /
other author:	Rangnekar, Vivek M.
Published:	Cham :Springer International Publishing :2021.
Description:	x, 331 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
Subject:	Tumor suppressor proteins.
Online resource:	https://doi.org/10.1007/978-3-030-80558-6
ISBN:	9783030805586$q(electronic bk.)

Tumor suppressor Par-4role in cancer and other diseases /
Tumor suppressor Par-4role in cancer and other diseases /[electronic resource] :edited by Vivek M. Rangnekar. - Cham :Springer International Publishing :2021. - x, 331 p. :ill., digital ;24 cm.

Par-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimer's and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials. This second, companion volume will provide a comprehensive overview of Par-4's role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4.

ISBN: 9783030805586$q(electronic bk.)

Standard No.: 10.1007/978-3-030-80558-6doiSubjects--Topical Terms:

489173
Tumor suppressor proteins.

LC Class. No.: QR188.6

Dewey Class. No.: 612.01575

National Library of Medicine Call No.: QZ 202

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520 $a Par-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimer's and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials. This second, companion volume will provide a comprehensive overview of Par-4's role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4.
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