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Ophthalmic product developmentfrom b...

Kompella, Uday B.

Ophthalmic product developmentfrom bench to bedside /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Ophthalmic product developmentedited by Seshadri Neervannan, Uday B. Kompella.
Reminder of title:	from bench to bedside /
other author:	Neervannan, Seshadri.
Published:	Cham :Springer International Publishing :2021.
Description:	1 online resource (ix, 650 p.) :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
Subject:	Ophthalmic drugs.
Online resource:	https://doi.org/10.1007/978-3-030-76367-1
ISBN:	9783030763671$q(electronic bk.)

Ophthalmic product developmentfrom bench to bedside /
Ophthalmic product developmentfrom bench to bedside /[electronic resource] :edited by Seshadri Neervannan, Uday B. Kompella. - Cham :Springer International Publishing :2021. - 1 online resource (ix, 650 p.) :ill., digital ;24 cm. - AAPS advances in the pharmaceutical sciences series,372210-738X ;. - AAPS advances in the pharmaceutical sciences series ;3..

Introduction and History of Ophthalmic Product Development -- Ocular Surface Anatomy and Physiology: Impact on Product Development -- Anatomy and Physiology of the Anterior Chamber - Impact on Product Development -- Back of the eye anatomy & physiology - Impact on product development -- Physicochemical and Biological Fundamentals for Drug Delivery to the Eye -- Topical Ophthalmic Dosage Form Development - Key Components and Critical Quality Attributes -- Intra-ocular Injectable Dosage Form Development -- Microbiological Considerations for Ophthalmic Products - Sterility, Endotoxin Limits and Preservatives -- Packaging Development - Multi-dose container closure for preservative free products, extractable/leachables from packaging, new technologies -- Liquid ophthalmic drug products - physicochemical properties, formulations and manufacturing considerations -- Emulsions for topical eye delivery: state of the art and future perspectives -- Emulsions for topical eye delivery: state of the art and future perspectives -- Microparticle Products For The Eye - preformulation, formulation, and manufacturing considerations -- NANOPARTICLE PRODUCTS FOR THE EYE: preformulation, formulation and manufacturing considerations -- Advanced Hydrogel Formulations for the Eye -- Ophthalmic Product Development for Biologics -- Implantable Devices to Treat Ophthalmic Conditions -Drug Delivery Systems -- Development of Artificial Tears Products for Ocular Conditions -- Approval of Topical Ophthalmic Generic Products in the US - Simple to Complex Dosage Forms and Establishing Equivalency -- The development and commercialization of sustained-release ocular drug delivery technologies -- Manufacturing considerations and challenges for AAV Ocular Gene Therapy -- Transcorneal Kinetics of Topical Drugs and Nanoparticles.

This is a comprehensive textbook addressing the unique aspects of drug development for ophthalmic use. Beginning with a perspective on anatomy and physiology of the eye, the book provides a critical appraisal of principles that underlie ocular drug product development. The coverage encompasses topical and intraocular formulations, small molecules and biologics (including protein and gene therapies), conventional formulations (including solutions, suspensions, and emulsions), novel formulations (including nanoparticles, microparticles, and hydrogels), devices, and specialty products. Critical elements such as pharmacokinetics, influence of formulation technologies and ingredients, as well as impact of disease conditions on products development are addressed. Products intended for both the front and the back of the eye are discussed with an eye towards future advances.

ISBN: 9783030763671$q(electronic bk.)

Standard No.: 10.1007/978-3-030-76367-1doiSubjects--Topical Terms:

302561
Ophthalmic drugs.

LC Class. No.: RE994

Dewey Class. No.: 615.19

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245 0 0 $a Ophthalmic product development $h [electronic resource] : $b from bench to bedside / $c edited by Seshadri Neervannan, Uday B. Kompella.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2021.
300 $a 1 online resource (ix, 650 p.) : $b ill., digital ; $c 24 cm.
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505 0 $a Introduction and History of Ophthalmic Product Development -- Ocular Surface Anatomy and Physiology: Impact on Product Development -- Anatomy and Physiology of the Anterior Chamber - Impact on Product Development -- Back of the eye anatomy & physiology - Impact on product development -- Physicochemical and Biological Fundamentals for Drug Delivery to the Eye -- Topical Ophthalmic Dosage Form Development - Key Components and Critical Quality Attributes -- Intra-ocular Injectable Dosage Form Development -- Microbiological Considerations for Ophthalmic Products - Sterility, Endotoxin Limits and Preservatives -- Packaging Development - Multi-dose container closure for preservative free products, extractable/leachables from packaging, new technologies -- Liquid ophthalmic drug products - physicochemical properties, formulations and manufacturing considerations -- Emulsions for topical eye delivery: state of the art and future perspectives -- Emulsions for topical eye delivery: state of the art and future perspectives -- Microparticle Products For The Eye - preformulation, formulation, and manufacturing considerations -- NANOPARTICLE PRODUCTS FOR THE EYE: preformulation, formulation and manufacturing considerations -- Advanced Hydrogel Formulations for the Eye -- Ophthalmic Product Development for Biologics -- Implantable Devices to Treat Ophthalmic Conditions -Drug Delivery Systems -- Development of Artificial Tears Products for Ocular Conditions -- Approval of Topical Ophthalmic Generic Products in the US - Simple to Complex Dosage Forms and Establishing Equivalency -- The development and commercialization of sustained-release ocular drug delivery technologies -- Manufacturing considerations and challenges for AAV Ocular Gene Therapy -- Transcorneal Kinetics of Topical Drugs and Nanoparticles.
520 $a This is a comprehensive textbook addressing the unique aspects of drug development for ophthalmic use. Beginning with a perspective on anatomy and physiology of the eye, the book provides a critical appraisal of principles that underlie ocular drug product development. The coverage encompasses topical and intraocular formulations, small molecules and biologics (including protein and gene therapies), conventional formulations (including solutions, suspensions, and emulsions), novel formulations (including nanoparticles, microparticles, and hydrogels), devices, and specialty products. Critical elements such as pharmacokinetics, influence of formulation technologies and ingredients, as well as impact of disease conditions on products development are addressed. Products intended for both the front and the back of the eye are discussed with an eye towards future advances.
650 0 $a Ophthalmic drugs. $3 302561
650 0 $a Ocular pharmacology. $3 502778
650 1 4 $a Pharmaceutics. $3 913065
650 2 4 $a Ophthalmology. $3 274149
650 2 4 $a Drug Delivery. $3 911847
650 2 4 $a Structure-Based Drug Design. $3 913066
700 1 $a Neervannan, Seshadri. $3 913064
700 1 $a Kompella, Uday B. $3 288558
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer Nature eBook
830 0 $a AAPS advances in the pharmaceutical sciences series ; $v 3. $3 559046
856 4 0 $u https://doi.org/10.1007/978-3-030-76367-1
950 $a Biomedical and Life Sciences (SpringerNature-11642)