國立高雄大學圖資館 |

登入

回首頁

Metabolic Adaptations to Aerobic Exercise Training in Aging Mice.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Metabolic Adaptations to Aerobic Exercise Training in Aging Mice.
作者:	Marx, Tyler.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, 2021
面頁冊數:	66 p.
附註:	Source: Masters Abstracts International, Volume: 83-03.
附註:	Advisor: Stern, Jennifer.
Contained By:	Masters Abstracts International83-03.
標題:	Endocrinology.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28719576
ISBN:	9798538155651

Metabolic Adaptations to Aerobic Exercise Training in Aging Mice.
Marx, Tyler.

Metabolic Adaptations to Aerobic Exercise Training in Aging Mice. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 66 p.

Source: Masters Abstracts International, Volume: 83-03.

Thesis (M.S.)--The University of Arizona, 2021.

This item must not be sold to any third party vendors.

Exercise training is a lifestyle intervention proposed to treat age-related chronic diseases, such as obesity or Type 2 Diabetes. However, the type and intensity of exercise is difficult to predict in humans of advanced age, rendering exercise treatment as a less than ideal option. The purpose of this study was to gain an understanding of the metabolic effects resulting from initiating exercise training late in life in the mouse. We used 12 weeks of voluntary wheel running as an exercise intervention to test our hypothesis that initiating exercise training later in the life of a mouse improves metabolic function. We found that, although aged mice exercise on the voluntary running wheel significantly less than young mice, there are still notable exercise-induced metabolic improvements in aged mice. Exercise training decreases glucose stimulated insulin secretion and hypoglycemia stimulated glucagon secretion in aged mice. In aged, exercise trained mice, resting respiratory quotient is decreased compared to both young and aged sedentary mice indicating a greater shift towards fat oxidation. Paradoxically, only young exercise trained mice have a decrease in hepatic lipid content compared to age matched sedentary mice. Despite these metabolic adaptations, aged exercise trained mice are resistant to the exercise induced increase in energy expenditure (EE) observed in young mice. Initiating exercise training late in life produces some but not all metabolic improvements seen in young mice.

ISBN: 9798538155651Subjects--Topical Terms:

196517
Endocrinology.
Subjects--Index Terms:

Body Composition

Metabolic Adaptations to Aerobic Exercise Training in Aging Mice.
LDR:02671nmm a2200397 4500 001 616469
005 20220513114345.5
008 220920s2021 ||||||||||||||||| ||eng d
020 $a 9798538155651
035 $a (MiAaPQ)AAI28719576
035 $a AAI28719576
040 $a MiAaPQ $c MiAaPQ
100 1 $a Marx, Tyler. $3 915806
245 1 0 $a Metabolic Adaptations to Aerobic Exercise Training in Aging Mice.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2021
300 $a 66 p.
500 $a Source: Masters Abstracts International, Volume: 83-03.
500 $a Advisor: Stern, Jennifer.
502 $a Thesis (M.S.)--The University of Arizona, 2021.
506 $a This item must not be sold to any third party vendors.
520 $a Exercise training is a lifestyle intervention proposed to treat age-related chronic diseases, such as obesity or Type 2 Diabetes. However, the type and intensity of exercise is difficult to predict in humans of advanced age, rendering exercise treatment as a less than ideal option. The purpose of this study was to gain an understanding of the metabolic effects resulting from initiating exercise training late in life in the mouse. We used 12 weeks of voluntary wheel running as an exercise intervention to test our hypothesis that initiating exercise training later in the life of a mouse improves metabolic function. We found that, although aged mice exercise on the voluntary running wheel significantly less than young mice, there are still notable exercise-induced metabolic improvements in aged mice. Exercise training decreases glucose stimulated insulin secretion and hypoglycemia stimulated glucagon secretion in aged mice. In aged, exercise trained mice, resting respiratory quotient is decreased compared to both young and aged sedentary mice indicating a greater shift towards fat oxidation. Paradoxically, only young exercise trained mice have a decrease in hepatic lipid content compared to age matched sedentary mice. Despite these metabolic adaptations, aged exercise trained mice are resistant to the exercise induced increase in energy expenditure (EE) observed in young mice. Initiating exercise training late in life produces some but not all metabolic improvements seen in young mice.
590 $a School code: 0009.
650 4 $a Endocrinology. $3 196517
650 4 $a Physiology. $3 192980
650 4 $a Health sciences. $3 795394
650 4 $a Aging. $3 188869
650 4 $a Kinesiology. $3 203232
653 $a Body Composition
653 $a Energy Expenditure
653 $a Exercise
653 $a Metabolism
653 $a Voluntary Running Wheel
690 $a 0409
690 $a 0719
690 $a 0566
690 $a 0575
690 $a 0493
710 2 $a The University of Arizona. $b Physiological Sciences. $3 915807
773 0 $t Masters Abstracts International $g 83-03.
790 $a 0009
791 $a M.S.
792 $a 2021
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28719576