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Tuning autophagy-inducing activity and toxicity for lanthanide nanocrystals

Record Type:	Electronic resources : Monograph/item
Title/Author:	Tuning autophagy-inducing activity and toxicity for lanthanide nanocrystalsby Yunjiao Zhang.
Author:	Zhang, Yunjiao.
Published:	Singapore :Springer Singapore :2022.
Description:	xv, 156 p. :ill. (chiefly col.), digital ;24 cm.
Notes:	"Doctoral thesis accepted by University of Science and Technology of China, Hefei, China."
Contained By:	Springer Nature eBook
Subject:	Nanocrystals.
Online resource:	https://doi.org/10.1007/978-981-16-8166-0
ISBN:	9789811681660$q(electronic bk.)

Tuning autophagy-inducing activity and toxicity for lanthanide nanocrystals
Zhang, Yunjiao.

Tuning autophagy-inducing activity and toxicity for lanthanide nanocrystals[electronic resource] /by Yunjiao Zhang. - Singapore :Springer Singapore :2022. - xv, 156 p. :ill. (chiefly col.), digital ;24 cm. - Springer theses,2190-5061. - Springer theses..

"Doctoral thesis accepted by University of Science and Technology of China, Hefei, China."

Introduction -- Phage display identifies a specific high-affinity binding peptide RE-1 for lanthanide (LN) nanomaterials -- RE-1 forms a stable coating layer on the surface of upconversion nanoparticles / nanocrystals (UCN) -- Reduction of UCN sedimentation and nanomaterial-cell interaction by RE-1 coating -- RE-1 coating abrogates autophagy induction and toxicity for UCN in vitro and in vivo -- Enhancement of cell interaction and autophagy induction by coating with RE-1-RGD -- Conclusion and prospect.

This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.

ISBN: 9789811681660$q(electronic bk.)

Standard No.: 10.1007/978-981-16-8166-0doiSubjects--Topical Terms:

246150
Nanocrystals.

LC Class. No.: TA418.9.N35 / Z53 2022

Dewey Class. No.: 620.115

Tuning autophagy-inducing activity and toxicity for lanthanide nanocrystals
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505 0 $a Introduction -- Phage display identifies a specific high-affinity binding peptide RE-1 for lanthanide (LN) nanomaterials -- RE-1 forms a stable coating layer on the surface of upconversion nanoparticles / nanocrystals (UCN) -- Reduction of UCN sedimentation and nanomaterial-cell interaction by RE-1 coating -- RE-1 coating abrogates autophagy induction and toxicity for UCN in vitro and in vivo -- Enhancement of cell interaction and autophagy induction by coating with RE-1-RGD -- Conclusion and prospect.
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