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Gadd45 stress sensor genes

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Gadd45 stress sensor genesedited by M. Raza Zaidi, Dan A. Liebermann.
其他作者:	Zaidi, M. Raza.
出版者:	Cham :Springer International Publishing :2022.
面頁冊數:	ix, 153 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
標題:	Human molecular genetics.
電子資源:	https://doi.org/10.1007/978-3-030-94804-7
ISBN:	9783030948047$q(electronic bk.)

Gadd45 stress sensor genes
Gadd45 stress sensor genes[electronic resource] /edited by M. Raza Zaidi, Dan A. Liebermann. - Second edition. - Cham :Springer International Publishing :2022. - ix, 153 p. :ill., digital ;24 cm. - Advances in experimental medicine and biology,v. 13602214-8019 ;. - Advances in experimental medicine and biology ;946..

GADD45 in Stress Signaling, Cell Cycle Control, and Apoptosis -- GADD45 in Development and Cancer -- GADD45 in Normal Hematopoiesis and Leukemia -- GADD45 in DNA Methylation and DNA Repair -- GADD45 Proteins in Immunity -- GADD45 in Liver Function and Cancer -- GADD45 in Pre-Eclampsia -- GADD45 in Senescence -- GADD45 in Neuronal Development, Function, and Injury -- Index.

This second edition is fully updated throughout and covers the emerging evidence that indicates that the Gadd45 family of proteins plays a unique and critical role as sensors of stress, including genotoxic, physiological, and oncogenic stress. It sheds light on the complex cellular stress response, encompassing myriad molecular pathways with a plethora of regulators and effectors. The GADD45 stress response genes encode small (18 kd) nuclear/cytoplasmic proteins. These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. Despite marked similarities, Gadd45 genes are regulated differentially and exhibit functional diversity. Gadd45 proteins respond to physiological and oncogenic stress, and are implicated in cell cycle arrest, DNA demethylation and repair, apoptosis, cell survival, genomic stability, and inflammation. The purpose of this book is to provide a comprehensive overview of the unique global role that Gadd45 proteins play as stress sensors and the molecular pathways involved.

ISBN: 9783030948047$q(electronic bk.)

Standard No.: 10.1007/978-3-030-94804-7doiSubjects--Topical Terms:

188612
Human molecular genetics.

LC Class. No.: QH431

Dewey Class. No.: 11.01816

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520 $a This second edition is fully updated throughout and covers the emerging evidence that indicates that the Gadd45 family of proteins plays a unique and critical role as sensors of stress, including genotoxic, physiological, and oncogenic stress. It sheds light on the complex cellular stress response, encompassing myriad molecular pathways with a plethora of regulators and effectors. The GADD45 stress response genes encode small (18 kd) nuclear/cytoplasmic proteins. These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. Despite marked similarities, Gadd45 genes are regulated differentially and exhibit functional diversity. Gadd45 proteins respond to physiological and oncogenic stress, and are implicated in cell cycle arrest, DNA demethylation and repair, apoptosis, cell survival, genomic stability, and inflammation. The purpose of this book is to provide a comprehensive overview of the unique global role that Gadd45 proteins play as stress sensors and the molecular pathways involved.
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