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Handbook of the biology of aging

Record Type:	Electronic resources : Monograph/item
Title/Author:	Handbook of the biology of agingedited by Nicolas Musi, Peter J. Hornsby.
remainder title:	Biology of aging
other author:	Musi, Nicolas.
Published:	Amsterdam :Academic Press,2021.
Description:	1 online resource.
Subject:	AgingCongresses.Physiological aspects
Online resource:	https://www.sciencedirect.com/science/book/9780128159620
ISBN:	9780128162835 (electronic bk.)

Handbook of the biology of aging
Handbook of the biology of aging[electronic resource] /Biology of agingedited by Nicolas Musi, Peter J. Hornsby. - 9th ed. - Amsterdam :Academic Press,2021. - 1 online resource. - The handbooks of aging. - Handbooks of aging..

Includes bibliographical references and index.

Front Cover -- Handbook of the Biology of Aging -- Copyright Page -- Dedication -- References -- Contents -- List of contributors -- About the editors -- Foreword -- Preface -- I. Basic mechanisms, underlying physiological changes, model organisms and interventions -- 1 Longevity as a complex genetic trait -- Introduction -- Defining the aging gene-space -- Direct screens for genetic longevity determinants -- RNA interference screens in nematodes -- Knockout screens in budding yeast -- Overexpression and knockout screens in fruit flies -- Leveraging genetic diversity to identify aging loci.

ISBN: 9780128162835 (electronic bk.)Subjects--Topical Terms:

439921
Aging
--Physiological aspects--Congresses.Index Terms--Genre/Form:

214472
Electronic books.

LC Class. No.: QP86

Dewey Class. No.: 612.67

Handbook of the biology of aging
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245 0 0 $a Handbook of the biology of aging $h [electronic resource] / $c edited by Nicolas Musi, Peter J. Hornsby.
246 3 0 $a Biology of aging
250 $a 9th ed.
260 $a Amsterdam : $b Academic Press, $c 2021.
300 $a 1 online resource.
490 1 $a The handbooks of aging
504 $a Includes bibliographical references and index.
505 0 $a Front Cover -- Handbook of the Biology of Aging -- Copyright Page -- Dedication -- References -- Contents -- List of contributors -- About the editors -- Foreword -- Preface -- I. Basic mechanisms, underlying physiological changes, model organisms and interventions -- 1 Longevity as a complex genetic trait -- Introduction -- Defining the aging gene-space -- Direct screens for genetic longevity determinants -- RNA interference screens in nematodes -- Knockout screens in budding yeast -- Overexpression and knockout screens in fruit flies -- Leveraging genetic diversity to identify aging loci.
505 8 $a Mapping longevity genes in human populations -- Mapping longevity genes in mouse populations -- Mouse-human concordance -- Age-associated gene expression studies -- Nongenetic sources of complexity -- Tissue-specific aging -- Tissue-specific age-related DNA methylation -- Tissue-specific responses of aging pathways -- Gene-environment interaction -- Genetic response to dietary restriction -- Dietary restriction: quantity, composition, and timing -- Other environmental factors that influence aging -- Emerging tools for studying complex genetic traits.
505 8 $a High-throughput life span assays in yeast and worms -- Genome-scale mouse knockout collection -- Collaborative cross and diversity outbred mice -- Expression QTLs -- Aging biomarkers -- Conclusions -- References -- 2 DNA damage and repair in aging -- Introduction -- Overview of the DNA damage response -- Endogenous DNA damage -- DNA damage induced by environmental exposures -- Linkage of DNA repair mechanisms to aging -- Nucleotide excision repair -- Base excision repair -- DNA double-strand break repair -- DNA damage theory of aging -- Aging disorders associated with DNA damage.
505 8 $a Diseases stemming from mutations in RecQ helicases -- Werner syndrome -- RECQL4 and premature aging syndromes -- Progeroid and other disorders associated with defects in nucleotide excision repair -- Xeroderma pigmentosum -- Cockayne syndrome -- Trichothiodystrophy -- XFE progeroid syndrome -- MDPL syndrome -- Ruijs-Aalfs syndrome -- Conclusions and future perspectives -- Acknowledgments -- References -- 3 Mechanisms of cell senescence in aging -- What is senescence? Building blocks and feedback loops -- The building blocks of the senescent phenotype -- Telomeres and the DNA damage response.
505 8 $a Senescence-associated secretory phenotype -- Senescence-associated mitochondrial dysfunction -- Nutrient signaling -- Autophagy/mitophagy -- Epigenetic reprogramming -- Terminology -- Replicative versus stress-induced senescence -- Senescence-associated secretory phenotype -- Senescence during aging in vivo -- Senescence in postmitotic cells -- Senescent cell bystander effects -- Senolytics and senostatics as antiaging interventions -- Senolytics -- Senostatics -- Conclusions -- References -- 4 The nature of aging and the geroscience hypothesis -- Aging and the geroscience hypothesis.
650 0 $a Aging $x Physiological aspects $v Congresses. $3 439921
655 4 $a Electronic books. $2 local. $3 214472
700 1 $a Musi, Nicolas. $3 928535
700 1 $a Hornsby, Peter. $3 928536
830 0 $a Handbooks of aging. $3 537082
856 4 0 $u https://www.sciencedirect.com/science/book/9780128159620