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Nuclear receptors in human health and disease

Record Type:	Electronic resources : Monograph/item
Title/Author:	Nuclear receptors in human health and diseaseedited by Moray J. Campbell, Charlotte L. Bevan.
other author:	Campbell, Moray J.
Published:	Cham :Springer International Publishing :2022.
Description:	xii, 346 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
Subject:	Nuclear receptors (Biochemistry)
Online resource:	https://doi.org/10.1007/978-3-031-11836-4
ISBN:	9783031118364$q(electronic bk.)

Nuclear receptors in human health and disease
Nuclear receptors in human health and disease[electronic resource] /edited by Moray J. Campbell, Charlotte L. Bevan. - Cham :Springer International Publishing :2022. - xii, 346 p. :ill., digital ;24 cm. - Advances in experimental medicine and biology,v. 13902214-8019 ;. - Advances in experimental medicine and biology ;946..

This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.

ISBN: 9783031118364$q(electronic bk.)

Standard No.: 10.1007/978-3-031-11836-4doiSubjects--Topical Terms:

203275
Nuclear receptors (Biochemistry)

LC Class. No.: QH603.C43 / N83 2022

Dewey Class. No.: 572.845

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520 $a This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.
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