國立高雄大學圖資館 |

Language: English

Back

The medicinal chemistry of glucocorticoid receptor modulators

Record Type:	Electronic resources : Monograph/item
Title/Author:	The medicinal chemistry of glucocorticoid receptor modulatorsby Adrian Hobson.
Author:	Hobson, Adrian.
Published:	Cham :Springer Nature Switzerland :2023.
Description:	ix, 142 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
Subject:	GlucocorticoidsReceptors.
Online resource:	https://doi.org/10.1007/978-3-031-28732-9
ISBN:	9783031287329$q(electronic bk.)

The medicinal chemistry of glucocorticoid receptor modulators
Hobson, Adrian.

The medicinal chemistry of glucocorticoid receptor modulators[electronic resource] /by Adrian Hobson. - Cham :Springer Nature Switzerland :2023. - ix, 142 p. :ill., digital ;24 cm. - SpringerBriefs in molecular science,2191-5415. - SpringerBriefs in molecular science..

Introduction -- cortisol-based glucocorticoids -- metabolically inactivated glucocorticoids -- prodrugs -- selective glucocorticoid receptor modulators -- polymers and particles -- QSAR and Modelling -- Antibody Drug Conjugates -- Conclusion.

This book covers the design and development of glucocorticoid receptor modulators (GRM) from cortisol to antibody-drug conjugate payloads over the last 70 years. The author starts with an introduction to the background of glucocorticoid receptor modulators as potential therapeutic modalities. This is followed by seven chapters in which he collates and discusses the medicinal chemistry journey of GRMs, reviewing topics such as cortisol-based glucocorticoids, the different approaches that have been pursued to enable chronic dosing of GRM compounds by inactivation in plasma and the liver, the application of prodrugs to GRMs, selective GRMs, targeted delivery of GRMs using polymers and nanoparticles, and rational drug design approaches applied in the development of GRMs. Particular attention is given to the development of glucocorticoid receptor modulators as immunology antibody-drug conjugate payloads. In the book's final chapter, the author critiques the medicinal chemistry progress made since the discovery of cortisone and the promise of the latest antibody-drug conjugates that release a GRM payload. In this book, readers will also find an overview of the X-ray structures of glucocorticoid receptor antagonists and a list of all the earlier reviews that cover part of the medicinal chemistry story of GRM collated by keywords organized in a table. With several examples of crystal structures and molecular modeling, this book illustrates the huge effort by multiple companies and research groups to develop glucocorticoid receptor modulators. Professionals and scholars alike will find it a handy tool, and appreciate the latest research findings that it presents.

ISBN: 9783031287329$q(electronic bk.)

Standard No.: 10.1007/978-3-031-28732-9doiSubjects--Topical Terms:

949769
Glucocorticoids
--Receptors.

LC Class. No.: QP572.G54 / H63 2023

Dewey Class. No.: 612.405

The medicinal chemistry of glucocorticoid receptor modulators
LDR:03012nmm a2200349 a 4500 001 642426
003 DE-He213
005 20230411063455.0
006 m d
007 cr nn 008maaau
008 231123s2023 sz s 0 eng d
020 $a 9783031287329$q(electronic bk.)
020 $a 9783031287312$q(paper)
024 7 $a 10.1007/978-3-031-28732-9 $2 doi
035 $a 978-3-031-28732-9
040 $a GP $c GP
041 0 $a eng
050 4 $a QP572.G54 $b H63 2023
072 7 $a PNN $2 bicssc
072 7 $a PSB $2 bicssc
072 7 $a SCI013020 $2 bisacsh
072 7 $a PNB $2 thema
082 0 4 $a 612.405 $2 23
090 $a QP572.G54 $b H684 2023
100 1 $a Hobson, Adrian. $3 949768
245 1 4 $a The medicinal chemistry of glucocorticoid receptor modulators $h [electronic resource] / $c by Adrian Hobson.
260 $a Cham : $b Springer Nature Switzerland : $b Imprint: Springer, $c 2023.
300 $a ix, 142 p. : $b ill., digital ; $c 24 cm.
490 1 $a SpringerBriefs in molecular science, $x 2191-5415
505 0 $a Introduction -- cortisol-based glucocorticoids -- metabolically inactivated glucocorticoids -- prodrugs -- selective glucocorticoid receptor modulators -- polymers and particles -- QSAR and Modelling -- Antibody Drug Conjugates -- Conclusion.
520 $a This book covers the design and development of glucocorticoid receptor modulators (GRM) from cortisol to antibody-drug conjugate payloads over the last 70 years. The author starts with an introduction to the background of glucocorticoid receptor modulators as potential therapeutic modalities. This is followed by seven chapters in which he collates and discusses the medicinal chemistry journey of GRMs, reviewing topics such as cortisol-based glucocorticoids, the different approaches that have been pursued to enable chronic dosing of GRM compounds by inactivation in plasma and the liver, the application of prodrugs to GRMs, selective GRMs, targeted delivery of GRMs using polymers and nanoparticles, and rational drug design approaches applied in the development of GRMs. Particular attention is given to the development of glucocorticoid receptor modulators as immunology antibody-drug conjugate payloads. In the book's final chapter, the author critiques the medicinal chemistry progress made since the discovery of cortisone and the promise of the latest antibody-drug conjugates that release a GRM payload. In this book, readers will also find an overview of the X-ray structures of glucocorticoid receptor antagonists and a list of all the earlier reviews that cover part of the medicinal chemistry story of GRM collated by keywords organized in a table. With several examples of crystal structures and molecular modeling, this book illustrates the huge effort by multiple companies and research groups to develop glucocorticoid receptor modulators. Professionals and scholars alike will find it a handy tool, and appreciate the latest research findings that it presents.
650 0 $a Glucocorticoids $x Receptors. $3 949769
650 0 $a Pharmaceutical chemistry. $3 203135
650 1 4 $a Medicinal Chemistry. $3 275183
650 2 4 $a Pharmaceutics. $3 913065
650 2 4 $a Structure-Based Drug Design. $3 913066
650 2 4 $a Computational Chemistry. $3 924784
650 2 4 $a History of Chemistry. $3 744425
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer Nature eBook
830 0 $a SpringerBriefs in molecular science. $3 557983
856 4 0 $u https://doi.org/10.1007/978-3-031-28732-9
950 $a Chemistry and Materials Science (SpringerNature-11644)