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Medical cannabis and the effects of cannabinoids on fighting cancer, multiple sclerosis, epilepsy, Parkinson's, and other neurodegenerative diseases

Record Type:	Electronic resources : Monograph/item
Title/Author:	Medical cannabis and the effects of cannabinoids on fighting cancer, multiple sclerosis, epilepsy, Parkinson's, and other neurodegenerative diseasesRana R. Zeine and Brian W. Teasdale.
other author:	Zeine, Rana,
Published:	Hershey, Pennsylvania :IGI Global,2023.
Description:	1 online resource (406 p.)
Subject:	MarijuanaTherapeutic use.
Online resource:	http://services.igi-global.com/resolvedoi/resolve.aspx?doi=10.4018/978-1-6684-5652-1
ISBN:	9781668456538 (electronic bk.)

Medical cannabis and the effects of cannabinoids on fighting cancer, multiple sclerosis, epilepsy, Parkinson's, and other neurodegenerative diseases
Medical cannabis and the effects of cannabinoids on fighting cancer, multiple sclerosis, epilepsy, Parkinson's, and other neurodegenerative diseases[electronic resource] /Rana R. Zeine and Brian W. Teasdale. - Hershey, Pennsylvania :IGI Global,2023. - 1 online resource (406 p.)

Includes bibliographical references and index.

Chapter 1. Medicinal cannabis for Alzheimer's disease -- Chapter 2. Protective effects of cannabis in neuroinflammation-mediated Alzheimer's disease -- Chapter 3. Cannabinoid efficacy for developmental epileptic encephalopathy (DEE)intractable seizure control: a systematic review of the literature -- Chapter 4. Medical cannabis in the treatment of epilepsy -- Chapter 5. Anti-tumor effects of cannabinoids in brain, lung, breast, prostate, colorectal, and pancreatic cancers: a systematic review of the literature -- Chapter 6. Cannabinoid neurobiology and medical cannabis intervention for amyotrophic lateral sclerosis (ALS): understanding the molecular mechanisms of action -- Chapter 7. Role of cannabinoids in the regulation of amyotrophic lateral sclerosis (ALS) -- Chapter 8. Neurobiology of cannabinoids and medical cannabis in therapeutic intervention for multiple sclerosis: understanding the molecular mechanisms of action -- Chapter 9. Pros and cons of cannabinoids as a potential therapeutic target for treating Parkinson's disease: cannabinoid receptor-mediated mechanism of action -- Chapter 10. The uses of cannabinoids in medicine and their spectroscopic applications -- Chapter 11. Therapeutic advantages of cannabimimetic plants: can they substitute medical cannabis? -- Chapter 12. History and legislative changes governing medical cannabis in Indonesia -- Chapter 13. A case study on the integration of cannabis law enforcement in new jersey.

"Research into the efficacy of medical marijuana is currently at different stages for different types of diseases. The most advanced studies in humans provide moderate-quality evidence for moderate effects that benefit patients withParkinson Disease and Multiple Sclerosis. There is also low-quality evidence for mild-to-moderate effects that benefit patients with Epilepsy and Huntington Disease. The best success in reducing spasticity, relieving pain, decreasing bladder overactivity, reducing anxiety and improving quality of sleep was achieved using a 50:50 mixture of Cannabidiol (CBD):delta-9-THC. Reducing frequency and duration of seizures in children with intractable epilepsy is achieved using CBD alone. Future studies can hopefully improve the quality of evidence by including control groups, recruiting more participants, and following them up for longer periods of time. In the meanwhile, the cellular and molecular mechanisms responsible for alleviating these neurological symptoms in animals and humans are being investigated. Some of the anti-inflammatory and neuroprotective effects are mediated through one or both of the cannabinoid receptors CB1 and CB2 distributed on immune and neural cells, while some of the anti-epileptic effects are mediated through other receptors found in the central nervous system. Animal studies show that cannabinoids are effective anti-inflammatory and anti-tumor agents. In experimental xenograft models for brain cancer, lung, breast, colorectal, pancreatic and other cancers, treatment with either CBD alone or in mixtures with THC, significantly shrinks the tumors, inhibits tumor cell migration, slows metastasis, disrupts tumor blood vessel formation (angiogenesis), inhibits tumor cell proliferation and increases tumor cell death. Future studies are warranted to investigate these anti-tumor effects in human cancer patients, however, a small study onadozen brain cancer patients demonstrated a modest increase in overall survival, and a case study on a lung cancer patient who refused chemotherapy and used cannabinoids instead reported a remarkable regression of the lung cancer tumors. Research efforts are intensifying to elucidate the multitude of cell signaling mechanisms that might be involved in mediating these remarkable anti-cancer and anti-angiogenic effects. The implications are that the next decade will be the dawnof a new era of pharmacotherapeutic applications of medical marijuana treatments in oncology for all cancer types, neurology for all movement disorders, demyelinative and dementia-causing neurodegenerative diseases, rheumatology and gastroenterology for all autoimmune and inflammatory disorders, and palliative care medicine for anxiety and pain management. This publication will include 15 chapters by experts on the use of cannabinoids and medical marijuana in different typesofcancer and different types of neurologic or inflammatory diseases. Some authors will discuss the physiologic and biochemical mechanisms while others will report on clinical benefits and pharmacological challenges"--

ISBN: 9781668456538 (electronic bk.)Subjects--Topical Terms:

807474
Marijuana
--Therapeutic use.Index Terms--Genre/Form:

214472
Electronic books.

LC Class. No.: RM666.C266 / M43 2023e

Dewey Class. No.: 615.3/23648

National Library of Medicine Call No.: WB 925 / .M43 2023e

Medical cannabis and the effects of cannabinoids on fighting cancer, multiple sclerosis, epilepsy, Parkinson's, and other neurodegenerative diseases
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504 $a Includes bibliographical references and index.
505 0 $a Chapter 1. Medicinal cannabis for Alzheimer's disease -- Chapter 2. Protective effects of cannabis in neuroinflammation-mediated Alzheimer's disease -- Chapter 3. Cannabinoid efficacy for developmental epileptic encephalopathy (DEE)intractable seizure control: a systematic review of the literature -- Chapter 4. Medical cannabis in the treatment of epilepsy -- Chapter 5. Anti-tumor effects of cannabinoids in brain, lung, breast, prostate, colorectal, and pancreatic cancers: a systematic review of the literature -- Chapter 6. Cannabinoid neurobiology and medical cannabis intervention for amyotrophic lateral sclerosis (ALS): understanding the molecular mechanisms of action -- Chapter 7. Role of cannabinoids in the regulation of amyotrophic lateral sclerosis (ALS) -- Chapter 8. Neurobiology of cannabinoids and medical cannabis in therapeutic intervention for multiple sclerosis: understanding the molecular mechanisms of action -- Chapter 9. Pros and cons of cannabinoids as a potential therapeutic target for treating Parkinson's disease: cannabinoid receptor-mediated mechanism of action -- Chapter 10. The uses of cannabinoids in medicine and their spectroscopic applications -- Chapter 11. Therapeutic advantages of cannabimimetic plants: can they substitute medical cannabis? -- Chapter 12. History and legislative changes governing medical cannabis in Indonesia -- Chapter 13. A case study on the integration of cannabis law enforcement in new jersey.
520 $a "Research into the efficacy of medical marijuana is currently at different stages for different types of diseases. The most advanced studies in humans provide moderate-quality evidence for moderate effects that benefit patients withParkinson Disease and Multiple Sclerosis. There is also low-quality evidence for mild-to-moderate effects that benefit patients with Epilepsy and Huntington Disease. The best success in reducing spasticity, relieving pain, decreasing bladder overactivity, reducing anxiety and improving quality of sleep was achieved using a 50:50 mixture of Cannabidiol (CBD):delta-9-THC. Reducing frequency and duration of seizures in children with intractable epilepsy is achieved using CBD alone. Future studies can hopefully improve the quality of evidence by including control groups, recruiting more participants, and following them up for longer periods of time. In the meanwhile, the cellular and molecular mechanisms responsible for alleviating these neurological symptoms in animals and humans are being investigated. Some of the anti-inflammatory and neuroprotective effects are mediated through one or both of the cannabinoid receptors CB1 and CB2 distributed on immune and neural cells, while some of the anti-epileptic effects are mediated through other receptors found in the central nervous system. Animal studies show that cannabinoids are effective anti-inflammatory and anti-tumor agents. In experimental xenograft models for brain cancer, lung, breast, colorectal, pancreatic and other cancers, treatment with either CBD alone or in mixtures with THC, significantly shrinks the tumors, inhibits tumor cell migration, slows metastasis, disrupts tumor blood vessel formation (angiogenesis), inhibits tumor cell proliferation and increases tumor cell death. Future studies are warranted to investigate these anti-tumor effects in human cancer patients, however, a small study onadozen brain cancer patients demonstrated a modest increase in overall survival, and a case study on a lung cancer patient who refused chemotherapy and used cannabinoids instead reported a remarkable regression of the lung cancer tumors. Research efforts are intensifying to elucidate the multitude of cell signaling mechanisms that might be involved in mediating these remarkable anti-cancer and anti-angiogenic effects. The implications are that the next decade will be the dawnof a new era of pharmacotherapeutic applications of medical marijuana treatments in oncology for all cancer types, neurology for all movement disorders, demyelinative and dementia-causing neurodegenerative diseases, rheumatology and gastroenterology for all autoimmune and inflammatory disorders, and palliative care medicine for anxiety and pain management. This publication will include 15 chapters by experts on the use of cannabinoids and medical marijuana in different typesofcancer and different types of neurologic or inflammatory diseases. Some authors will discuss the physiologic and biochemical mechanisms while others will report on clinical benefits and pharmacological challenges"-- $c Provided by publisher.
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