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Biomarkers for Huntington's diseaseimproving clinical outcomes /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Biomarkers for Huntington's diseaseedited by Elizabeth A. Thomas, Georgia M. Parkin.
Reminder of title:	improving clinical outcomes /
other author:	Thomas, Elizabeth A.
Published:	Cham :Springer International Publishing :2023.
Description:	xvi, 475 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
Subject:	Huntington's diseaseDiagnosis.
Online resource:	https://doi.org/10.1007/978-3-031-32815-2
ISBN:	9783031328152$q(electronic bk.)

Biomarkers for Huntington's diseaseimproving clinical outcomes /
Biomarkers for Huntington's diseaseimproving clinical outcomes /[electronic resource] :edited by Elizabeth A. Thomas, Georgia M. Parkin. - Cham :Springer International Publishing :2023. - xvi, 475 p. :ill., digital ;24 cm. - Contemporary clinical neuroscience,2627-5341. - Contemporary clinical neuroscience..

Huntington's disease (HD) is a fatal, inherited, neurodegenerative disorder, characterized by chorea, motor instabilities, psychiatric manifestations and cognitive decline. Early genetic testing provides an opportunity for clinical interventions aimed at delaying onset and/or slowing progression of disease; however, current treatments for HD are limited, with only two FDA-approved drugs available to manage chorea. Encouragingly, however, several disease-modifying treatment approaches are in the therapeutic pipeline, with more than 200 clinical studies, and many more preclinical studies, in the works. Robust and reliable biomarkers are needed to predict disease onset, monitor disease progression and assess treatment responses. More specifically, biomarkers to stratify patients for clinical trials and biomarkers to track drug efficacy will certainly lead to improved clinical trial design and success. This book represents the first book focused solely on biomarkers for HD and represents a distinct resource that will be informative, not only for clinicians and those involved in clinical trial design, but also for a wide range of neurodegenerative disease researchers. This edited volume is written by top leaders in the field, and takes a cross-disciplinary approach to cover a broad spectrum of biomarker types, in order to provide the latest advances in the development of biochemical, molecular, imaging and digital biomarkers that have been investigated for HD. With the ultimate goal of treating patients, the development of disease-associated biomarkers has never been more important.

ISBN: 9783031328152$q(electronic bk.)

Standard No.: 10.1007/978-3-031-32815-2doiSubjects--Topical Terms:

962104
Huntington's disease
--Diagnosis.

LC Class. No.: RC394.H85 / B56 2023

Dewey Class. No.: 616.851075

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490 1 $a Contemporary clinical neuroscience, $x 2627-5341
520 $a Huntington's disease (HD) is a fatal, inherited, neurodegenerative disorder, characterized by chorea, motor instabilities, psychiatric manifestations and cognitive decline. Early genetic testing provides an opportunity for clinical interventions aimed at delaying onset and/or slowing progression of disease; however, current treatments for HD are limited, with only two FDA-approved drugs available to manage chorea. Encouragingly, however, several disease-modifying treatment approaches are in the therapeutic pipeline, with more than 200 clinical studies, and many more preclinical studies, in the works. Robust and reliable biomarkers are needed to predict disease onset, monitor disease progression and assess treatment responses. More specifically, biomarkers to stratify patients for clinical trials and biomarkers to track drug efficacy will certainly lead to improved clinical trial design and success. This book represents the first book focused solely on biomarkers for HD and represents a distinct resource that will be informative, not only for clinicians and those involved in clinical trial design, but also for a wide range of neurodegenerative disease researchers. This edited volume is written by top leaders in the field, and takes a cross-disciplinary approach to cover a broad spectrum of biomarker types, in order to provide the latest advances in the development of biochemical, molecular, imaging and digital biomarkers that have been investigated for HD. With the ultimate goal of treating patients, the development of disease-associated biomarkers has never been more important.
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