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Metal-responsive base pair switching of ligand-type uracil nucleobases

Record Type:	Electronic resources : Monograph/item
Title/Author:	Metal-responsive base pair switching of ligand-type uracil nucleobasesby Keita Mori.
Author:	Mori, Keita.
Published:	Singapore :Springer Nature Singapore :2024.
Description:	xvii, 125 p. :ill. (some col.), digital ;24 cm.
Notes:	"Doctoral thesis accepted by The University of Tokyo, Tokyo, Japan."
Contained By:	Springer Nature eBook
Subject:	DNA-ligand interactions.
Online resource:	https://doi.org/10.1007/978-981-99-9400-7
ISBN:	9789819994007$q(electronic bk.)

Metal-responsive base pair switching of ligand-type uracil nucleobases
Mori, Keita.

Metal-responsive base pair switching of ligand-type uracil nucleobases[electronic resource] /by Keita Mori. - Singapore :Springer Nature Singapore :2024. - xvii, 125 p. :ill. (some col.), digital ;24 cm. - Springer theses,2190-5061. - Springer theses..

"Doctoral thesis accepted by The University of Tokyo, Tokyo, Japan."

1. General introduction -- 2. Metal-responsive DNA strand displacement reactions driven by base pair switching of 5-hydroxyuracil nucleobases -- 3. Metal-dependent base pair switching of N,N,-dicarboxymethyl-5-aminouracil nucleosides -- 4. Metal-responsive DNA tweezers driven by base pair switching of 5-hydroxyuracil nucleobases -- 5. Conclusion and perspectives.

In this thesis, the author proposes "metal-responsive base pair switching" of ligand-modified nucleobases as a novel tool for stimuli-responsive control of DNA assemblies. It is written to demonstrate broad applicability of the base pair switching in dynamic DNA nanotechnology and inspire researchers to use this technique. Based on specific interactions between ligand-type nucleobases and target metal ions, in this volume, DNA hybridization was dynamically controlled through strand displacement reactions. The base pair switching was further applied to develop metal-dependent DNA molecular machines. This novel strategy for stimuli-responsive regulation of DNA assemblies will greatly expand the scope of dynamic DNA nanotechnology. This volume uniquely features importance of elaborate molecular design based on chemistry for imparting stimuli responsiveness to DNA assemblies.

ISBN: 9789819994007$q(electronic bk.)

Standard No.: 10.1007/978-981-99-9400-7doiSubjects--Topical Terms:

200705
DNA-ligand interactions.

LC Class. No.: QP624.74

Dewey Class. No.: 572.86

Metal-responsive base pair switching of ligand-type uracil nucleobases
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505 0 $a 1. General introduction -- 2. Metal-responsive DNA strand displacement reactions driven by base pair switching of 5-hydroxyuracil nucleobases -- 3. Metal-dependent base pair switching of N,N,-dicarboxymethyl-5-aminouracil nucleosides -- 4. Metal-responsive DNA tweezers driven by base pair switching of 5-hydroxyuracil nucleobases -- 5. Conclusion and perspectives.
520 $a In this thesis, the author proposes "metal-responsive base pair switching" of ligand-modified nucleobases as a novel tool for stimuli-responsive control of DNA assemblies. It is written to demonstrate broad applicability of the base pair switching in dynamic DNA nanotechnology and inspire researchers to use this technique. Based on specific interactions between ligand-type nucleobases and target metal ions, in this volume, DNA hybridization was dynamically controlled through strand displacement reactions. The base pair switching was further applied to develop metal-dependent DNA molecular machines. This novel strategy for stimuli-responsive regulation of DNA assemblies will greatly expand the scope of dynamic DNA nanotechnology. This volume uniquely features importance of elaborate molecular design based on chemistry for imparting stimuli responsiveness to DNA assemblies.
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650 0 $a Uracil. $3 975004
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