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Epigenetic mechanisms in breast cancer therapy and resistance

Record Type:	Electronic resources : Monograph/item
Title/Author:	Epigenetic mechanisms in breast cancer therapy and resistanceedited by Sanchita Bhatnagar.
other author:	Bhatnagar, Sanchita.
Published:	Cham :Springer Nature Switzerland :2024.
Description:	v, 106 p. :ill. (chiefly color), digital ;24 cm.
Contained By:	Springer Nature eBook
Subject:	BreastCancer
Online resource:	https://doi.org/10.1007/978-3-031-66686-5
ISBN:	9783031666865$q(electronic bk.)

Epigenetic mechanisms in breast cancer therapy and resistance
Epigenetic mechanisms in breast cancer therapy and resistance[electronic resource] /edited by Sanchita Bhatnagar. - Cham :Springer Nature Switzerland :2024. - v, 106 p. :ill. (chiefly color), digital ;24 cm. - Advances in experimental medicine and biology,v. 14652214-8019 ;. - Advances in experimental medicine and biology ;946..

Chapter 1 - MDIG in breast cancer progression and metastasis -- Chapter 2 - Tumor Microenvironment and Epigenetic Implications in Breast Cancer Progression -- Chapter 3 - The Epigenetic Landscape of Breast Cancer, Metabolism, and Obesity -- Chapter 4 - Epigenetic Modulations by Microbiome in Breast Cancer -- Chapter 5 - Facilitates chromatin transcription in breast and other cancers -- Chapter 6 - Advances in epigenetic therapeutics for breast cancer -- Chapter 7 - Detection methods for epigenetic mechanisms in breast cancer.

Epigenetic mechanisms are essential for normal mammalian development and maintenance of gene expression patterns. Disruption of epigenetic processes can lead to altered transcriptional regulation, gene levels, and malignant cellular transformation. Global alterations of the epigenetic landscape are a hallmark of tumorigenesis and metastasis. Conventionally, cancer was thought to be a genetic disease, but recent advancement in the field identified an abundance of epigenetic abnormalities along with genetic alterations. The extensive reprogramming of epigenetic machinery in cancer includes DNA methylation, histone modifications, nucleosome positioning and non-coding RNAs, specifically microRNA expression. Additionally, the reversible nature of epigenetic aberrations has led to the emergence of the promising field of epigenetic therapy, and recent FDA approval of epigenetic drugs for cancer treatment. This book focuses on the epigenetic mechanisms in breast cancertherapy and resistance. It is organized into three sections, including epigenetic mechanisms in breast cancer, targeting epigenetic mechanisms for new therapies, and new and emerging methodologies to study epigenetic alterations in breast cancer. Chapters highlight various epigenetic regulations that prevent breast cancer growth and progression, as well as epigenetic alterations that contribute to breast cancer progression. This text is a useful methodology book for researchers and students interested in epigenetics in breast cancer and the fundamentals of cancer biology.

ISBN: 9783031666865$q(electronic bk.)

Standard No.: 10.1007/978-3-031-66686-5doiSubjects--Topical Terms:

357478
Breast
--Cancer

LC Class. No.: RC280.B8

Dewey Class. No.: 616.99449

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520 $a Epigenetic mechanisms are essential for normal mammalian development and maintenance of gene expression patterns. Disruption of epigenetic processes can lead to altered transcriptional regulation, gene levels, and malignant cellular transformation. Global alterations of the epigenetic landscape are a hallmark of tumorigenesis and metastasis. Conventionally, cancer was thought to be a genetic disease, but recent advancement in the field identified an abundance of epigenetic abnormalities along with genetic alterations. The extensive reprogramming of epigenetic machinery in cancer includes DNA methylation, histone modifications, nucleosome positioning and non-coding RNAs, specifically microRNA expression. Additionally, the reversible nature of epigenetic aberrations has led to the emergence of the promising field of epigenetic therapy, and recent FDA approval of epigenetic drugs for cancer treatment. This book focuses on the epigenetic mechanisms in breast cancertherapy and resistance. It is organized into three sections, including epigenetic mechanisms in breast cancer, targeting epigenetic mechanisms for new therapies, and new and emerging methodologies to study epigenetic alterations in breast cancer. Chapters highlight various epigenetic regulations that prevent breast cancer growth and progression, as well as epigenetic alterations that contribute to breast cancer progression. This text is a useful methodology book for researchers and students interested in epigenetics in breast cancer and the fundamentals of cancer biology.
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