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Textbook of diabetes

Record Type:	Electronic resources : Monograph/item
Title/Author:	Textbook of diabetesedited by Richard I. G. Holt and Allan Flyvbjerg.
other author:	Holt, Richard I. G.
Published:	Hoboken, NJ :Wiley-Blackwell,c2023.
Description:	1 online resource (xviii, 1208 p.) :ill. (chiefly col.), col. maps.
Subject:	Diabetes.
Online resource:	https://onlinelibrary.wiley.com/doi/book/10.1002/9781119697473
ISBN:	9781119697473$q(electronic bk.)

Textbook of diabetes
Textbook of diabetes[electronic resource] /edited by Richard I. G. Holt and Allan Flyvbjerg. - 6th ed. - Hoboken, NJ :Wiley-Blackwell,c2023. - 1 online resource (xviii, 1208 p.) :ill. (chiefly col.), col. maps.

Includes bibliographical references and index.

Cover -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Preface -- List of Abbreviations -- Part 1 Diabetes in its Historical and Social Context -- Chapter 1 The History of Diabetes Mellitus -- Ancient times -- Seventeenth and eighteenth centuries -- Nineteenth century -- Clinical diabetes in the nineteenth century -- Twentieth century -- Discovery of insulin -- The post-insulin era -- Causes and natural history of diabetes -- Chronic diabetic complications -- Physiology -- Management of diabetes -- Insulin -- Other anti-diabetes agents -- Glucose management and treatment targets -- Diabetes-related complications -- Diabetic ketoacidosis -- Diabetes in pregnancy -- Delivery of care for people with diabetes -- References -- Chapter 2 Classification and Diagnosis of Diabetes -- Definition -- Diagnosis and classification of diabetes -- Methods and criteria for diagnosing diabetes -- Diagnostic thresholds -- Number of abnormal tests required -- Further considerations of method of diagnosis -- Analytical considerations -- Classification of diabetes types -- Type 1 diabetes -- Type 2 diabetes -- Other specific types -- Gestational diabetes -- Conclusion -- References -- Chapter 3 The Global Burden of Diabetes -- Prevalence -- Type 1 diabetes -- Type 2 diabetes -- Sub-Saharan Africa -- Europe -- Middle East and North Africa -- North America and Caribbean -- South and Central America -- South-East Asia -- Western Pacific -- Gestational diabetes mellitus -- Incidence of type 2 diabetes -- Trends in diabetes-related complications -- Macrovascular complications -- Lower-extremity amputations -- Microvascular complications -- End-stage renal disease -- Retinopathy -- Neuropathy -- Acute complications -- Mortality -- Emerging complications -- Cancer -- Mental health disorders -- Cognitive impairment -- Disability -- Infections.

This comprehensive textbook, edited by Richard I.G. Holt and Allan Flyvbjerg, provides an in-depth exploration of diabetes, covering its historical and social context, pathogenesis, management, and treatment. It delves into the physiology of glucose metabolism, the genetics of diabetes, and the epidemiology of both Type 1 and Type 2 diabetes. The book also addresses various complications associated with diabetes, including microvascular and macrovascular complications, and provides detailed information on treatment options, including insulin and new technologies for glucose monitoring. Intended for healthcare professionals and researchers, this sixth edition aims to enhance understanding and management of diabetes, empowering those affected by the disease.

Mode of access: World Wide Web.

ISBN: 9781119697473$q(electronic bk.)Subjects--Topical Terms:

274215
Diabetes.

LC Class. No.: RC660 / .T49 2024

Dewey Class. No.: 616.462

National Library of Medicine Call No.: WK 810

Textbook of diabetes
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245 0 0 $a Textbook of diabetes $h [electronic resource] / $c edited by Richard I. G. Holt and Allan Flyvbjerg.
250 $a 6th ed.
260 $a Hoboken, NJ : $b Wiley-Blackwell, $c c2023.
300 $a 1 online resource (xviii, 1208 p.) : $b ill. (chiefly col.), col. maps.
504 $a Includes bibliographical references and index.
505 0 $a Cover -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Preface -- List of Abbreviations -- Part 1 Diabetes in its Historical and Social Context -- Chapter 1 The History of Diabetes Mellitus -- Ancient times -- Seventeenth and eighteenth centuries -- Nineteenth century -- Clinical diabetes in the nineteenth century -- Twentieth century -- Discovery of insulin -- The post-insulin era -- Causes and natural history of diabetes -- Chronic diabetic complications -- Physiology -- Management of diabetes -- Insulin -- Other anti-diabetes agents -- Glucose management and treatment targets -- Diabetes-related complications -- Diabetic ketoacidosis -- Diabetes in pregnancy -- Delivery of care for people with diabetes -- References -- Chapter 2 Classification and Diagnosis of Diabetes -- Definition -- Diagnosis and classification of diabetes -- Methods and criteria for diagnosing diabetes -- Diagnostic thresholds -- Number of abnormal tests required -- Further considerations of method of diagnosis -- Analytical considerations -- Classification of diabetes types -- Type 1 diabetes -- Type 2 diabetes -- Other specific types -- Gestational diabetes -- Conclusion -- References -- Chapter 3 The Global Burden of Diabetes -- Prevalence -- Type 1 diabetes -- Type 2 diabetes -- Sub-Saharan Africa -- Europe -- Middle East and North Africa -- North America and Caribbean -- South and Central America -- South-East Asia -- Western Pacific -- Gestational diabetes mellitus -- Incidence of type 2 diabetes -- Trends in diabetes-related complications -- Macrovascular complications -- Lower-extremity amputations -- Microvascular complications -- End-stage renal disease -- Retinopathy -- Neuropathy -- Acute complications -- Mortality -- Emerging complications -- Cancer -- Mental health disorders -- Cognitive impairment -- Disability -- Infections.
505 8 $a Economic costs of diabetes -- Socioeconomic costs of diabetes -- Gaps and future directions -- References -- Chapter 4 Epidemiology of Type 1 Diabetes -- Occurrence of type 1 diabetes by age, sex, place, and time -- Occurrence of type 1 diabetes by age -- Incidence by sex -- Incidence by country -- Trends in incidence over time -- Variation in incidence within countries including by ethnicity -- Seasonal variation in diagnosis of type 1 diabetes -- Familial clustering and twin studies -- Environmental risk factors for type 1 diabetes: clues from epidemiological studies -- Specific putative environmental factors -- Mortality -- Conclusion -- Acknowledgements -- References -- Chapter 5 Epidemiology of Type 2 Diabetes -- Risk factors for type 2 diabetes -- Emerging risk factors -- Sugar-sweetened beverages -- Decreased sleep -- Depression and treatment of depression -- Drug-induced metabolic changes -- Environmental toxins -- Low birth weight and fetal malnutrition -- Maternal obesity, maternal hyperglycaemia, and other factors in early development -- Methodological issues in the epidemiology of type 2 diabetes -- Effects of changes in the definition of diabetes -- Emerging data on the incidence of type 2 diabetes -- Regional and ethnic patterns of type 2 diabetes worldwide -- Africa -- North America -- Central and South America -- Europe -- South-East Asia -- Middle East -- Western Pacific region -- Impact of diabetes -- Mortality and morbidity -- Healthcare burden and economic costs -- Prevention of type 2 diabetes -- Remission of type 2 diabetes -- Conclusion -- References -- Part 2 Normal Physiology -- Chapter 6 Overview of Glucose Metabolism -- Pancreatic islets of langerhans -- Insulin -- Effect on glucose metabolism -- Effect on lipid metabolism -- Effect on protein metabolism -- Glucagon -- Liver -- Skeletal muscle and adipose tissue.
505 8 $a Gastrointestinal tract -- Incretin hormones -- Microbiome -- Brain -- Kidney -- Other hormones involved in glucose metabolism -- Catecholamines -- Corticosteroids -- Growth hormones and insulin-like growth factor I -- References -- Chapter 7 Islet Function and Insulin Secretion -- Islet structure and function -- Islet anatomy -- Intra-islet interactions -- Insulin biosynthesis and storage -- Regulation of insulin secretion -- Nutrient-induced insulin secretion -- Regulation of insulin secretion by non-nutrients -- Conclusions -- References -- Chapter 8 Glucagon in Islet and Metabolic Regulation -- Anatomy and development of cells -- Proglucagon gene transcription, translation, and peptide processing -- Regulation of -cell secretion -- Glucagon actions in the liver: glucose and lipid metabolism -- Glucagon actions in the liver: amino acid metabolism and the hepatic--cell axis -- Glucagon intra-islet communication and insulin secretion -- Effects of glucagon on energy intake and energy expenditure -- Production of glucagon-like peptide 1 by cells -- Abnormalities of glucagon secretion andaction in diabetes -- Pharmacology based on glucagon action -- References -- Chapter 9 Mechanism of Insulin Action -- Insulin -- Insulin receptor -- Extracellular domain of the insulin receptor -- Receptor tyrosine kinase -- Insulin signalling cascade -- IRS proteins couple the insulin receptor to the downstream signalling cascade -- Phosphatidylinositol 3-kinase AKT cascade -- Insulin-regulated glucose transport -- Heterologous regulation and insulin resistance -- Transcriptional control of IRS1 -- Transcriptional control of IRS2 -- miRNA-mediated post-transcriptional regulation -- Regulation of IRS signalling by Ser/Thr phosphorylation -- Regulation of IRS degradation -- Regulation by protein and lipid phosphatases.
505 8 $a Mouse genetics reveal tissue-integrated insulin signalling -- Systemic insulin receptor signalling cascade -- Hepatic insulin receptorFOXO1 signalling -- Insulin signalling and glucose homeostasis in skeletal muscle -- Adipose insulin signalling -- IRS2 as a gateway to -cell function -- References -- Chapter 10 Central Control of Glucose Homeostasis -- Evolutionary considerations -- Overview of brain control of glucose homeostasis in normal physiology -- Autonomic control of pancreatic islet function -- Circadian control of metabolism -- How does the brain sense physiological changes in blood glucose? -- Glucose sensing and brain control of energy balance -- Glucose transporters and brain glucose uptake -- Evidence supporting indirect blood glucose sensing by the brain -- Parallels to brain control of thermoregulation -- Integration of glucose homeostasis, energy homeostasis, and thermoregulation -- Brain responses to perceived glucose deficiency -- Hypothesis: reduced brain glucose sensing predisposes to hyperglycaemia in type 2 diabetes -- The transition from obesity to type 2 diabetes -- Roles of insulin-dependent and -independent glucose lowering by the brain -- Clinical evidence supporting altered brain blood glucose handling in individuals with diabetes -- Targeting the brain to restore normoglycaemia -- Current and future anti-diabetes drugs that target central pathways -- Conclusion -- References -- Chapter 11 Control of Body Weight: How and Why Do We Gain Weight Easier Than We Lose It? -- Body weight regulation -- Energy homeostasis: control of appetite and body weight -- Physiological regulators of body weight -- Gut hormones -- Hypothalamus and neurotransmitters -- Adipose tissue -- Intestinal microbiome -- Beyond homeostasis: hedonic pathways -- Metabolic alterations with weight gain -- Compensatory mechanisms in response to weight loss.
505 8 $a Weight loss maintenance insights from bariatric surgery -- Genetic factors -- Evolutionary perspectives -- Monogenic obesity -- Polygenic susceptibility to obesity -- Epigenetic factors -- Environmental and behavioural factors -- Circadian rhythms, sleep patterns, and obesity -- The effect of dietary composition -- Medications and toxins -- Weight stigma and adverse impact on biology -- Effects of societal factors and policy -- Conclusion -- References -- Part 3 Pathogenesis of Diabetes -- Chapter 12 The Genetics of Diabetes -- Increase in diabetes prevalence -- Diabetes spectrum -- Diabetes heterogeneity -- Heritability of type 1 diabetes and type 2 diabetes -- Genetic architecture of type 1 diabetes and type 2 diabetes -- Genetic loci for type 1 diabetes -- Linkage studies for type 2 diabetes -- Candidate genes for type 2 diabetes -- Genome-wide association studies identify common variants associated with type 2 diabetes -- Rare variants with stronger effects are often rare -- Protective variants -- Gene-gene and gene-environment interactions -- Parent-of-origin effects -- Epigenetics -- Non-coding RNAs - MicroRNAs and LincRNAs -- Difficulties in assigning functions to associated genes -- Genotype-based treatment -- Little common genetic basis for type 1 diabetes and type 2 diabetes -- A holistic view: systems genetics -- Conclusion -- References -- Chapter 13 Genetics of Obesity -- Evidence for the genetic contribution to obesity -- Finding the genes that regulate body weight -- Obesity with developmental delay -- Prader-Willi syndrome -- Albright hereditary osteodystrophy -- Ciliary disorders -- BDNF, TRKB, and SH2B1 deficiency -- Obesity without developmental delay -- Leptin and leptin receptor deficiency -- POMC and PCSK1 deficiency -- MC4R deficiency -- SIM1 deficiency -- Rare variants in multiple genes associated with obesity -- Conclusion.
520 $a This comprehensive textbook, edited by Richard I.G. Holt and Allan Flyvbjerg, provides an in-depth exploration of diabetes, covering its historical and social context, pathogenesis, management, and treatment. It delves into the physiology of glucose metabolism, the genetics of diabetes, and the epidemiology of both Type 1 and Type 2 diabetes. The book also addresses various complications associated with diabetes, including microvascular and macrovascular complications, and provides detailed information on treatment options, including insulin and new technologies for glucose monitoring. Intended for healthcare professionals and researchers, this sixth edition aims to enhance understanding and management of diabetes, empowering those affected by the disease.
538 $a Mode of access: World Wide Web.
588 $a Part of the metadata in this record was created by AI, based on the text of the resource.
650 0 $a Diabetes. $3 274215
650 0 $a Diabetes $x Treatment. $3 276740
700 1 $a Holt, Richard I. G. $3 725319
700 1 $a Flyvbjerg, Allan. $3 998129
856 4 0 $u https://onlinelibrary.wiley.com/doi/book/10.1002/9781119697473