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Causal Inference on Gene Expression Analysis /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Causal Inference on Gene Expression Analysis /Milleno Pan.
作者:	Pan, Milleno,
面頁冊數:	1 electronic resource (60 pages)
附註:	Source: Masters Abstracts International, Volume: 86-11.
附註:	Advisors: Tansey, Wesley Committee members: Krogh-Madsen, Trine; Reznik, Ed.
Contained By:	Masters Abstracts International86-11.
標題:	Computer science.
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31937675
ISBN:	9798314882092

Causal Inference on Gene Expression Analysis /
Pan, Milleno,

Causal Inference on Gene Expression Analysis /Milleno Pan. - 1 electronic resource (60 pages)

Source: Masters Abstracts International, Volume: 86-11.

Gene set enrichment analysis requires robust statistical methods to uncover causal drivers in high dimensional data. In this work, we present a comprehensive framework for conditional independence testing that addresses the challenge of controlling the false discovery rate in these experiments. Our approach uses an amortized testing framework based on latent factor models to efficiently test across features, and incorporates a graph based hierarchical structure to form feature subsets for graphical FDR control methods such as DAGGER. We demonstrate that our framework not only groups biologically relevant genes into meaningful clusters but also effectively detects key genes in drug dose responses. These findings suggest a promising alternative to traditional methods for identifying causal gene-drug relationships.

English

ISBN: 9798314882092Subjects--Topical Terms:

199325
Computer science.
Subjects--Index Terms:

Causal inference

Causal Inference on Gene Expression Analysis /
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