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DNA Display :In vitro evolution of combinatorial chemistry libraries.

Record Type:	Electronic resources : Monograph/item
Title/Author:	DNA Display :
Reminder of title:	In vitro evolution of combinatorial chemistry libraries.
Author:	Halpin, David Riggs.
Description:	122 p.
Notes:	Adviser: Pehr Harbury.
Notes:	Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1689.
Contained By:	Dissertation Abstracts International65-04B.
Subject:	Biology, Molecular.
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3128397
ISBN:	0496756591

DNA Display :In vitro evolution of combinatorial chemistry libraries.
Halpin, David Riggs.

DNA Display :In vitro evolution of combinatorial chemistry libraries.[electronic resource] - 122 p.

Adviser: Pehr Harbury.

Thesis (Ph.D.)--Stanford University, 2004.

Man has used evolution as a tool for centuries, the earliest example being the breeding of crops and animals. Within the past 15 years, techniques have emerged that enable the cell-free evolution of DNA, RNA, and protein macromolecules for various functions, ranging from binding specificity to catalytic activity.

ISBN: 0496756591Subjects--Topical Terms:

226919
Biology, Molecular.

DNA Display :In vitro evolution of combinatorial chemistry libraries.
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520 # $a Man has used evolution as a tool for centuries, the earliest example being the breeding of crops and animals. Within the past 15 years, techniques have emerged that enable the cell-free evolution of DNA, RNA, and protein macromolecules for various functions, ranging from binding specificity to catalytic activity.
520 # $a This thesis reports the design and implementation of DNA Display, a method for the evolution of small-molecule populations produced by synthetic organic chemistry. The technique imparts an artificial genetic code upon small molecules, enabling their reproduction and breeding. DNA Display was successfully used to evolve a library of one million non-natural peptides for binding to a protein target. The process is simple and inexpensive, making small-molecule discovery widely accessible.
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