國立高雄大學圖資館 |

Language: English

Back

Peptide-supported organometallic cat...

Alexopoulos, Andrew D.

Peptide-supported organometallic catalyst for dual transformations under ambient aqueous conditions.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Peptide-supported organometallic catalyst for dual transformations under ambient aqueous conditions.
Author:	Alexopoulos, Andrew D.
Published:	Ann Arbor : ProQuest Dissertations & Theses, 2016
Description:	60 p.
Notes:	Source: Masters Abstracts International, Volume: 56-01.
Notes:	Adviser: Katarzyna Slowinska.
Contained By:	Masters Abstracts International56-01(E).
Subject:	Chemistry.
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10147312
ISBN:	9781369025378

Peptide-supported organometallic catalyst for dual transformations under ambient aqueous conditions.
Alexopoulos, Andrew D.

Peptide-supported organometallic catalyst for dual transformations under ambient aqueous conditions. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 60 p.

Source: Masters Abstracts International, Volume: 56-01.

Thesis (M.S.)--California State University, Long Beach, 2016.

As the benefits and importance of green chemistry become more apparent, interest in applying its philosophies across the entire spectrum of chemical industries has increased. At the heart of its appeal is the fact the green chemistry promotes processes that can be both environmentally friendly and economically efficient. The commercial benefits can be realized directly by increasing efficiency through the use of catalytic reagents or indirectly by reducing the costs of transporting, handling, and disposing of hazardous chemicals and solvents. Guided by the principles of green chemistry, we have immobilized palladium catalysts onto collagen mimetic peptides (CMPs) capable of performing dual, simultaneous transformations under ambient conditions in aqueous media. Due to their triple helical structure, the peptides form ridged-rod nanoparticles in aqueous solutions. This ridged structure allows for well-defined spatial control of two separate "active sites" by immobilizing palladium centers at specific residues. The first active site was achieved by substituting an arginine residue onto a generic CMP sequence. The second site was achieved by coupling a carboxylic acid-containing phosphine ligand to a lysine residue via amide bond formation. Both the gaunidinium group on the arginine side chain and the phosphine coupled to the lysine side chain, were capable of forming complexes with palladium precursors. These peptide-supported complexes were used as effective catalysts for Suzuki-Miyaura couplings and catalytic allylic substitution reactions in aqueous media under ambient conditions. Although the catalytic systems are still in the early stages of development, their fundamental design offers several advantages compared to traditional catalysts. For example, because the system provides control of spatial separation between catalytic sites, there is potential to promote synergistic effects between cooperative catalysts.

ISBN: 9781369025378Subjects--Topical Terms:

188628
Chemistry.

Peptide-supported organometallic catalyst for dual transformations under ambient aqueous conditions.
LDR:02874nmm a2200289 4500 001 502119
005 20170619070727.5
008 170818s2016 ||||||||||||||||| ||eng d
020 $a 9781369025378
035 $a (MiAaPQ)AAI10147312
035 $a AAI10147312
040 $a MiAaPQ $c MiAaPQ
100 1 $a Alexopoulos, Andrew D. $3 766142
245 1 0 $a Peptide-supported organometallic catalyst for dual transformations under ambient aqueous conditions.
260 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2016
300 $a 60 p.
500 $a Source: Masters Abstracts International, Volume: 56-01.
500 $a Adviser: Katarzyna Slowinska.
502 $a Thesis (M.S.)--California State University, Long Beach, 2016.
520 $a As the benefits and importance of green chemistry become more apparent, interest in applying its philosophies across the entire spectrum of chemical industries has increased. At the heart of its appeal is the fact the green chemistry promotes processes that can be both environmentally friendly and economically efficient. The commercial benefits can be realized directly by increasing efficiency through the use of catalytic reagents or indirectly by reducing the costs of transporting, handling, and disposing of hazardous chemicals and solvents. Guided by the principles of green chemistry, we have immobilized palladium catalysts onto collagen mimetic peptides (CMPs) capable of performing dual, simultaneous transformations under ambient conditions in aqueous media. Due to their triple helical structure, the peptides form ridged-rod nanoparticles in aqueous solutions. This ridged structure allows for well-defined spatial control of two separate "active sites" by immobilizing palladium centers at specific residues. The first active site was achieved by substituting an arginine residue onto a generic CMP sequence. The second site was achieved by coupling a carboxylic acid-containing phosphine ligand to a lysine residue via amide bond formation. Both the gaunidinium group on the arginine side chain and the phosphine coupled to the lysine side chain, were capable of forming complexes with palladium precursors. These peptide-supported complexes were used as effective catalysts for Suzuki-Miyaura couplings and catalytic allylic substitution reactions in aqueous media under ambient conditions. Although the catalytic systems are still in the early stages of development, their fundamental design offers several advantages compared to traditional catalysts. For example, because the system provides control of spatial separation between catalytic sites, there is potential to promote synergistic effects between cooperative catalysts.
590 $a School code: 6080.
650 4 $a Chemistry. $3 188628
650 4 $a Environmental science. $3 708819
690 $a 0485
690 $a 0768
710 2 $a California State University, Long Beach. $b Chemistry and Biochemistry. $3 730270
773 0 $t Masters Abstracts International $g 56-01(E).
790 $a 6080
791 $a M.S.
792 $a 2016
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10147312