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Novel optical endoscopes for early cancer diagnosis and therapy

Record Type:	Electronic resources : Monograph/item
Title/Author:	Novel optical endoscopes for early cancer diagnosis and therapyby Dale Jonathan Waterhouse.
Author:	Waterhouse, Dale Jonathan.
Published:	Cham :Springer International Publishing :2019.
Description:	xxi, 142 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Endoscopy.
Online resource:	https://doi.org/10.1007/978-3-030-21481-4
ISBN:	9783030214814$q(electronic bk.)

Novel optical endoscopes for early cancer diagnosis and therapy
Waterhouse, Dale Jonathan.

Novel optical endoscopes for early cancer diagnosis and therapy[electronic resource] /by Dale Jonathan Waterhouse. - Cham :Springer International Publishing :2019. - xxi, 142 p. :ill. (some col.), digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Translation of Optical Imaging Techniques -- Flexible Endoscopy: Early Detection of Dysplasia in Barrett's Oesophagus -- Flexible Endoscopy : Device Architecture -- Flexible Endoscopy: Optical Molecular Imaging -- Flexible Endoscopy: Multispectral Imaging -- Rigid Endoscopy for Intraoperative Imaging of Pituitary Adenoma -- Conclusions and Outlook -- Appendix.

This thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be exploited for biomedical applications, but relatively few have been translated into clinic. The work presented outlines for the first time, a comprehensive analysis of the common barriers and unique challenges associated with the translation of optical imaging techniques. To assist developers streamline translation of optical imaging devices in future, a roadmap to clinical translation is outlined, and key translational characteristics are defined. Guided by these, subsequent development of endoscopic devices resulted in preparation and approval of endoscopes for first in human trials in the oesophagus, for early detection of cancer, and in the brain, for delineation of tumour during surgical resection. The thesis culminates in the presentation of results from the first in human use of a compact multispectral endoscope for imaging endogenous tissue contrast in the oesophagus. With continuation of the work as outlined at the end of this thesis, the novel techniques described have the potential to improve the standard of care in their respective indications.

ISBN: 9783030214814$q(electronic bk.)

Standard No.: 10.1007/978-3-030-21481-4doiSubjects--Topical Terms:

281107
Endoscopy.

LC Class. No.: RC78.7.E5 / W384 2019

Dewey Class. No.: 616.07545

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520 $a This thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be exploited for biomedical applications, but relatively few have been translated into clinic. The work presented outlines for the first time, a comprehensive analysis of the common barriers and unique challenges associated with the translation of optical imaging techniques. To assist developers streamline translation of optical imaging devices in future, a roadmap to clinical translation is outlined, and key translational characteristics are defined. Guided by these, subsequent development of endoscopic devices resulted in preparation and approval of endoscopes for first in human trials in the oesophagus, for early detection of cancer, and in the brain, for delineation of tumour during surgical resection. The thesis culminates in the presentation of results from the first in human use of a compact multispectral endoscope for imaging endogenous tissue contrast in the oesophagus. With continuation of the work as outlined at the end of this thesis, the novel techniques described have the potential to improve the standard of care in their respective indications.
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