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Anaerobiosis and stemnessan evolutio...

Ivanovic, Zoran, (1963-)

Anaerobiosis and stemnessan evolutionary paradigm /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Anaerobiosis and stemnessZoran Ivanovic, Marija Vlaski-Lafarge.
Reminder of title:	an evolutionary paradigm /
Author:	Ivanovic, Zoran,
other author:	Vlaski-Lafarge, Marija,
Published:	Amsterdam :Elsevier,2016.
Description:	1 online resource.
Subject:	AnaerobiosisTherapeutic use.
Online resource:	https://www.sciencedirect.com/science/book/9780128005408
ISBN:	9780128006115 (electronic bk.)

Anaerobiosis and stemnessan evolutionary paradigm /
Ivanovic, Zoran,1963-

Anaerobiosis and stemnessan evolutionary paradigm /[electronic resource] :Zoran Ivanovic, Marija Vlaski-Lafarge. - Amsterdam :Elsevier,2016. - 1 online resource.

Includes bibliographical references and index.

Introduction : special remarks -- What entity could be called a stem cell? -- In situ Normoxia versus "hypoxia" -- Part 1. Anaerobiosis and stem cell entity. The "hypoxic" stem cell niche -- Low O2 concentrations and the maintenance of stem cells ex vivo -- Quiescence/proliferation issue and stem cell niche -- Metabolic peculiarities of the stem cell entity : energetic metabolism and oxidative status -- Molecular basis of "hypoxic" signaling, quiescence, self-renewal, and differentiation in stem cells -- Part 2. Anaerobic-to-aerobic eukaryote evolution : a paradigm for stem cell self-renewal, commitment and differentiation?. Evolution of eukaryotes with respect to atmosphere oxygen appearance and rise : anaerobiosis, facultative aerobiosis, and aerobiosis -- Evolution of mitochondria in eukaryotes versus mitochondria "maturing" from the stage of stem cells to committed progenitors and mature cells -- Evolutionary origins of stemness : relationship between self-renewal and ancestral eukaryote biology; conservation of self-renewal principle in parallel with adaptation to O2 -- Metabolic and genetic features of ancestral eukaryotes versus metabolism and "master pluripotency genes" of stem cells -- Other features concerning the analogy "stem cells: primitive eukaryotes" : ABC transporters' anaerobiosis/stemness link -- Harnessing anaerobic nature of stem cells for use in regenerative medicine -- Cancer stem cell case and evolutionary paradigm.

"Anaerobiosis and Stemness: An evolutionary paradigm provides a context for understanding the many complexities and evolutionary features of stem cells and the clinical implications of anaerobiosis stem cells. Combining theoretical and experimental knowledge, the authors provide a broad understanding of how the absence or low concentration of oxygen can play an influential role in the maintenance and self-renewal of stem cells and stem cell differentiation. This understanding has clinical implications for the fields of regenerative medicine, cancer biology and transplantation, as well as cell engineering and cell therapy. Anaerobiosis and Stemness is an important resource for stem cell and developmental biologists alike, as well as oncologists, cancer biologists, and researchers using stem cells for regeneration."--Page 4 of cover

ISBN: 9780128006115 (electronic bk.)Subjects--Topical Terms:

872071
Anaerobiosis
--Therapeutic use.Index Terms--Genre/Form:

214472
Electronic books.

LC Class. No.: QH518.5

Dewey Class. No.: 591.128

National Library of Medicine Call No.: QU 325

Anaerobiosis and stemnessan evolutionary paradigm /
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300 $a 1 online resource.
504 $a Includes bibliographical references and index.
505 0 $a Introduction : special remarks -- What entity could be called a stem cell? -- In situ Normoxia versus "hypoxia" -- Part 1. Anaerobiosis and stem cell entity. The "hypoxic" stem cell niche -- Low O2 concentrations and the maintenance of stem cells ex vivo -- Quiescence/proliferation issue and stem cell niche -- Metabolic peculiarities of the stem cell entity : energetic metabolism and oxidative status -- Molecular basis of "hypoxic" signaling, quiescence, self-renewal, and differentiation in stem cells -- Part 2. Anaerobic-to-aerobic eukaryote evolution : a paradigm for stem cell self-renewal, commitment and differentiation?. Evolution of eukaryotes with respect to atmosphere oxygen appearance and rise : anaerobiosis, facultative aerobiosis, and aerobiosis -- Evolution of mitochondria in eukaryotes versus mitochondria "maturing" from the stage of stem cells to committed progenitors and mature cells -- Evolutionary origins of stemness : relationship between self-renewal and ancestral eukaryote biology; conservation of self-renewal principle in parallel with adaptation to O2 -- Metabolic and genetic features of ancestral eukaryotes versus metabolism and "master pluripotency genes" of stem cells -- Other features concerning the analogy "stem cells: primitive eukaryotes" : ABC transporters' anaerobiosis/stemness link -- Harnessing anaerobic nature of stem cells for use in regenerative medicine -- Cancer stem cell case and evolutionary paradigm.
520 $a "Anaerobiosis and Stemness: An evolutionary paradigm provides a context for understanding the many complexities and evolutionary features of stem cells and the clinical implications of anaerobiosis stem cells. Combining theoretical and experimental knowledge, the authors provide a broad understanding of how the absence or low concentration of oxygen can play an influential role in the maintenance and self-renewal of stem cells and stem cell differentiation. This understanding has clinical implications for the fields of regenerative medicine, cancer biology and transplantation, as well as cell engineering and cell therapy. Anaerobiosis and Stemness is an important resource for stem cell and developmental biologists alike, as well as oncologists, cancer biologists, and researchers using stem cells for regeneration."--Page 4 of cover
588 0 $a Online resource; title from PDF title page (EBSCO, viewed December 9, 2015).
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650 2 2 $a Anaerobiosis. $3 344040
650 2 2 $a Cell Hypoxia. $3 872072
650 2 2 $a Cell Lineage. $3 872073
650 2 2 $a Cell Differentiation. $3 203925
650 2 2 $a Biological Evolution. $3 666378
655 4 $a Electronic books. $2 local. $3 214472
700 1 $a Vlaski-Lafarge, Marija, $e author. $3 872070
856 4 0 $u https://www.sciencedirect.com/science/book/9780128005408