國立高雄大學圖資館 |

Language: English

Back

Mechanisms of gene regulationhow sci...

Carlberg, Carsten.

Mechanisms of gene regulationhow science works /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Mechanisms of gene regulationby Carsten Carlberg, Ferdinand Molnar.
Reminder of title:	how science works /
Author:	Carlberg, Carsten.
other author:	Molnar, Ferdinand.
Published:	Cham :Springer International Publishing :2020.
Description:	xvi, 149 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
Subject:	Gene expression.
Online resource:	https://doi.org/10.1007/978-3-030-52321-3
ISBN:	9783030523213$q(electronic bk.)

Mechanisms of gene regulationhow science works /
Carlberg, Carsten.

Mechanisms of gene regulationhow science works /[electronic resource] :by Carsten Carlberg, Ferdinand Molnar. - Cham :Springer International Publishing :2020. - xvi, 149 p. :ill., digital ;24 cm.

Central dogma of molecular biology -- Impact of chromatin structure -- Epigenetics enables gene expression -- Gene regulation in the context of nuclear architecture -- Core promoter -- TATA box and other core promoter elements -- Genome-wide core promoter identification -- TFIID and Mediator as paradigms of multi-protein complexes -- Site-specific transcription factors and their domains -- Classification of transcription factors -- Activation of transcription factors -- Programing cellular differentiation by transcription factors -- Inflammatory signaling via NF-KB -- Sensing cellular stress via p53 -- The nuclear receptor superfamily -- Molecular interactions of nuclear receptors -- Physiological role of nuclear receptors -- Next-generation sequencing -- Gene regulation in the context of Big Biology -- Exploring genome-wide transcription factor binding -- Integrating epigenome-wide datasets -- Cytosines and their methylation -- Histone modifications -- Gene regulation via chromatin modifiers -- Sensing energy metabolism via chromatin modifiers -- Epigenetics and chromatin -- Genome-wide understanding of epigenetics -- CTCF and genetic imprinting -- Epigenetics in health and disease -- Nucleosome positioning at promoters -- Chromatin remodeling -- Transcriptional dynamics in the presence of chromatin -- Organization of the nucleus -- Non-coding RNAs -- miRNAs and their regulatory potential -- Long ncRNAs -- Enhancer RNAs.

This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.

ISBN: 9783030523213$q(electronic bk.)

Standard No.: 10.1007/978-3-030-52321-3doiSubjects--Topical Terms:

188888
Gene expression.

LC Class. No.: QH450 / .C37 2020

Dewey Class. No.: 572.865

Mechanisms of gene regulationhow science works /
LDR:03716nmm a2200325 a 4500 001 588704
003 DE-He213
005 20210122144336.0
006 m d
007 cr nn 008maaau
008 210525s2020 sz s 0 eng d
020 $a 9783030523213$q(electronic bk.)
020 $a 9783030523206$q(paper)
024 7 $a 10.1007/978-3-030-52321-3 $2 doi
035 $a 978-3-030-52321-3
040 $a GP $c GP
041 0 $a eng
050 4 $a QH450 $b .C37 2020
072 7 $a MBGR $2 bicssc
072 7 $a MED000000 $2 bisacsh
072 7 $a MBGR $2 thema
082 0 4 $a 572.865 $2 23
090 $a QH450 $b .C278 2020
100 1 $a Carlberg, Carsten. $3 677757
245 1 0 $a Mechanisms of gene regulation $h [electronic resource] : $b how science works / $c by Carsten Carlberg, Ferdinand Molnar.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2020.
300 $a xvi, 149 p. : $b ill., digital ; $c 24 cm.
505 0 $a Central dogma of molecular biology -- Impact of chromatin structure -- Epigenetics enables gene expression -- Gene regulation in the context of nuclear architecture -- Core promoter -- TATA box and other core promoter elements -- Genome-wide core promoter identification -- TFIID and Mediator as paradigms of multi-protein complexes -- Site-specific transcription factors and their domains -- Classification of transcription factors -- Activation of transcription factors -- Programing cellular differentiation by transcription factors -- Inflammatory signaling via NF-KB -- Sensing cellular stress via p53 -- The nuclear receptor superfamily -- Molecular interactions of nuclear receptors -- Physiological role of nuclear receptors -- Next-generation sequencing -- Gene regulation in the context of Big Biology -- Exploring genome-wide transcription factor binding -- Integrating epigenome-wide datasets -- Cytosines and their methylation -- Histone modifications -- Gene regulation via chromatin modifiers -- Sensing energy metabolism via chromatin modifiers -- Epigenetics and chromatin -- Genome-wide understanding of epigenetics -- CTCF and genetic imprinting -- Epigenetics in health and disease -- Nucleosome positioning at promoters -- Chromatin remodeling -- Transcriptional dynamics in the presence of chromatin -- Organization of the nucleus -- Non-coding RNAs -- miRNAs and their regulatory potential -- Long ncRNAs -- Enhancer RNAs.
520 $a This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.
650 0 $a Gene expression. $3 188888
650 1 4 $a Biomedicine, general. $3 853300
650 2 4 $a Biochemistry, general. $3 273649
650 2 4 $a Genetics and Genomics. $3 827523
700 1 $a Molnar, Ferdinand. $3 677758
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer Nature eBook
856 4 0 $u https://doi.org/10.1007/978-3-030-52321-3
950 $a Biomedical and Life Sciences (SpringerNature-11642)