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Histone mutations and cancer

Fang, Dong.

Histone mutations and cancer

Record Type:	Electronic resources : Monograph/item
Title/Author:	Histone mutations and canceredited by Dong Fang, Junhong Han.
other author:	Fang, Dong.
Published:	Singapore :Springer Singapore :2021.
Description:	vii, 96 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer Nature eBook
Subject:	Mutation (Biology)
Online resource:	https://doi.org/10.1007/978-981-15-8104-5
ISBN:	9789811581045$q(electronic bk.)

Histone mutations and cancer
Histone mutations and cancer[electronic resource] /edited by Dong Fang, Junhong Han. - Singapore :Springer Singapore :2021. - vii, 96 p. :ill. (some col.), digital ;24 cm. - Advances in experimental medicine and biology,v.12830065-2598 ;. - Advances in experimental medicine and biology ;946..

Chapter 1: Overview of histone modification -- Chapter 2: The histone H3 family and its deposition pathways -- Chapter 3: Histone H3K27M Mutation in Brain Tumors -- Chapter 4: Histone Mutations and Bone Cancers -- Chapter 5: Histone H3G34 mutation in brain and bone tumors -- Chapter 6: Epigenetic-targeted treatments for H3K27M-mutant midline gliomas -- Chapter 7: Histone lysine to methionine mutation as anti-cancer drug target.

This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones. This book highlights the advances made in the area over the past 10 years, and offers a state-of-the-art summary of epigenetic alternation, gene expression, protein structure, drug discovery, immunotherapy, and mouse modeling of histone H3 mutations in various tumors. Chiefly intended to provide researchers and graduate students with an overall picture of these mutations, it will also be of interest to researchers in basic oncology, clinical oncology, and epigenetics, as well as academics and clinical oncology practitioners.

ISBN: 9789811581045$q(electronic bk.)

Standard No.: 10.1007/978-981-15-8104-5doiSubjects--Topical Terms:

277927
Mutation (Biology)

LC Class. No.: QP552.H5 / H57 2021

Dewey Class. No.: 572.66

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505 0 $a Chapter 1: Overview of histone modification -- Chapter 2: The histone H3 family and its deposition pathways -- Chapter 3: Histone H3K27M Mutation in Brain Tumors -- Chapter 4: Histone Mutations and Bone Cancers -- Chapter 5: Histone H3G34 mutation in brain and bone tumors -- Chapter 6: Epigenetic-targeted treatments for H3K27M-mutant midline gliomas -- Chapter 7: Histone lysine to methionine mutation as anti-cancer drug target.
520 $a This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones. This book highlights the advances made in the area over the past 10 years, and offers a state-of-the-art summary of epigenetic alternation, gene expression, protein structure, drug discovery, immunotherapy, and mouse modeling of histone H3 mutations in various tumors. Chiefly intended to provide researchers and graduate students with an overall picture of these mutations, it will also be of interest to researchers in basic oncology, clinical oncology, and epigenetics, as well as academics and clinical oncology practitioners.
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