國立高雄大學圖資館 |

登入

回首頁

Discovery of small-molecule modulators of protein-RNA interactions for treating cancer and COVID-19

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Discovery of small-molecule modulators of protein-RNA interactions for treating cancer and COVID-19by Wan Gi Byun.
作者:	Byun, Wan Gi.
出版者:	Singapore :Springer Nature Singapore :2023.
面頁冊數:	xxxii, 128 p. :ill., digital ;24 cm.
附註:	"Doctoral thesis accepted by Seoul National University, Seoul, Korea (Republic of)"
Contained By:	Springer Nature eBook
標題:	RNA-protein interactions.
電子資源:	https://doi.org/10.1007/978-981-19-7814-2
ISBN:	9789811978142$q(electronic bk.)

Discovery of small-molecule modulators of protein-RNA interactions for treating cancer and COVID-19
Byun, Wan Gi.

Discovery of small-molecule modulators of protein-RNA interactions for treating cancer and COVID-19[electronic resource] /by Wan Gi Byun. - Singapore :Springer Nature Singapore :2023. - xxxii, 128 p. :ill., digital ;24 cm. - Springer theses,2190-5061. - Springer theses..

"Doctoral thesis accepted by Seoul National University, Seoul, Korea (Republic of)"

1. Introduction -- 2. Identification of Small-Molecule Inhibitors of Oncogenic Lin28-Let-7 Interaction -- 3. Discovery of Small-Molecule Modulators of Protein-RNA Interactions by Fluorescence Intensity-Based Binding Assay -- 4. Harnessing Stress Granule Formation by Small Molecules to Inhibit the Cellular Replication of SARS-CoV-2 -- Appendix.

This book describes the development of novel protein-RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein-RNA interactions to treat cancer and COVID-19. Modulating protein-RNA interactions with small molecules is expected to provide novel biological insights of the interrelation of diseases with the protein-RNA interactome. The modulations may also be exploited therapeutically. For these reasons, the development of a simple, reliable, and sensitive protein-RNA-binding assay is necessary for high-throughput screening to discover new effective chemical entities capable of acting on diverse protein-RNA interactions. This book discusses the discovery of small-molecule modulators targeting protein-RNA interactions that are potentially valuable to treat cancer and COVID-19 by constructing novel high-throughput screening methods. The results of this dissertation provide valuable insights into the regulation of protein-RNA interactions in chemical biology and drug development.

ISBN: 9789811978142$q(electronic bk.)

Standard No.: 10.1007/978-981-19-7814-2doiSubjects--Topical Terms:

202875
RNA-protein interactions.

LC Class. No.: QP623.8.P75 / B98 2023

Dewey Class. No.: 572.633

Discovery of small-molecule modulators of protein-RNA interactions for treating cancer and COVID-19
LDR:02572nmm a2200349 a 4500 001 645233
003 DE-He213
005 20221213201814.0
006 m d
007 cr nn 008mamaa
008 231208s2023 si s 0 eng d
020 $a 9789811978142$q(electronic bk.)
020 $a 9789811978135$q(paper)
024 7 $a 10.1007/978-981-19-7814-2 $2 doi
035 $a 978-981-19-7814-2
040 $a GP $c GP
041 0 $a eng
050 4 $a QP623.8.P75 $b B98 2023
072 7 $a T $2 bicssc
072 7 $a SCI009000 $2 bisacsh
072 7 $a T $2 thema
082 0 4 $a 572.633 $2 23
090 $a QP623.8.P75 $b B998 2023
100 1 $a Byun, Wan Gi. $3 953967
245 1 0 $a Discovery of small-molecule modulators of protein-RNA interactions for treating cancer and COVID-19 $h [electronic resource] / $c by Wan Gi Byun.
260 $a Singapore : $b Springer Nature Singapore : $b Imprint: Springer, $c 2023.
300 $a xxxii, 128 p. : $b ill., digital ; $c 24 cm.
490 1 $a Springer theses, $x 2190-5061
500 $a "Doctoral thesis accepted by Seoul National University, Seoul, Korea (Republic of)"
505 0 $a 1. Introduction -- 2. Identification of Small-Molecule Inhibitors of Oncogenic Lin28-Let-7 Interaction -- 3. Discovery of Small-Molecule Modulators of Protein-RNA Interactions by Fluorescence Intensity-Based Binding Assay -- 4. Harnessing Stress Granule Formation by Small Molecules to Inhibit the Cellular Replication of SARS-CoV-2 -- Appendix.
520 $a This book describes the development of novel protein-RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein-RNA interactions to treat cancer and COVID-19. Modulating protein-RNA interactions with small molecules is expected to provide novel biological insights of the interrelation of diseases with the protein-RNA interactome. The modulations may also be exploited therapeutically. For these reasons, the development of a simple, reliable, and sensitive protein-RNA-binding assay is necessary for high-throughput screening to discover new effective chemical entities capable of acting on diverse protein-RNA interactions. This book discusses the discovery of small-molecule modulators targeting protein-RNA interactions that are potentially valuable to treat cancer and COVID-19 by constructing novel high-throughput screening methods. The results of this dissertation provide valuable insights into the regulation of protein-RNA interactions in chemical biology and drug development.
650 0 $a RNA-protein interactions. $3 202875
650 0 $a Cancer $x Genetic aspects. $3 189391
650 0 $a Cancer $x Molecular aspects. $3 221221
650 0 $a COVID-19 (Disease) $x Genetic aspects. $3 953968
650 0 $a COVID-19 (Disease) $x Molecular aspects. $3 894565
650 1 4 $a Biological and Physical Engineering. $3 953722
650 2 4 $a Chemical Bioengineering. $3 918702
650 2 4 $a Biophysics. $3 188608
650 2 4 $a Protein Folding. $3 303195
650 2 4 $a RNA Interference. $3 230168
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer Nature eBook
830 0 $a Springer theses. $3 557607
856 4 0 $u https://doi.org/10.1007/978-981-19-7814-2
950 $a Engineering (SpringerNature-11647)