Chemistry, Biochemistry.
Overview
| Works: | 146 works in 0 publications in 0 languages | |
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Titles
Do you speak genomics? Patenting biotechnology "Translation" inventions and other macromolecules.
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The synthesis and biologic evaluation of exhaustively stereodiversified libraries of acyclic 1,5-enediols.
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Glycosyltransferases involved in the biosynthesis of glycopeptide antibiotics.
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Processivity of the herpes simplex virus DNA polymerase :Role of high-affinity DNA binding by the processivity subunit.
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Chemical genetics applied to the search for kinase protein substrates :A new class of triphosphate analogs.
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Electron transfer and folding studies in designed three-helix bundle peptides :The effects of main chain hydrogen bonds.
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Selection and analysis of RNA-cleaving deoxyribozymes and ribozymes :Application toward understanding enzyme structure and function.
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An amino-terminal region of Caenorhabditis elegans RGS proteins EGL-10 and EAT-16 directs inhibition of heterotrimeric G protein signaling.
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UsingcDNA phage display for the direct cloning of cellular proteins and functional identification of natural product receptors.
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Dissection of conformational changes in the tetrahymena group I ribozyme and self-splicing reactions.
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Interactions of non-heme ferrous active sites with substrates :Structure/function correlations for phenylalanine hydroxylase and bleomycin.
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Single cell analysis of multiple intracellular processes :ICAM-2/LFA-1 interactions as functional adhesion molecules of the immunological synapse.
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Study of the dynamin PH domain and its role in receptor-mediated endocytosis.
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Monosaccharide-based beta turn mimetics for the somatostatin and neurokinin-1 receptors.
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Control of megakaryocyte-specific gene regulation :GATA-1, FOG-1, Fli-1 cooperativity in alpha IIB gene expression.
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The role of ER quality control and protein misfolding in retinal degeneration caused by a mutation in rhodopsin.
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Structural and biochemical studies on human 8-oxoguanine DNA glycosylase, and transcriptional profiling of the Escherichia coli adaptive response to alkylation.
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Biosynthesis of the Pseudomonas aeruginosa siderophore pyochelin :Peptide synthesis and tailoring.
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Coordination of mammalian base excision repair of DNA by AP endonuclease 1 and DNA polymerase beta.
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Signaling pathways of microbial product receptors Toll-like receptors and CD14.
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Structural insights into the mechanism and inhibition of prostaglandin H2 synthase-1.
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Caspase regulation :Mechanism of the activation and inhibition of caspase-9.
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Structural and functional studies of well-folded alpha helical proteins from a designed combinatorial library.
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Networks of protein interactions at the nuclear pore complex in Saccharomyces cerevisiae.
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Regulation of sporulation-specific transcription factors by proteolysis in Bacillus subtilis.
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Covalent modifications of Salmonella lipid A :Roles of macrophages, media, and a membrane-bound hydroxylase.
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IRS-1 inhibition of SERCA :A potential molecular interaction mechanism for regulation of insulin secretion and calcium homeostasis in pancreatic beta-cells.
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Identifying conformationally labile functional regions of Escherichia coli ribosomes using chemical probes.
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Studies on the molecular basis of substrate specificity and inhibition of the GCN5/PCAF histone acetyltransferases.
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The mechanism of insulin action on islet amyloid polypeptide fiber formation.
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Nucleotide analog interference mapping of the Neurospora Varkud satellite ribozyme :Implications for the catalytic mechanism.
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Dramatic structural and thermodynamic consequences of repacking a protein's hydrophobic core.
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Contributions of voltage-gated sodium, calcium and potassium currents to the excitability of nociceptive sensory neurons
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Coordinate defense responses in three-way interactions between plants, insects and pathogens :Arabidopsis thaliana, Trichoplusia ni, and Pseudomonas syringae
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The role of surfactant proteins A and D in innate immunity :Regulation of inflammation and bacterial abrogation of protein function
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Biophysical and computational investigations of protein-protein interactions in mitochondria-dependent apoptosis
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Mechanistic and structure-function analysis of thymidylate synthase-dihydrofolate reductase from protozoal parasites :Implications for the development of non-active site inhibitors
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Active roles of Gpa1, Scp160, and Apg14 in the yeast pheromone response pathway
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X-ray crystallographic refinement and analysis of the Haloarcula marismortui large ribosomal subunit
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A single amidotransferase forms amide aminoacyl-tRNAs in Chlamydia trachomatis
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Solution structure of ribosomal protein L18 from Bacillus stearothermophilus
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Global solution structure of IHF-induced DNA bend using cyclization kinetics and Monte Carlo simulation
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Studies of membrane and membrane protein systems using molecular dynamics simulations.
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Genetic and genomic studies of FGF signaling and development in Drosophila melanogaster
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Dissecting the mechanism of processive motility in single myosin V molecules
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The design, synthesis and evaluation of guanidine-based molecular transporters.
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Investigation of the microenvironments of nonionic Tween 85 reverse micelle systems and mixed Tween 85 reverse micelle systems and their utilization as reaction media for enyzme catalysis
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Structure function studies on the dimethyl sulfoxide reductase family of molybdopterin enyzmes
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Thermodynamic analysis of protein folding reactions by H/D exchange and matrix assisted laser desorption/ionization time of flight mass spectrometry
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Total chemical synthesis and biophysical characterization of backbone-modified protein analogues
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The development of DNA-templated organic synthesis :Mimicking nature's effective molarity-based approach to controlling chemical reactivity
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Alpha-synuclein sequence variants :Secondary structure formation and aggregation
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Macrocyclization catalysis by excised thioesterase domains from natural product synthetases
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Structural and chemical genetic insights into protein-protein interactions of phosphate-dependent cell signaling :The cases of calcineurin and protein kinase C iota.
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Diversity-generating mechanisms of non-ribosomal peptide synthetases :I. Enzymes in the biosynthesis of 3,5-dihydroxy-L-phenylglycine. II. Thioesterase domain of the surfactin synthetase
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Discovery of small molecule probes for chemical genetics using biased and unbiased diversity-oriented organic synthesis.
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Ribosomal S6 kinase (RSK) phosphorylates filamin A on an important regulatory site :Implications for RSK in the control of cell migration
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I. X-ray crystal structure of the MurG:UDP-GlcNAc cocomplex. II. High throughput screening of Escherichia coli MurG.
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From G proteins to mitosis: Identifying new roles of the beta-catenin oncoprotein.
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Biochemistry of endotoxin in Rhizobium leguminosarum: Characterization of a family of lipid phosphatases specific for the 1-position of lipid A.
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Coupled interaction of hMutSalpha nucleotide and DNA mismatch binding activities.
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Inhibition of isoprenylcysteine carboxyl methyltransferase: A new (old) target in oncogenesis.
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Design, characterization of amphiphilic proteins and potential engineering applications.
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Understanding transglycosylase inhibition: Chlorobiphenyl vancomycin and moenomycin A as targets for synthesis and modification.
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Lipid II, transglycosylases, and clinically relevant bacterial strains: Tools for understanding glycopeptide antibiotic mode of action.
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Design of functional proteins for molecular recognition: Engineering of a coiled coil metalloprotein.
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The dual role of FG nucleoporins in nuclear import and formation of the permeability barrier at nuclear pore complexes.
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De novo folding networks and the substrate spectrum of the eukaryotic chaperonin TRiC/CCT.
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Electrochemical and functional studies of de novo alpha helical proteins from a designed combinatorial library.
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Investigations of Escherichia coli alkaline phosphatase and phosphoryl transfer via comparative analysis.
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Engineering and analysis of luciferases as quantitative reporter genes in live mammalian cells.
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Two different aspects of cell metabolism: (i) Recovery from growth inhibition in vivo, and (ii) the biochemical consequences of a split gene.
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Molecular recognition of protein surfaces by rational and combinatorial methods.
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The role of the Abl-related gene (Arg) tyrosine kinase in the regulation of adhesion-dependent cellular morphogenesis.
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Functional and biochemical characterization of the negative regulatory region of mammalian Notch.
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Evolutionary principles applied to the discovery of small molecules, homing endonucleases, and eukaryotic promoter elements.
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Expanding the toolbox for making polyketides in Escherichia coli: Heterologous expression of ansamycin polyketides and engineered synthesis of 2-substituted malonyl-CoAs.
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Mechanistic studies of enzymatic C-H bond hydroxylation by radical clocks.
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Sequence determinants and inhibition of the aggregation of the Alzheimer's Abeta peptide.
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Structural and biochemical studies of bacterial nucleotide excision repair enzymes: UvrA and UvrC.
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Development of new approaches to NMR data collection for protein structure determination.
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Characterization of beta-arrestin-modulated lipid kinase activities for diacylglycerol and phosphatidylinositol 4-phosphate.
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Proteolysis of immobilized proteins at the solid/aqueous interface: Implications for detergency.
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Characterization and engineering of a thermophilic chaperone to improve enzyme stability in denaturing co-solvents.
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X-ray absorption and infrared spectra of water and ice: A first-principles electronic structure study.
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Physiological control of photosynthesis and fermentation in the cyanobacterium Arthrospira (Spirulina) maxima CS-328 for biofuel production.
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Isolation and analysis of peptides binding to helix 69 of E. coli 23 S rRNA from M13 phage display.
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The use of mass spectrometry to characterize the metabolic output of bacterial pathogens.
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Promotion of antibody orientation by unique noncovalent polymer-protein pairing: Structural elucidation, mechanistic analysis, and applications in immunoassays and biosensors.
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Biochemical and Biophysical Characterization of Five Key Mutations in the ABC Transporter MsbA.
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Isolation, Characterization, and Bioinformatics Analysis of Bovine Brain Membrane Proteins.
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Structural and bioinformatic studies of the short chain oxidoreductase enzyme family.
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Probing DNA-induced colloidal interactions and dynamics with scanning-line optical tweezers.
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Advances in analysis of novel protein therapeutics and clinical samples with LC-MS/MS methods.
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